Epstein-Barr virus encoded latent membrane protein 1 regulates mTOR signaling pathway genes which predict poor prognosis of nasopharyngeal carcinoma

Journal of Translational Medicine

Volumn 8, Issue , 2010, Pages

  Chen, Jing ^a,b   Hu, Chun Fang ^c   Hou, Jing Hui ^a   Shao, Qiong ^a   Yan, Li Xu ^a   Zhu, Xiao Feng ^a   Zeng, Yi Xin ^a   Shao, Jian Yong ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 4E BINDING PROTEIN 1; LATENT MEMBRANE PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; S6 KINASE; EBV ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN BARR VIRUS; EBV-ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN-BARR VIRUS; MATRIX PROTEIN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; NASOPHARYNX CARCINOMA; NUCLEOTIDE SEQUENCE; OVERALL SURVIVAL; PREDICTION; PROGNOSIS; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SURVIVAL RATE; UPREGULATION; WESTERN BLOTTING; ADOLESCENT; DNA MICROARRAY; GENE SILENCING; GENETICS; KAPLAN MEIER METHOD; METABOLISM; MIDDLE AGED; NASOPHARYNX TUMOR; PROPORTIONAL HAZARDS MODEL; TUMOR CELL LINE; VIROLOGY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; VIRAL MATRIX PROTEINS; YOUNG ADULT;

EID: 77952257255     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-8-30     Document Type: Article

References (35)

1. Busson P, Keryer C, Ooka T, Corbex M. EBV-associated nasopharyngeal carcinomas: from epidemiology to virus-targeting strategies. Trends in microbiology 2004, 12(8):356-360. 10.1016/j.tim.2004.06.005, 15276610.
2. Chan AT, Teo PM, Johnson PJ. Nasopharyngeal carcinoma. Ann Oncol 2002, 13(7):1007-1015. 10.1093/annonc/mdf179, 12176778.
3. Young LS, Murray PG. Epstein-Barr virus and oncogenesis: from latent genes to tumours. Oncogene 2003, 22(33):5108-5121. 10.1038/sj.onc.1206556, 12910248.
4. Tsao SW, Tramoutanis G, Dawson CW, Lo AK, Huang DP. The significance of LMP1 expression in nasopharyngeal carcinoma. Seminars in cancer biology 2002, 12(6):473-487. 10.1016/S1044579X02000901, 12450733.
5. Yoshizaki T, Sato H, Murono S, Pagano JS, Furukawa M. Matrix metalloproteinase 9 is induced by the Epstein-Barr virus BZLF1 transactivator. Clinical & experimental metastasis 1999, 17(5):431-436.
6. Zheng H, Li LL, Hu DS, Deng XY, Cao Y. Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma. Cellular & molecular immunology 2007, 4(3):185-196.
7. Mainou BA, Everly DN, Raab-Traub N. Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K. Oncogene 2005, 24(46):6917-6924. 10.1038/sj.onc.1208846, 16007144.
8. Dawson CW, Tramountanis G, Eliopoulos AG, Young LS. Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling. The Journal of biological chemistry 2003, 278(6):3694-3704. 10.1074/jbc.M209840200, 12446712.
9. Dawson CW, Laverick L, Morris MA, Tramoutanis G, Young LS. Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway. Journal of virology 2008, 82(7):3654-3664. 10.1128/JVI.01888-07, 2268486, 18199641.
10. Tsang CK, Qi H, Liu LF, Zheng XF. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug discovery today 2007, 12(3-4):112-124. 10.1016/j.drudis.2006.12.008, 17275731.
11. Goberdhan DC, Boyd CA. mTOR: dissecting regulation and mechanism of action to understand human disease. Biochemical Society transactions 2009, 37(Pt 1):213-216. 10.1042/BST0370213, 2639772, 19143634.
12. Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes & development 2004, 18(16):1926-1945.
13. Min H, Hong M, Ma J, Zhang E, Zheng Q, Zhang J, Zhang J, Zhang F, Su Y, Qiu F. A new staging system for nasopharyngeal carcinoma in China. International journal of radiation oncology, biology, physics 1994, 30(5):1037-1042.
14. Li YH, Hu CF, Shao Q, Huang MY, Hou JH, Xie D, Zeng YX, Shao JY. Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma. Journal of translational medicine 2008, 6:1. 10.1186/1479-5876-6-1, 2254380, 18171482.
15. Lan K, Ren CP XL, He ZW, Gan RL, Yao KT. Comparison Study on Tumorigenicity of Two Different LMP1 Isolates. Chinese Journal of Cancer 2001, 20(10):1033-1037.
16. Yu J, Zhang L, Chen A, Xiang G, Wang Y, Wu J, Mitchelson K, Cheng J, Zhou Y. Identification of the gene transcription and apoptosis mediated by TGF-beta-Smad2/3-Smad4 signaling. Journal of cellular physiology 2008, 215(2):422-433. 10.1002/jcp.21325, 17960585.
17. Yang YH, Dudoit S, Luu P, Lin DM, Peng V, Ngai J, Speed TP. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic acids research 2002, 30(4):e15. 10.1093/nar/30.4.e15, 100354, 11842121.
18. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, Calif) 2001, 25(4):402-408.
19. Li J, Zhang XS, Xie D, Deng HX, Gao YF, Chen QY, Huang WL, Masucci MG, Zeng YX. Expression of immune-related molecules in primary EBV-positive Chinese nasopharyngeal carcinoma: associated with latent membrane protein 1 (LMP1) expression. Cancer biology & therapy 2007, 6(12):1997-2004.
20. Mei YP, Zhu XF, Zhou JM, Huang H, Deng R, Zeng YX. siRNA targeting LMP1-induced apoptosis in EBV-positive lymphoma cells is associated with inhibition of telomerase activity and expression. Cancer letters 2006, 232(2):189-198. 10.1016/j.canlet.2005.02.010, 16458115.
21. Lambert SL, Martinez OM. Latent membrane protein 1 of EBV activates phosphatidylinositol 3-kinase to induce production of IL-10. J Immunol 2007, 179(12):8225-8234.
22. Moody CA, Scott RS, Amirghahari N, Nathan CA, Young LS, Dawson CW, Sixbey JW. Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A. Journal of virology 2005, 79(9):5499-5506. 10.1128/JVI.79.9.5499-5506.2005, 1082717, 15827164.
23. Huang XM, Dai CB, Mou ZL, Wang LJ, Wen WP, Lin SG, Xu G, Li HB. Overproduction of cyclin D1 is dependent on activated mTORC1 signal in nasopharyngeal carcinoma: implication for therapy. Cancer letters 2009, 279(1):47-56. 10.1016/j.canlet.2009.01.020, 19203829.
24. Li HM, Zhuang ZH, Wang Q, Pang JC, Wang XH, Wong HL, Feng HC, Jin DY, Ling MT, Wong YC, et al. Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells. Oncogene 2004, 23(25):4488-4494. 10.1038/sj.onc.1207580, 15064751.
25. Faqing T, Zhi H, Liqun Y, Min T, Huanhua G, Xiyun D, Ya C. Epstein-Barr virus LMP1 initiates cell proliferation and apoptosis inhibition via regulating expression of Survivin in nasopharyngeal carcinoma. Experimental oncology 2005, 27(2):96-101.
26. Murayama T, Inokuchi M, Takagi Y, Yamada H, Kojima K, Kumagai J, Kawano T, Sugihara K. Relation between outcomes and localisation of p-mTOR expression in gastric cancer. British journal of cancer 2009, 100(5):782-788. 10.1038/sj.bjc.6604915, 2653759, 19223902.
27. Faried LS, Faried A, Kanuma T, Aoki H, Sano T, Nakazato T, Tamura T, Kuwano H, Minegishi T. Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy. Molecular carcinogenesis 2008, 47(6):446-457. 10.1002/mc.20402, 18058806.
28. Pelloski CE, Lin E, Zhang L, Yung WK, Colman H, Liu JL, Woo SY, Heimberger AB, Suki D, Prados M, et al. Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma. Clin Cancer Res 2006, 12(13):3935-3941. 10.1158/1078-0432.CCR-05-2202, 16818690.
29. Rojo F, Najera L, Lirola J, Jimenez J, Guzman M, Sabadell MD, Baselga J, Ramon Y, Cajal S. 4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis. Clin Cancer Res 2007, 13(1):81-89. 10.1158/1078-0432.CCR-06-1560, 17200342.
30. Castellvi J, Garcia A, Rojo F, Ruiz-Marcellan C, Gil A, Baselga J, Ramon Y, Cajal S. Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer. Cancer 2006, 107(8):1801-1811. 10.1002/cncr.22195, 16983702.
31. Horikawa T, Sheen TS, Takeshita H, Sato H, Furukawa M, Yoshizaki T. Induction of c-Met proto-oncogene by Epstein-Barr virus latent membrane protein-1 and the correlation with cervical lymph node metastasis of nasopharyngeal carcinoma. The American journal of pathology 2001, 159(1):27-33. 1850422, 11438450.
32. Jeon YK, Lee BY, Kim JE, Lee SS, Kim CW. Molecular characterization of Epstein-Barr virus and oncoprotein expression in nasopharyngeal carcinoma in Korea. Head & neck 2004, 26(7):573-583.
33. Shao JY, Ernberg I, Biberfeld P, Heiden T, Zeng YX, Hu LF. Epstein-Barr virus LMP1 status in relation to apoptosis, p53 expression and leucocyte infiltration in nasopharyngeal carcinoma. Anticancer research 2004, 24(4):2309-2318.
34. Hu LF, Chen F, Zhen QF, Zhang YW, Luo Y, Zheng X, Winberg G, Ernberg I, Klein G. Differences in the growth pattern and clinical course of EBV-LMP1 expressing and non-expressing nasopharyngeal carcinomas. Eur J Cancer 1995, 31A(5):658-660. 10.1016/0959-8049(94)00468-K, 7640034.
35. Sarac S, Akyol MU, Kanbur B, Poyraz A, Akyol G, Yilmaz T, Sungur A. Bcl-2 and LMP1 expression in nasopharyngeal carcinomas. American journal of otolaryngology 2001, 22(6):377-382. 10.1053/ajot.2001.28071, 11713720.