Infectious intracranial complications in the neuro-ICU patient population

Current Opinion in Critical Care

Volumn 16, Issue 2, 2010, Pages 117-122

  Beer, Ronny ^a   Pfausler, Bettina ^a   Schmutzhard, Erich ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Antibiotics; Intracranial infection; Neuro ICU patient; Nosocomial meningitis

Indexed keywords

ANTIINFECTIVE AGENT; CEFEPIME; CEFOTAXIME; CEPHALOSPORIN; LINEZOLID; MEROPENEM; METRONIDAZOLE; MOXIFLOXACIN; POLYMYXIN; VANCOMYCIN;

ANASTOMOSIS; BRAIN INFECTION; CATHETER; CENTRAL NERVOUS SYSTEM INFECTION; CLINICAL FEATURE; CONTAMINATION; DIAGNOSTIC PROCEDURE; DRUG EFFICACY; HOSPITAL INFECTION; HUMAN; INJURY; INTENSIVE CARE; INTENSIVE CARE UNIT; INVASIVE PROCEDURE; LENGTH OF STAY; MICROBIOLOGY; MORBIDITY; MORTALITY; NEUROIMAGING; NONHUMAN; PATHOGENESIS; PHARMACODYNAMICS; PREVALENCE; REVIEW;

ANTI-BACTERIAL AGENTS; CENTRAL NERVOUS SYSTEM INFECTIONS; CRITICAL CARE; CROSS INFECTION; HUMANS; INTENSIVE CARE UNITS; MENINGITIS, BACTERIAL; RISK FACTORS; TIME FACTORS;

EID: 77952290919     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/MCC.0b013e328338cb5f     Document Type: Review

References (45)

1. Beer R, Lackner P, Pfausler B, et al. Nosocomial ventriculitis and meningitis in neurocritical care patients. J Neurol 2008;255:1617-1624.
2. Ziai WC, Lewin JJ. Advances in the management of central nervous system infections in the ICU. Crit Care Clin 2006;22:661-694. (Pubitemid 46110958)
3. Lujan M, Gallego M, Rello J. Healthcare-associated infections. A useful concept? Curr Opin Crit Care 2009;15:419-424.
4. Frontera JA, Fernandez A, Schmidt JM, et al. Impact of nosocomial infectious complications after subarachnoid hemorrhage. Neurosurgery 2008;62:80-87. (Pubitemid 351640262)
5. Raad I, Hanna H, Maki D. Intravascular catheter-related infections: advances in diagnosis, prevention, and management. Lancet Infect Dis 2007;7:645-657. (Pubitemid 47444563)
6. Pytel P, Alexander JJ. Pathogenesis of septic encephalopathy. Curr Opin Neurol 2009;22:283-287.
7. Siami S, Annane D, Sharshar T, et al. The encephalopathy in sepsis. Crit Care Clin 2008;24:67-82. This review gives an overview on the pathophysiology of this severe neurological complication of sepsis. (Pubitemid 351187772)
8. Hermans G, De Jonghe B, Bruyninckx F, et al. Clinical review: critical illness polyneuropathy and myopathy. Crit Care 2008;12:238.
9. Zolldann D, Spitzer C, Hafner H, et al. Surveillance of nosocomial infections in a neurologic intensive care unit. Infect Control Hosp Epidemiol 2005;26:726-731. (Pubitemid 41169744)
10. Schade RP, Sinkel J, Visser LG, et al. Bacterial meningitis caused by the use of ventricular or lumbar cerebrospinal fluid catheters. J Neurosurg 2005;102:229-234.
11. Weisfelt M, vande Beek D, Spanjaard L, et al. Nosocomial bacterial meningitis in adults: a prospective series of 50 cases. J Hosp Infect 2007;66:71-78. (Pubitemid 46657135)
12. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of healthcare-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008;36:309-332. This document published by the National Healthcare Safety Network, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, gives an update on the definition of the specific types of healthcare-associated infections with special emphasis on surveillance purposes for use in public reporting. (Pubitemid 351763841)
13. Broessner G, Helbok R, Lackner P, et al. Survival and long-term functional outcome in 1, 155 consecutive neurocritical care patients. Crit Care Med 2007;35:2208-2209. (Pubitemid 47326437)
14. Lozier AP, Sciacca RR, Romagnoli MF, et al. Ventriculostomy-related infections: a critical review of the literature. Neurosurgery 2002;51:170-181.
15. Hoefnagl D, Dammers R, Ter Laak-Poort MP, et al. Risk factors for infections related to external ventricular drainage. Acta Neurochir 2008;150:209-214.
16. Zarrouk V, Vassor I, Bert F, et al. Evaluation of the management of postoperative aseptic meningitis. Clin Infect Dis 2007;44:1555-1559. (Pubitemid 46871501)
17. Conen A, Walti LN, Merlo A, et al. Characteristics and treatment outcome of cerebrospinal fluid shunt-associated infections in adults: a retrospective analysis over an 11-year period. Clin Infect Dis 2008;47:73-82. This is a retrospective analysis of consecutive episodes of cerebrospinal fluid shunt-associated infections in adults describing the epidemiological, clinical, laboratory, and microbiological characteristics and treatment outcome. (Pubitemid 351920591)
18. Korinek AM, Baugnon T, Golmard JL, et al. Risk factors for adult nosocomial meningitis after craniotomy: role of antibiotic prophylaxis. Neurosurgy 2006;59:126-133. (Pubitemid 44024364)
19. McClelland S 3rd, Hall WA. Postoperative central nervous system infection: incidence and associated factors in 2, 111 neurosurgical procedures. Clin Infect Dis 2007;45:55-59. (Pubitemid 46984616)
20. Baltas I, Tsoulfa S, Sakellariou P, et al. Posttraumatic meningitis: bacteriology, hydrocephalus, and outcome. Neurosurgery 1994;35:422-426.
21. van Zanten AR, Dixon JM, Nipshagen MD, et al. Hospital-acquired sinusitis is a common cause of fever of unknown origin in orotracheally intubated critically ill patients. Crit Care 2005;9:583-590.
22. Lackner P, Beer R, Broessner G, et al. Efficacy of silver nanoparticlesimpregnated external ventricular drain catheters in patients with acute occlusive hydrocephalus. Neurocrit Care 2008;8:360-365.
23. Lo CH, Spelman D, Bailey M, et al. External ventricular drain infections are independent of drain duration: an argument against elective revision. J Neurosurg 2002;106:378-383. (Pubitemid 46354289)
24. Korinek AM, Golmard JL, Eicheick A, et al. Risk factors for neurosurgical site infections after craniotomy: a critical reappraisal of antibiotic prophylaxis on 4, 578 patients. Br J Neurosurg 2005;19:155-162.
25. Dettenkofer M, Ebner W, Eis T, et al. Surveillance of nosocomial infections in a neurology intensive care unit. J Neurol 2001;248:959-964. (Pubitemid 36124721)
26. Schade RP, Schinkel J, Roelandse FW, et al. Lack of value of routine analysis of cerebrospinal fluid for prediction and diagnosis of external drainage-related bacterial meningitis. J Neurosurg 2006;104:101-108. (Pubitemid 43304351)
27. Diringer MN, Reaven NL, Funk SE, et al. Elevated body temperature independently contributes to increased length of stay in neurologic intensive care unit patients. Crit Care Med 2004;32:1489-1495.
28. Kilpatrick MM, Lowry DW, Firlik AD, et al. Hyperthermia in the neurosurgical intensive care unit. Neurosurgery 2000;47:850-855.
29. Martinez R, Gaul C, Buchfelder M, et al. Serum procalcitonin monitoring for differential diagnosis of ventriculitis in adult intensive care patients. Intensive Care Med 2002;28:208-210. (Pubitemid 34293835)
30. Muttaiyah S, Ritchie S, Upton A, Roberts S. clinical parameters do not predict infection in patients with external ventricular drains: a retrospective observational study of daily cerebrospinal fluid analysis. J Med Microbiol 2008;57:207-209. This study addresses the clinical impact of routine daily cerebrospinal fluid sampling and analysis in predicting external ventricular drain-associated ventriculitis. (Pubitemid 351231405)
31. Pfausler B, Beer R, Engelhardt K, et al. Cell index: a new parameter for the early diagnosis of ventriculostomy (external ventricular drainage) -related ventriculitis in patients with intraventricular hemorrhage? Acta Neurochir 2004;146:477-481. (Pubitemid 38649430)
32. Beer R, Pfausler B, Schmutzhard E. Management of nosocomial external ventricular drain-related ventriculomeningitis. Neurocrit Care 2009;10:363-367.
33. Iregui M, Ward S, Sherman G, et al. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 2002;122:262-268. (Pubitemid 34754172)
34. Proulx N, Fréchette D, Toye B, et al. Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis. QJM 2005;98:291-298. (Pubitemid 40500689)
35. Weisfelt M, de Gans J, van de Beek D. Bacterial meningitis: a review of effective pharmacotherapy. Expert Opin Pharmacother 2007;8:1493-1504. (Pubitemid 47082699)
36. Pfausler B, Spiss H, Beer R, et al. Treatment of staphylococcal ventriculitis associated with external cerebrospinal fluid drains: a prospective randomized trial of intravenous compared with intraventricular vancomycin therapy. J Neurosurg 2003;98:1040-1044. (Pubitemid 36460895)
37. Ziai WC, Lewin JJ. Improving the role of intraventricular antimicrobial agents in the management of meningitis. Curr Opin Neurol 2009;22:277-282. This recent review discusses indications for intraventricular antibiotics, choice of antimicrobial agents from the standpoint of pharmacodynamics and pharmacokinetics for bacterial and fungal meningitis.
38. Beer R, Engelhardt KW, Pfausler B, et al. Pharmacokinetics of intravenous linezolid in cerebrospinal fluid and plasma in neurointensive care patients with staphylococcal ventriculitis associated with external ventricular drains. Antimicrob Agents Chemother 2007;51:379-382. (Pubitemid 46047736)
39. Myrianthefs P, Markantonis SL, Vlachos K, et al. Serum and cerebrospinal fluid concentrations of linezolid in neurosurgical patients. Antimicrob Agents Chemother 2006;50:3971-3976. (Pubitemid 44865137)
40. Kim BN, Peleg AY, Lodise TP, et al. Management of meningitis due to antibiotic-resistant Acinetobacter species. Lancet Infect Dis 2009;9:245-255. This article reviews in detail the epidemiology, clinical characteristics, and treatment modalities of postneurosurgical meningitis with Acinetobacter spp.
41. Infection in Neurosurgery Working Party of the British Society of Antimicrobial Chemotherapy. The management of neurosurgical patients with postoperative bacterial or aseptic meningitis or external drain-associated ventriculitis. Br J Neurosurg 2000;14:7-12.
42. Kestle JR, Garton HJ, Whitehead WE, et al. Management of shunt infections: a multicenter pilot study. J Neurosurg 2006;105:177-181. (Pubitemid 44968407)
43. Barker FG 2nd. Efficacy of prophylactic antibiotics against meningitis after craniotomy: a metaanalysis. Neurosurgery 2007;60:887-894. (Pubitemid 46684278)
44. Zabramski JM, Whiting D, Daraouiche RO, et al. Efficacy of antimicrobialimpregnated external ventricular drain catheters: a prospective, randomized, controlled trial. J Neurosurg 2003;98:725-730. (Pubitemid 36396773)
45. Fichtner J, Gueresir E, Seifert V, Raabe A. Efficacy of silver-bearing external ventricular drainage catheters: a retrospective analysis. J Neurosurg 2009. [Epub ahead of print] This contemporary retrospective analysis indicates that silver-bearing external ventricular drainage catheters may reduce the risk of device-related infections in neurosurgical patients.