Moderate deterioration in glucose tolerance during high-dose growth hormone therapy in glucocorticoid-treated patients with juvenile idiopathic arthritis

Hormone Research in Paediatrics

Volumn 73, Issue 6, 2010, Pages 465-472

  Bismuth, Elise ^a   Chevenne, Didier ^a   Czernichow, Paul ^a   Simon, Dominique ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

Diabetes; Glucocorticoid therapy; Growth hormone treatment; Insulin resistance; Juvenile idiopathic arthritis

Indexed keywords

GLUCOCORTICOID; HEMOGLOBIN A1C; INSULIN; SOMATREM;

ADOLESCENT; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DIABETES MELLITUS; DRUG MEGADOSE; EARLY INTERVENTION; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; HORMONAL THERAPY; HUMAN; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN SENSITIVITY; INSULINEMIA; JUVENILE RHEUMATOID ARTHRITIS; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; OBESITY; OBSERVATIONAL STUDY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SIDE EFFECT;

ADOLESCENT; AREA UNDER CURVE; ARTHRITIS, JUVENILE RHEUMATOID; BLOOD GLUCOSE; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; FEMALE; GLUCOCORTICOIDS; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HEMOGLOBIN A, GLYCOSYLATED; HUMAN GROWTH HORMONE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; REGRESSION ANALYSIS;

EID: 77952298303     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000313589     Document Type: Article

References (25)

1. Simon D, Fernando C, Czernichow P, Prieur AM: Linear growth and final height in patients with systemic juvenile idiopathic arthritis treated with long-term glucocorticoids. J Rheumatol 2002; 29: 1296-1300.
2. Simon D, Lucidarme N, Prieur AM, Ruiz JC, Czernichow P: Effects on growth and body composition of growth hormone treatment in children with juvenile idiopathic arthritis requiring steroid therapy. J Rheumatol 2003; 30: 2492-2499.
3. Bechtold S, Ripperger P, Dalla Pozza R, Bonfig W, Hafner R, Michels H, Schwarz HP: Growth hormone increases final height in patients with juvenile idiopathic arthritis: data from a randomized controlled study. J Clin Endocrinol Metab 2007; 92: 3013-3018.
4. Simon D, Prieur AM, Quartier P, Charles Ruiz J, Czernichow P: Early recombinant human growth hormone treatment in glucocorticoid- treated children with juvenile idiopathic arthritis: a 3-year randomized study. J Clin Endocrinol Metab 2007; 92: 2567-2573.
5. Cutfield WS, Wilton P, Bennmarker H, Albertsson-Wikland K, Chatelain P, Ranke MB, Price DA: Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment. Lancet 2000; 355: 610-613.
6. Pittas AG, Joseph NA, Greenberg AS: Adipocytokines and insulin resistance. J Clin Endocrinol Metab 2004; 89: 447-452.
7. Horber FF, Marsh HM, Haymond MW: Differential effects of prednisone and growth hormone on fuel metabolism and insulin antagonism in humans. Diabetes 1991; 40: 141-149.
8. Allen DB, Julius JR, Breen TJ, Attie KM: Treatment of glucocorticoid-induced growth suppression with growth hormone: national cooperative growth study. J Clin Endocrinol Metab 1998; 83: 2824-2829.
9. Mauras N, George D, Evans J, Milov D, Abrams S, Rini A, Welch S, Haymond MW: Growth hormone has anabolic effects in glucocorticosteroid- dependent children with inflammatory bowel disease: a pilot study. Metabolism 2002; 51: 127-135.
10. Sempe M PG, Pernot MP: Auxologie: methodes et sequences. Paris, Theraplix, 1979.
11. Rolland-Cachera MF, Cole TJ, Sempe M, Tichet J, Rossignol C, Charraud A: Body mass index variations: centiles from birth to 87 years. Eur J Clin Nutr 1991; 45: 13-21.
12. Tanner JM, Whitehouse RH: Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 1976; 51: 170-179.
13. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH: Establishing a standard definition for child overweight and obesity worldwide: International survey. BMJ 2000; 320: 1240-1243.
14. American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes Care 2006; 29(suppl 1):S43-S48.
15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
16. Gungor N, Saad R, Janosky J, Arslanian S: Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents. J Pediatr 2004; 144: 47-55.
17. Tresaco B, Bueno G, Pineda I, Moreno LA, Garagorri JM, Bueno M: Homeostatic model assessment (HOMA) index cut-off values to identify the metabolic syndrome in children. J Physiol Biochem 2005; 61: 381-388.
18. de Benedetti F, Massa M, Robbioni P, Ra - velli A, Burgio GR, Martini A: Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis. Arthritis Rheum 1991; 34: 1158-1163.
19. Rizza RA, Mandarino LJ, Gerich JE: Cortisol- induced insulin resistance in man: Impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action. J Clin Endocrinol Metab 1982; 54: 131-138.
20. Hannon TS, Janosky J, Arslanian SA: Longitudinal study of physiologic insulin resistance and metabolic changes of puberty. Pediatr Res 2006; 60: 759-763.
21. Moran A, Jacobs DR Jr, Steinberger J, Hong CP, Prineas R, Luepker R, Sinaiko AR: Insulin resistance during puberty: results from clamp studies in 357 children. Diabetes 1999; 48: 2039-2044.
22. Travers SH, Jeffers BW, Bloch CA, Hill JO, Eckel RH: Gender and tanner stage differences in body composition and insulin sensitivity in early pubertal children. J Clin Endocrinol Metab 1995; 80: 172-178.
23. Bratusch-Marrain PR, Smith D, DeFronzo RA: The effect of growth hormone on glucose metabolism and insulin secretion in man. J Clin Endocrinol Metab 1982; 55: 973-982. (Pubitemid 13054363)
24. Rizza RA, Mandarino LJ, Gerich JE: Effects of growth hormone on insulin action in man: mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization. Diabetes 1982; 31: 663-669.
25. Bechtold S, Ripperger P, Bonfig W, Pozza RD, Haefner R, Schwarz HP: Growth hormone changes bone geometry and body composition in patients with juvenile idiopathic arthritis requiring glucocorticoid treatment: a controlled study using peripheral quantitative computed tomography. J Clin Endocrinol Metab 2005; 90: 3168-3173.