Two recombinant depressant scorpion neurotoxins differentially affecting mammalian sodium channels

Toxicon

Volumn 55, Issue 8, 2010, Pages 1425-1433

  Yuan, Yuzhe ^a,c   Luo, Lan ^a   Peigneur, Steve ^b   Tytgat, Jan ^b   Zhu, Shunyi ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c INSTITUTE OF BLOOD TRANSFUSION   (China)

Author keywords

BmKITc; BmKITc2; DmNav1 tipE; DRG neurons; Prokaryotic expression

Indexed keywords

BMKITC PROTEIN; BMKITC2 PROTEIN; LYSINE; RECOMBINANT PROTEIN; SCORPION VENOM; TETRODOTOXIN; THREONINE; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; ESCHERICHIA COLI; EXPRESSION VECTOR; FEMALE; MALE; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE SYNTHESIS; POISONOUS SCORPION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; RAT; SEQUENCE ANALYSIS; SODIUM CURRENT; SPINAL GANGLION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TOXIN ANALYSIS; TOXIN STRUCTURE; TOXIN SYNTHESIS; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; CIRCULAR DICHROISM; CLONING, MOLECULAR; FEMALE; GANGLIA, SPINAL; INSECTS; MALE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NEUROTOXINS; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SCORPION VENOMS; SEQUENCE ALIGNMENT; SODIUM CHANNELS; SPECIES SPECIFICITY; XENOPUS LAEVIS;

ESCHERICHIA COLI; HEXAPODA; MAMMALIA; PROKARYOTA; RATTUS; SCORPIONES;

EID: 77952289719     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2010.02.019     Document Type: Article

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