Experimental evaluation of ebastine, a second-generation anti-histamine, as a supportive medication for alopecia areata

Journal of Dermatological Science

Volumn 58, Issue 2, 2010, Pages 154-157

  Ohyama, Manabu ^a   Shimizu, Atsushi ^a   Tanaka, Kyoko ^a   Amagai, Masayuki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Alopecia areata; Anti histamine; Ebastine; Mast cell; Treatment

Indexed keywords

EBASTINE; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; SUBSTANCE P; TUMOR NECROSIS FACTOR ALPHA;

ALOPECIA AREATA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; HAIR GROWTH; HISTOPATHOLOGY; IMMUNE RESPONSE; IN VIVO STUDY; LETTER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ADULT; ALOPECIA AREATA; ANIMALS; BUTYROPHENONES; DISEASE MODELS, ANIMAL; FEMALE; HISTAMINE ANTAGONISTS; HUMANS; IMMUNOTHERAPY; MICE; MICE, INBRED C3H; PIPERIDINES; REMISSION INDUCTION; TREATMENT OUTCOME;

EID: 77952236928     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2010.03.009     Document Type: Letter

References (10)

1. MacDonald Hull S.P., Wood M.L., Hutchinson P.E., Sladden M., Messenger A.G. Guidelines for the management of alopecia areata. Br J Dermatol 2003, 149:692-699.
2. Ogawa H., Imai R., Nishiyama S., Nakajima H., Ikezawa Z., Tokuda Y., et al. The effect of an anti-allergic drug on the disease activity of alopecia areata. Skin Res 1994, 36:60-68. [in Japanese].
3. Yoshizawa Y., Kawana S. Efficacy of ebasitne in the treatment of alopecia areata. Jpn J Dermatol 2005, 115:1473-1480. [in Japanese].
4. Inui S., Nakajima T., Toda N., Itami S. Fexofenadine hydrochloride enhances the efficacy of contact immunotherapy for extensive alopecia areata: retrospective analysis of 121 cases. J Dermatol 2009, 36:323-327.
5. Nori M., Iwata S., Munakata Y., Kobayashi H., Kobayashi S., Umezawa Y., et al. Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines. Clin Exp Allergy 2003, 33:1544-1554.
6. Gilhar A., Paus R., Kalish R.S. Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest 2007, 117:2019-2027.
7. Sundberg J.P., Cordy W.R., King L.E. Alopecia areata in aging C3H/HeJ mice. J Invest Dermatol 1994, 102:847-856.
8. Siebenhaar F., Sharov A.A., Peters E.M., Sharova T.Y., Syska W., Mardaryev A.N., et al. Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata). J Invest Dermatol 2007, 127:1489-1497.
9. Tanii T., Okada T., Fukai K., Nakagawa K., Hamada T. Increase of mast cells in the alopecia lesion of mice. Acta Derm Venereol 1985, 65:64-66.
10. Elston D.M., McCollough M.L., Bergfeld W.F., Liranzo M.O., Heibel M. Eosinophils in fibrous tracts and near hair bulbs: a helpful diagnostic feature of alopecia areata. J Am Acad Dermatol 1997, 37:101-106.