Expression of the Fas-ligand gene in ejaculated sperm from adolescents with and without varicocele

Journal of Assisted Reproduction and Genetics

Volumn 27, Issue 2-3, 2010, Pages 103-109

  Del Giudice, Paula Toni ^a   Lima, Samira Barbosa ^a   Cenedeze, Marcos Antonio ^a   Pacheco Silva, Álvaro ^a   Bertolla, Ricardo Pimenta ^a   Cedenho, Agnaldo Pereira ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Adolescent; Apoptosis; Fas ligand; Sperm; Varicocele

Indexed keywords

CYCLOPHILIN A; FAS LIGAND; MESSENGER RNA;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EJACULATION; GENE EXPRESSION; HOUSEKEEPING GENE; HUMAN; MALE; MASTURBATION; MORPHOLOGY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMEN ANALYSIS; SPERM; SPERMATOZOON DENSITY; VARICOCELE;

ADOLESCENT; APOPTOSIS; COMPUTER SYSTEMS; EJACULATION; FAS LIGAND PROTEIN; HUMANS; MALE; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEMEN ANALYSIS; SPERMATOZOA; VARICOCELE; YOUNG ADULT;

EID: 77952236607     PISSN: 10580468     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10815-010-9384-9     Document Type: Article

References (61)

1. DB French NR Desai A Agarwal 2008 Varicocele repair: Does it still have a role in infertility treatment? Curr Opin Obstet Gynecol. 20 269 74 10.1097/GCO.0b013e3282fcc00c 18460942 (Pubitemid 351643515)
2. CK Naughton AK Nangia A Agarwal 2001 Pathophysiology of varicoceles in male infertility Hum Reprod Updat. 7 473 81 10.1093/humupd/7.5.473 1:STN:280:DC%2BD3MrgvVSlsw%3D%3D (Pubitemid 32827547)
3. DA Paduch SJ Skoog 2001 Current management of adolescent varicocele Rev Urol. 3 3 120 33 1:STN:280:DC%2BD28rmtVSgtQ%3D%3D 16985704
4. N Guarino B Tadini M Bianchi 2003 The adolescent varicocele: the crucial role of hormonal tests in selecting patients with testicular dysfunction J Pediatr Surg. 38 1 120 3 10.1053/jpsu.2003.50024 12592633 (Pubitemid 36109901)
5. SJ Skoog KP Roberts M Goldstein JL Pryor 1997 The adolescent varicocele: what's new with an old problem in young patients? Pediatrics. 100 1 112 21 10.1542/peds.100.1.112 1:STN:280:DyaK2szksF2ltA%3D%3D 9200369 (Pubitemid 27291017)
6. L Lund HH Rasmussen E Ernst 1993 Asymptomatic varicocele testis Scand J Urol Nephrol. 27 395 8 10.3109/00365599309180452 1:STN:280:DyaK2c7itVeluw%3D%3D 8290920
7. O Steeno J Knops L Declerck A Adimoelja H van de Voorde 1976 Prevention of fertility disorders by detection and treatment of varicocele at school and college age Andrologia. 8 47 53 1:STN:280:DyaE283ltV2iuw%3D%3D 986121
8. MM Mori RP Bertolla R Fraietta V Ortiz AP Cedenho 2008 Does varicocele grade determine extent of alteration to spermatogenesis in adolescents? Fertil Steril. 90 5 1769 73 10.1016/j.fertnstert.2007.09.052 18166185
9. The influence of varicocele on parameters of fertility in a large group of men presenting to infertility clinics. World Health Organization. Fertil Steril. 1992;57(6):1289-93.
10. F Hadziselimovic B Herzog P Jenny 1995 The chance for fertility in adolescent boys after corrective surgery for varicocele J Urol. 154 731 3 10.1016/S0022-5347(01)67147-7 1:STN:280:DyaK2MzjtlCjsw%3D%3D 7609165
11. D Sakkas O Moffatt GC Manicardi E Mariethoz N Tarozzi D Bizzaro 2002 Nature of DNA damage in ejaculated human spermatozoa and the possible involvement of apoptosis Biol Reprod. 66 4 1061 7 10.1095/biolreprod66.4.1061 1:CAS:528:DC%2BD38XitlCluro%3D 11906926
12. RA Saleh A Agarwal RK Sharma TM Said SC Sikka AJ Thomas 2003 Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele Fertil Steril. 80 6 1431 6 10.1016/S0015-0282(03)02211-8 14667879 (Pubitemid 37532458)
13. M Blank Y Shiloh 2007 Programs for cell death: apoptosis is only one way to go Cell Cycle. 6 686 95 1:CAS:528:DC%2BD2sXnvFCltLc%3D 17361099
14. G Liu P Gong LR Bernstein Y Bi S Gong L Cai 2007 Apoptotic cell death induced by low-dose radiation in male germ cells: hormesis and adaptation Crit Rev Toxicol. 37 587 605 10.1080/10408440701493061 1:CAS:528:DC%2BD2sXosVKgtbs%3D 17674213 (Pubitemid 47221536)
15. D Arnoult P Parone JC Martinou B Antonsson J Estaquier JC Ameisen 2002 Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli J Cell Biol. 159 923 9 10.1083/jcb.200207071 1:CAS:528:DC%2BD3sXjt1aj 12486111 (Pubitemid 36055747)
16. JE Chipuk DR Green 2005 Do inducers of apoptosis trigger caspase-independent cell death? Nat Rev Mol Cell Biol. 6 268 75 10.1038/nrm1573 1:CAS:528:DC%2BD2MXhslSlsLw%3D 15714200 (Pubitemid 40314927)
17. JJ Lysiak SD Turner TT Turner 2000 Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis Biol Reprod. 63 1465 72 10.1095/biolreprod63.5.1465 1:CAS:528:DC%2BD3cXnslCktb4%3D 11058553
18. J Lee JH Richburg EB Shipp ML Meistrich K Boekelheide 1999 The Fas system, a regulator of testicular germ cells apoptosis is differentially up-regulated in Sertoli versus germ cells injury of the testis Endocrinology. 140 852 8 10.1210/en.140.2.852 1:CAS:528:DyaK1MXntl2nug%3D%3D 9927315 (Pubitemid 29058222)
19. EJ Fuchs KA McKenna A Bedi 1997 p53-dependent DNA damage-induced apoptosis requires FAS/APO-1 independent activation of CPP32 beta Cancer Res. 57 2250 554
20. JL Marmar 2001 The pathophysiology of varicoceles in the light of current molecular and genetic information Hum Reprod Updat. 7 5 461 72 10.1093/humupd/7.5.461 1:CAS:528:DC%2BD3MXnslKrurk%3D (Pubitemid 32827546)
21. A Bartke 1995 Apoptosis of male germ cells, a generalized or a cell type-specific phenomenon? Endocrinology. 136 3 4 10.1210/en.136.1.3 1:CAS:528:DyaK2MXjt1Knsb8%3D 7828545
22. DJ Allan BV Harmon SA Roberts 1992 Spermatogonial apoptosis has three morphologically recognizable phases and shows no circadian rhythm during normal spermatogenesis in the rat Cell Prolif. 25 241 50 10.1111/j.1365-2184.1992. tb01399.x 1:STN:280:DyaK383ot1ShsQ%3D%3D 1596537
23. AP Sinha Hikim TB Rajavashisth I Sinha Hikim Y Lue JJ Bonavera A Leung, et al. 1997 Significance of apoptosis in the temporal and stage-specific loss of germ cells in the adult rat after gonadotropin deprivation Biol Reprod. 57 1193 1201 10.1095/biolreprod57.5.1193 1:STN:280:DyaK1c%2FjsVWhsg%3D%3D 9369187 (Pubitemid 27461213)
24. I Rodriguez C Ody K Araki I Garcia P Vassalli 1997 An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis EMBO J. 16 2262 70 10.1093/emboj/16.9.2262 1:CAS:528: DyaK2sXjsV2nu7Y%3D 9171341 (Pubitemid 27260376)
25. M Fujisawa C Hiramine H Tanaka H Okada S Arakawa S Kamidono 1999 Decrease in apoptosis of germ cells in the testes of infertile men with varicocele World J Urol. 17 296 300 10.1007/s003450050149 1:STN:280:DC%2BD3c%2FhvF2gtA%3D%3D 10552147
26. AP Hikim C Wang Y Lue L Johnson XH Wang RS Swerdloff 1998 Spontaneous germ cell apoptosis in humans: evidence for ethnic differences in the susceptibility of germ cells to programmed cell death J Clin Endocrinol Metab. 83 152 6 10.1210/jc.83.1.152 1:CAS:528:DyaK1cXit1Gqtg%3D%3D 9435433 (Pubitemid 28498327)
27. D Sakkas E Mariethoz JC St John 1999 Abnormal sperm paremeters in humans are indicative of an abortive apoptotic mechanism linked to the Fas-mediated pathway Exp Cell Res. 251 2 350 5 10.1006/excr.1999.4586 1:CAS:528: DyaK1MXlsFyhsrk%3D 10471320 (Pubitemid 29431872)
28. W Gorczyca F Traganos H Jesionowska Z Darzynkiewicz 1993 Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: analogy to apoptosis of somatic cells Exp Cell Res. 207 202 5 10.1006/excr.1993.1182 1:CAS:528:DyaK3sXmtVWit7s%3D 8391465 (Pubitemid 23192183)
29. A Riccioli L Salvati A D'Alessio D Starace C Giampietri P De Cesaris, et al. 2003 The Fas system in the seminiferous epithelium and its possible extra-testicular role Andrologia. 35 1 64 70 10.1046/j.1439-0272.2003.00538.x 1:CAS:528:DC%2BD3sXislWit7s%3D 12558530 (Pubitemid 36250105)
30. SM Wykes D Miller SA Krawetz 2000 Mammalian spermatozoal mRNAs: tools for the functional analysis of male gametes J Submicrosc Cytol Pathol. 32 77 81 1:STN:280:DC%2BD3cvptlOkug%3D%3D 10877105
31. D Miller 2000 Analysis and significance of messenger RNA in human ejaculated spermatozoa Mol Reprod Dev. 56 259 64 10.1002/(SICI)1098-2795(200006) 56:2+<259::AID-MRD10>3.0.CO;2-R 1:CAS:528:DC%2BD3cXjtFyrtrk%3D 10824980
32. Y Zhao C Yao Z Wang Y Zhou Y Wang L Liu, et al. 2006 Characterization and quantification of mRNA transcripts in ejaculated spermatozoa of fertile men by serial analysis of gene expression Hum Reprod. 21 6 1583 90 10.1093/humrep/ del027 1:CAS:528:DC%2BD28XntF2gu70%3D 16501037 (Pubitemid 44445040)
33. S Lambard I Galeraud-Denis G Martin R Levy A Chocat S Carreau 2004 Analysis and significance of mRNA in human ejaculated sperm from normozoospermic donors: relationship to sperm motility and capacitation Mol Hum Reprod. 10 7 535 41 10.1093/molehr/gah064 1:CAS:528:DC%2BD2cXltVWnsr8%3D 15100385 (Pubitemid 39136810)
34. T Suda T Takahashi P Goldstein S Nagata 1993 Molecular cloning and expression of the FasL, a novel member of the tumor necrosis factor family Cell. 75 1169 78 10.1016/0092-8674(93)90326-L 1:CAS:528:DyaK2cXhtlWrurY%3D 7505205 (Pubitemid 24006113)
35. T Suda T Okazaki Y Naito T Yokota N Arai S Ozaki, et al. 1995 Expression of the Fas ligand in cells of T cell lineage J Immunol. 154 3806 13 1:CAS:528:DyaK2MXkvFOrtL4%3D 7706720
36. L Dubin RD Amelar 1970 Varicocele size and results of varicocelectomy in selected subfertile men with varicocele Fertil Steril. 21 606 9 1:STN:280:DyaE3c3ltFWqsA%3D%3D 5433164
37. WHO-World Health Organization. Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed. New York: Cambridge University Press; 1999.
38. JI Gorelick M Goldstein 1993 Loss of fertility in men with varicocele Fertil Steril. 59 613 6 1:STN:280:DyaK3s3gvFCitA%3D%3D 8458466
39. MA Witt LI Lipshultz 1993 Varicocele: a progressive or static lesion? Urology. 42 541 3 10.1016/0090-4295(93)90268-F 1:STN:280:DyaK2c%2FlsVynsg%3D%3D 8236597 (Pubitemid 23347268)
40. JS Brown L Dubin RS Hotchkiss 1967 The varicocele as related to fertility Fertil Steril. 18 46 56 1:STN:280:DyaF2s%2FovFOjsw%3D%3D 6017723
41. Practice Committee of the American Society for Reproductive Medicine 2006 Report on varicocele and infertility Fertil Steril. 86 5 Suppl S93 5
42. A Barqawi A Caruso RB Meacham 2004 Experimental varicocele induces testicular germ cell apoptosis in the rat J Urol. 171 501 3 10.1097/01.ju. 0000088775.69010.61 14665963 (Pubitemid 37549219)
43. H Walczak PH Krammer 2000 The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems Exp Cell Res. 256 58 66 10.1006/excr.2000.4840 1:CAS:528:DC%2BD3cXitVajsb4%3D 10739652 (Pubitemid 30211167)
44. A D'Alessio A Riccioli P Lauretti F Padula B Muciaccia P De Cesaris, et al. 2001 Testicular FasL is expressed by sperm cells Proc Natl Acad Sci USA. 98 6 3316 21 10.1073/pnas.051566098 11248076 (Pubitemid 32220843)
45. N Itoh S Yonehara A Ishii M Yonehara S Mizushima M Sameshima, et al. 1991 The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis Cell. 66 233 43 10.1016/0092-8674(91)90614-5 1:CAS:528:DyaK38XksVWls7Y%3D 1713127
46. A Oehm I Behrmann W Falk M Pawlita G Maier C Klas, et al. 1992 Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the fas antigen J Biol Chem. 267 10709 15 1:CAS:528: DyaK3sXhvV2ntLg%3D 1375228
47. S Nagata P Golstein 1995 The Fas death factor Science. 267 1449 56 10.1126/science.7533326 1:CAS:528:DyaK2MXktlClt7w%3D 7533326
48. PJ Barr LD Tomei 1994 Apoptosis and its role in human disease Biotechnology. 12 487 93 10.1038/nbt0594-487 1:STN:280:DyaK2c3jsFaisQ%3D%3D 7764707 (Pubitemid 24145176)
49. HM Shen J Dai SE Chia A Lim CN Ong 2002 Detection of apoptotic alterations in sperm in subfertile patients and their correlations with sperm quality Hum Reprod. 17 1266 73 10.1093/humrep/17.5.1266 11980750
50. U Paasch A Agarwal AK Gupta RK Sharma S Grunewald AJ Thomas Jr, et al. 2003 Apoptosis signal transduction and the maturity status of human spermatozoa Ann N Y Acad Sci. 1010 486 8 10.1196/annals.1299.088 15033775 (Pubitemid 38265030)
51. GC Ostermeier DJ Dix D Miller P Khatri SA Krawetz 2002 Spermatozoal RNA profiles of normal fertile men Lancet. 360 772 7 10.1016/S0140-6736(02)09899-9 1:CAS:528:DC%2BD38Xmsl2nsLg%3D 12241836 (Pubitemid 35247708)
52. RJ Kaufman 2004 Regulation of mRNA translation by protein folding in the endoplasmic reticulum Trends Biochem Sci. 29 3 152 8 10.1016/j.tibs.2004.01.004 1:CAS:528:DC%2BD2cXhslCjt7k%3D 15003273 (Pubitemid 38314861)
53. BN Naftulin SJ Samuels WJ Hellstrom, et al. 1991 Semen quality in varicocele patients is characterized by tapered sperm cells Fertil Steril. 56 149 51 1:STN:280:DyaK3M3ptlegtQ%3D%3D 2065797
54. JS Brown 1976 Varicocelectomy in the subfertile male: a ten-year experience with 295 cases Fertil Steril. 27 1046 53 1:STN:280: DyaE2s%2FgtlOltg%3D%3D 964396
55. LI Lipshultz JN Corriere Jr 1977 Progressive testicular atrophy in the varicocele patient J Urol. 117 175 6 1:STN:280:DyaE2s%2FpslehtQ%3D%3D 833961
56. J Zargooshi 2007 Sperm count and sperm motility in incidental high-grade varicocele Fertil Steril. 88 5 1470 3 10.1016/j.fertnstert.2007.01.016 17451695 (Pubitemid 350030082)
57. RP Bertolla AP Cedenho PA Hassun Filho SB Lima V Ortiz M Srougi 2006 Sperm DNA fragmentation in adolescents with varicocele Fertil Steril. 85 3 625 8 10.1016/j.fertnstert.2005.08.032 1:CAS:528:DC%2BD28XjsVChsrY%3D 16500329 (Pubitemid 43261553)
58. D Miller GC Ostermeier SA Krawetz 2005 The controversy, potential and roles of spermatozoal RNA Trends Mol Med. 11 156 63 10.1016/j.molmed.2005.02.006 1:CAS:528:DC%2BD2MXjtVylsLc%3D 15823753
59. D Miller PZ Tang C Skinner R Lilford 1994 Differential RNA fingerprinting as a tool in the analysis of spermatozoal gene expression Hum Reprod. 9 864 9 1:CAS:528:DyaK2MXivVOjug%3D%3D 7929733
60. S Perticarari G Ricci R Boscolo M De Santis G Pagnini M Martinelli, et al. 2008 Fas receptor is not on ejaculated human sperm Hum Reprod. 23 1271 9 10.1093/humrep/den113 1:CAS:528:DC%2BD1cXmvFSjtLw%3D 18408018 (Pubitemid 351770589)
61. SB Lima MA Cenedeze RP Bertolla PA Hassun Filho S Oehninger AP Cedenho 2006 Expression of the HSPA2 gene in ejaculated spermatozoa from adolescents with and without varicocele Fertil Steril. 86 6 1659 63 10.1016/j.fertnstert. 2006.05.030 1:CAS:528:DC%2BD2sXkt1aksg%3D%3D 17007855