Retrograde Flush Following Warm Ischemia in the Non-Heart-Beating Donor Results in Superior Graft Performance at Reperfusion

Journal of Surgical Research

Volumn 154, Issue 1, 2009, Pages 118-125

  Van De Wauwer, Caroline ^a   Neyrinck, Arne P ^a   Geudens, Nele ^a   Rega, Filip R ^a   Verleden, Geert M ^a   Verbeken, Erik ^b   Lerut, Toni E ^b   Van Raemdonck, Dirk E M ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

lung transplantation; non heart beating donor; pulmonary flush

Indexed keywords

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOMESTIC ANIMAL; DRY WEIGHT; EX VIVO STUDY; FLUSHING; GRAFT SURVIVAL; HEART LEFT ATRIUM; HEART VENTRICLE FIBRILLATION; HISTOPATHOLOGY; ISCHEMIA; LUNG COMPLIANCE; LUNG VASCULAR RESISTANCE; MICROTHROMBUS; NON HEART BEATING DONOR; NONHUMAN; ORGAN DONOR; OXYGENATION; PRIORITY JOURNAL; PULMONARY ARTERY; REPERFUSION; SWINE; WET DEPOSITION;

ANIMALS; CADAVER; HEART; HUMANS; LUNG; LUNG COMPLIANCE; LUNG TRANSPLANTATION; ORGAN PRESERVATION; POSITIVE-PRESSURE RESPIRATION; PULMONARY ARTERY; PULMONARY CIRCULATION; PULMONARY EMBOLISM; REPERFUSION; SWINE; TISSUE DONORS; TREATMENT FAILURE; VASCULAR RESISTANCE;

EID: 67349171827     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2008.06.007     Document Type: Article

References (35)

1. Hardy J.D., Webb W.R., Dalton Jr. M.L., et al. Lung homotransplantation in man. JAMA 186 (1963) 1065
2. Trulock E.P., Edwards L.B., Taylor D.O., et al. Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth official adult lung and heart-lung transplant report-2006. J Heart Lung Transplant 26 (2007) 782
3. Egan T.M., Boychuk J.E., Rosato K., et al. Whence the lungs?. A study to assess suitability of donor lungs for transplantation. Transplantation 53 (1992) 420
4. Van Raemdonck D.E.M., Coosemans W., Klepetko W., et al. Alternatives to lung donor shortage. Eur Respir Mon 29 (2004) 89
5. Van Raemdonck D.E., Rega F.R., Neyrinck A.P., et al. Non-heart-beating donors. Semin Thorac Cardiovasc Surg 16 (2004) 309
6. Egan T.M., Lambert Jr. C.J., Reddick R., et al. A strategy to increase the donor pool: Use of cadaver lungs for transplantation. Ann Thorac Surg 52 (1991) 1113
7. Rega F.R., Jannis N.C., Verleden G.M., et al. Long-term preservation with interim evaluation of lungs from a non-heart-beating donor after a warm ischemic interval of 90 minutes. Ann Surg 238 (2003) 782
8. Steen S., Sjoberg T., Pierre L., et al. Transplantation of lungs from a non-heart-beating donor. Lancet 357 (2001) 825
9. Nunez J.R., Varela A., del Rio F., et al. Bipulmonary transplants with lungs obtained from two non-heart-beating donors who died out of hospital. J Thorac Cardiovasc Surg 127 (2004) 297
10. Gamez P., Cordoba M., Ussetti P., et al. Lung transplantation from out-of-hospital non-heart-beating lung donors: One-year experience and results. J Heart Lung Transplant 24 (2005) 1098
11. de Antonio D.G., Marcos R., Laporta R., et al. Results of clinical lung transplantation from uncontrolled non-heart-beating donors. J Heart Lung Transplant 26 (2007) 529
12. Venuta F., Rendina E.A., Bufi M., et al. Preimplantation retrograde pneumoplegia in clinical lung transplantation. J Thorac Cardiovasc Surg 118 (1999) 107
13. Kootstra G., Daemen J.H., and Oomen A.P. Categories of non-heart-beating donors. Transplant Proc 27 (1995) 2893
14. Van De Wauwer C., Neyrinck A.P., Geudens N., et al. Retrograde flush following topical cooling is superior to preserve the non-heart-beating donor lung. Eur J Cardiothorac Surg 31 (2007) 1125
15. Date H., Matsumura A., Manchester J.K., et al. Changes in alveolar oxygen and carbon dioxide concentration and oxygen consumption during lung preservation. The maintenance of aerobic metabolism during lung preservation. J Thorac Cardiovasc Surg 105 (1993) 492
16. D'Armini A.M., Roberts C.S., Griffith P.K., et al. When does the lung die? I. Histochemical evidence of pulmonary viability after "death.". J Heart Lung Transplant 13 (1994) 741
17. Varela A., Cordoba M., Serrano-Fiz S., et al. Early lung allograft function after retrograde and anterograde preservation. J Thorac Cardiovasc Surg 114 (1997) 1119
18. Baretti R., Bitu-Moreno J., Beyersdorf F., et al. Distribution of lung preservation solutions in parenchyma and airways: Influence of atelectasis and route of delivery. J Heart Lung Transplant 14 (1995) 80
19. Chen C.Z., Gallagher R.C., Ardery P., et al. Retrograde versus antegrade flush in canine left lung preservation for six hours. J Heart Lung Transplant 15 (1996) 395
20. Struber M., Hohlfeld J.M., Kofidis T., et al. Surfactant function in lung transplantation after 24 hours of ischemia: Advantage of retrograde flush perfusion for preservation. J Thorac Cardiovasc Surg 123 (2002) 98
21. Wittwer T., Franke U., Fehrenbach A., et al. Impact of retrograde graft preservation in Perfadex-based experimental lung transplantation. J Surg Res 117 (2004) 239
22. Kofidis T., Struber M., Warnecke G., et al. Antegrade versus retrograde perfusion of the donor lung: Impact on the early reperfusion phase. Transplant Int 16 (2003) 801
23. Wittwer T., Franke U.F., Fehrenbach A., et al. Experimental lung transplantation: Impact of preservation solution and route of delivery. J Heart Lung Transplant 24 (2005) 1081
24. Sarsam M.A., Yonan N.A., Deiraniya A.K., et al. Retrograde pulmonaryplegia for lung preservation in clinical transplantation: A new technique. J Heart Lung Transplant 12 (1993) 494
25. Ware L.B., Fang X., Wang Y., et al. High prevalence of pulmonary arterial thrombi in lungs rejected for transplantation. J Heart Lung Transplant 24 (2005) 1650
26. Hayama M., Date H., Oto T., et al. Improved lung function by means of retrograde flush in canine lung transplantation with non-heart-beating donors. J Thorac Cardiovasc Surg 125 (2003) 901
27. Luh S.P., Tsai C.C., Shau W.Y., et al. The effects of inhaled nitric oxide, gabexate mesilate, and retrograde flush in the lung graft from non-heart beating minipig donors. Transplantation 69 (2000) 2019
28. Ulicny Jr. K.S., Egan T.M., Lambert Jr. C.J., et al. Cadaver lung donors: Effect of preharvest ventilation on graft function. Ann Thorac Surg 55 (1993) 1185
29. Wittwer T., Franke U.F., Fehrenbach A., et al. Lung retrieval from non-heart-beating donors: First experience with an innovative preservation strategy in a pig lung transplantation model. Eur Surg Res 36 (2004) 1
30. Wittwer T., Franke U.F., Fehrenbach A., et al. Innovative pulmonary preservation of non-heart-beating donor grafts in experimental lung transplantation. Eur J Cardiothorac Surg 26 (2004) 144
31. Inokawa H., Date H., Okazaki M., et al. Effects of postmortem heparinization in canine lung transplantation with non-heart-beating donors. J Thorac Cardiovasc Surg 129 (2005) 429
32. Umemori Y., Date H., Uno K., et al. Improved lung function by urokinase infusion in canine lung transplantation using non-heart-beating donors. Ann Thorac Surg 59 (1995) 1513
33. Inci I., Zhai W., Arni S., et al. Fibrinolytic treatment improves the quality of lungs retrieved from non-heart-beating donors. J Heart Lung Transplant 26 (2007) 1054
34. Wang L.S., Nakamoto K., Hsieh C.M., et al. Influence of temperature of flushing solution on lung preservation. Ann Thorac Surg 55 (1993) 711
35. Steen S., Sjoberg T., Ingemansson R., et al. Efficacy of topical cooling in lung preservation: Is a reappraisal due?. Ann Thorac Surg 58 (1994) 1657