Reduced retinal blood flow velocity in diabetic retinopathy

Retina

Volumn 30, Issue 5, 2010, Pages 765-773

  Burgansky Eliash, Zvia ^a,b   Nelson, Darin A ^b   Bar Tal, Orly Pupko ^b   Lowenstein, Anat ^c   Grinvald, Amiram ^d   Barak, Adiel ^c  

^a WOLFSON MEDICAL CENTER   (Israel)

^b Optical Imaging   (Israel)

^c TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^d WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Blood flow; Diabetic retinopathy; Flow velocity; Imaging; Retinal function imager (RFI)

Indexed keywords

ADULT; ARTICLE; BLOOD FLOW VELOCITY; BLOOD VESSEL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC MACULAR EDEMA; DIABETIC RETINOPATHY; FEMALE; HEART RATE; HUMAN; INTRAOCULAR PRESSURE; LOW LEVEL LASER THERAPY; MALE; NON INVASIVE PROCEDURE; PERFUSION PRESSURE; RETINA ARTERY; RETINA BLOOD FLOW; VENULE; VISUAL ACUITY;

BLOOD FLOW VELOCITY; BLOOD PRESSURE; CROSS-SECTIONAL STUDIES; DIABETIC RETINOPATHY; FEMALE; HEART RATE; HUMANS; INTRAOCULAR PRESSURE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; REGIONAL BLOOD FLOW; RETINAL ARTERY; RETINAL VEIN; VISUAL ACUITY;

EID: 77952253377     PISSN: 0275004X     EISSN: None     Source Type: Journal    
DOI: 10.1097/IAE.0b013e3181c596c6     Document Type: Article

References (41)

1. Paget C, Lecomte M, Ruggiero D, Wiernsperger N, Lagarde M. Modification of enzymatic antioxidants in retinal microvascular cells by glucose or advanced glycation end products. Free Radic Biol Med 1998;25:121-129.
2. Ansari NH, Zhang W, Fulep E, Mansour A. Prevention of pericyte loss by Trolox in diabetic rat retina. J Toxicol Environ Health A 1998;54:467-475.
3. Dodge AB, D'Amore PA. Cell-cell interactions in diabetic angiopathy. Diabetes Care 1992;15:1168-1180.
4. Riva CE, Sinclair SH, Grunwald JE. Autoregulation of retinal circulation in response to decrease of perfusion pressure. Invest Ophthalmol Vis Sci 1981;21:34-38.
5. Robinson F, Riva CE, Grunwald JE, Petrig BL, Sinclair SH. Retinal blood flow autoregulation in response to an acute increase in blood pressure. Invest Ophthalmol Vis Sci 1986;27:722-726.
6. Shepro D, Morel NM. Pericyte physiology. FASEB J 1993;7:1031-1038.
7. Haefliger IO, Anderson DR. Oxygen modulation of guanylate cyclase-mediated retinal pericyte relaxations with 3-morpholino-sydnonimine and atrial natriuretic peptide. Invest Ophthalmol Vis Sci 1997;38:1563-1568.
8. Matsugi T, Chen Q, Anderson DR. Adenosine-induced relaxation of cultured bovine retinal pericytes. Invest Ophthalmol Vis Sci 1997;38:2695-2701. (Pubitemid 28009390)
9. Matsugi T, Chen Q, Anderson DR. Suppression of CO2-induced relaxation of bovine retinal pericytes by angiotensin II. Invest Ophthalmol Vis Sci 1997;38:652-657. (Pubitemid 27143136)
10. Sims DE. The pericyte-a review. Tissue Cell 1986;18:153-174.
11. Gillies MC, Su T. High glucose inhibits retinal capillary pericyte contractility in vitro. Invest Ophthalmol Vis Sci 1993;34:3396-3401.
12. de la Rubia G, Oliver FJ, Inoguchi T, King GL. Induction of resistance to endothelin-1's biochemical actions by elevated glucose levels in retinal pericytes. Diabetes 1992;41:1533-1539.
13. King GL, Shiba T, Oliver J, Inoguchi T, Bursell SE. Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus. Annu Rev Med 1994;45:179-188.
14. Bursell SE, Takagi C, Clermont AC, et al. Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats. Invest Ophthalmol Vis Sci 1997;38:2711-2720.
15. Joussen AM, Poulaki V, Tsujikawa A, et al. Suppression of diabetic retinopathy with angiopoietin-1. Am J Pathol 2002;160:1683-1693.
16. van Hecke MV, Dekker JM, Nijpels G, et al. Are retinal microvascular abnormalities associated with large artery endothelial dysfunction and intima-media thickness? The Hoorn Study. Clin Sci (Lond) 2006;110:597-604.
17. van den Born BJ, Hulsman CA, Hoekstra JB, Schlingemann RO, van Montfrans GA. Value of routine funduscopy in patients with hypertension: systematic review. BMJ 2005;331:73.
18. Grinvald A, Bonhoeffer T, Vanzetta I, et al. High-resolution functional optical imaging: from the neocortex to the eye. Ophthalmol Clin North Am 2004;17:53-67.
19. Nelson DA, Krupsky S, Pollack A, et al. Special report: noninvasive multi-parameter functional optical imaging of the eye. Ophthalmic Surg Lasers Imaging 2005;36:57-66.
20. Abramoff MD, Kwon YH, Ts'o D, et al. Visual stimulusinduced changes in human near-infrared fundus reflectance. Invest Ophthalmol Vis Sci 2006;47:715-721.
21. Hanazono G, Tsunoda K, Shinoda K, Tsubota K, Miyake Y, Tanifuji M. Intrinsic signal imaging in macaque retina reveals different types of flash-induced light reflectance changes of different origins. Invest Ophthalmol Vis Sci 2007;48:2903-2912.
22. Landa G, Garcia PM, Rosen RB. Correlation between retina blood flow velocity assessed by retinal function imager and retina thickness estimated by scanning laser ophthalmoscopy/optical coherence tomography. Ophthalmologica 2009;223:155-161.
23. Grading diabetic retinopathy from stereoscopic color fundus photographs-an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology 1991;98:786-806.
24. Grinvald A, Lieke E, Frostig RD, Gilbert CD, Wiesel TN. Functional architecture of cortex revealed by optical imaging of intrinsic signals. Nature 1986;324:361-364.
25. Kohner EM, Hamilton AM, Saunders SJ, Sutcliffe BA, Bulpitt CJ. The retinal blood flow in diabetes. Diabetologia 1975;11:27-33.
26. Cuypers MH, Kasanardjo JS, Polak BC. Retinal blood flow changes in diabetic retinopathy measured with the Heidelberg scanning laser Doppler flowmeter. Graefes Arch Clin Exp Ophthalmol 2000;238:935-941.
27. Jeppesen P, Bek T. Impaired retinal autoregulation in small retinal arterioles before and after focal laser treatment for diabetic maculopathy. Br J Ophthalmol 2006;90:198-201.
28. Guan K, Hudson C, Wong T, et al. Retinal hemodynamics in early diabetic macular edema. Diabetes 2006;55:813-818.
29. Arend O, Remky A, Harris A, Bertram B, Reim M, Wolf S. Macular microcirculation in cystoid maculopathy of diabetic patients. Br J Ophthalmol 1995;79:628-632.
30. Sakata K, Funatsu H, Harino S, Noma H, Hori S. Relationship between macular microcirculation and progression of diabetic macular edema. Ophthalmology 2006;113:1385-1391.
31. Frederiksen CA, Jeppesen P, Knudsen ST, Poulsen PL, Mogensen CE, Bek T. The blood pressure-induced diameter response of retinal arterioles decreases with increasing diabetic maculopathy. Graefes Arch Clin Exp Ophthalmol 2006;244:1255-1261.
32. Sinclair SH, Grunwald JE, Riva CE, Braunstein SN, Nichols CW, Schwartz SS. Retinal vascular autoregulation in diabetes mellitus. Ophthalmology 1982;89:748-750.
33. Grunwald JE, Riva CE, Sinclair SH, Brucker AJ, Petrig BL. Laser Doppler velocimetry study of retinal circulation in diabetes mellitus. Arch Ophthalmol 1986;104:991-996.
34. Hudson C, Flanagan JG, Turner GS, Chen HC, Rawji MH, McLeod D. Exaggerated relative nasal-temporal asymmetry of macular capillary blood flow in patients with clinically significant diabetic macular oedema. Br J Ophthalmol 2005;89:142-146.
35. Yoshida A, Feke GT, Morales-Stoppello J, Collas GD, Goger DG, McMeel JW. Retinal blood flow alterations during progression of diabetic retinopathy. Arch Ophthalmol 1983;101:225-227.
36. Arend O, Wolf S, Jung F, et al. Retinal microcirculation in patients with diabetes mellitus: dynamic and morphological analysis of perifoveal capillary network. Br J Ophthalmol 1991;75:514-518.
37. Blair NP, Feke GT, Morales-Stoppello J, et al. Prolongation of the retinal mean circulation time in diabetes. Arch Ophthalmol 1982;100:764-768.
38. Grunwald JE, DuPont J, Riva CE. Retinal haemodynamics in patients with early diabetes mellitus. Br J Ophthalmol 1996;80:327-331.
39. Grieshaber MC, Flammer J. Blood flow in glaucoma. Curr Opin Ophthalmol 2005;16:79-83.
40. McMillan DE. Deterioration of the microcirculation in diabetes. Diabetes 1975;24:944-957.
41. McMillan DE. Rheological and related factors in diabetic retinopathy. Int Ophthalmol Clin 1978;18:35-53.