Induction of angiogenic immediate early genes by activation of FP prostanoid receptors in cultured human ciliary smooth muscle cells

Current Eye Research

Volumn 35, Issue 5, 2010, Pages 408-418

  Hutchinson, Anthony J ^a   Coons, Serena C ^b   Chou, Chih Ling ^a   Xu, Wei ^a   Stamer, W Daniel ^b   Woodward, David F ^c   Regan, John W ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c ALLERGAN INC   (United States)

Author keywords

Ciliary muscle; CTGF; EGR 1; FP prostanoid receptor; HIF 1 ; Human eye

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CONNECTIVE TISSUE GROWTH FACTOR; EARLY GROWTH RESPONSE FACTOR 1; HYPOXIA INDUCIBLE FACTOR; LUCIFERASE; MESSENGER RNA; PROSTAGLANDIN F2 ALPHA; PROSTANOID RECEPTOR;

ANGIOGENESIS; ARTICLE; CELL CULTURE; CILIARY BODY; CILIARY SMOOTH MUSCLE CELL; CONTROLLED STUDY; FETUS; GENE INDUCTION; HUMAN; HUMAN CELL; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; REPORTER GENE; SMOOTH MUSCLE FIBER; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ACTINS; BLOTTING, WESTERN; CELLS, CULTURED; CILIARY BODY; CONNECTIVE TISSUE GROWTH FACTOR; DINOPROST; EARLY GROWTH RESPONSE PROTEIN 1; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; GENES, IMMEDIATE-EARLY; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INOSITOL PHOSPHATES; MUSCLE, SMOOTH; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTORS, PROSTAGLANDIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 77952235066     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713680903581021     Document Type: Article

References (40)

1. Toris CB, Gabelt BT, Kaufman PL. Update on the mechanism of action of topical prostaglandins for intraocular pressure reduction. Surv Ophthalmol. 2008;53:S107-S120.
2. Powells WS, Hammarström S, Samuelsson B. Prostaglandin F2? receptor in ovine corpora lutea. Eur J Biochem. 1974;41:103-107.
3. Powells WS, Hammarström S, Samuelsson B. Occurrence and properties of a prostaglandin F2? receptor in bovine corpora lutea. Eur J Biochem. 1975;56:73-77.
4. Sugimoto Y, Hasumoto K, Namba T, et al. Cloning and expression of a cDNA for mouse prostaglandin F receptor. J Biol Chem. 1994;269:1356-1360. (Pubitemid 24032530)
5. Sakamoto K, Ezashi T, Miwa K, et al. Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor. J Biol Chem. 1994;269:3881-3886.
6. Graves PE, Pierce KL, Bailey TJ, et al. Cloning of a receptor for prostaglandin F2 alpha from the ovine corpus luteum. Endocrinology. 1995;136:3430-3436.
7. Abramovitz M, Boie Y, Nguyen T, et al. Cloning and expression of a cDNA for the human prostanoid FP receptor. J Biol Chem. 1994;269:2632-2636. (Pubitemid 24235760)
8. Pierce KL, Bailey TJ, Hoyer PB, et al. Cloning of a carboxylterminal isoform of the prostanoid FP receptor. J Biol Chem. 1997;272:883-887.
9. Liang Y, Woodward DF, Guzman VM, et al. Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes. Br J Pharmacol. 2008;154:1079-1093.
10. Pierce KL, Fujino H, Srinivasan D, et al. Activation of FP prostanoid receptor isoforms leads to Rho-mediated changes in cell morphology and in the cell cytoskeleton. J Biol Chem. 1999;274:35944-35949.
11. Fujino H, Regan JW. FP prostanoid receptor activation of a T-cell factor/β-catenin signaling pathway. J Biol Chem. 2001;276:12489-12492.
12. Xu W, Chou CL, Sun H, et al. FP prostanoid receptormediated induction of the expression of early growth response factor-1 by activation of a Ras/Raf/mitogenactivated protein kinase signaling cascade. Mol Pharmacol. 2008;73:111-118.
13. Xu W, Chou CL, Israel DD, et al. PGF2α stimulates FP prostanoid receptor mediated crosstalk between Ras/Raf signaling and Tcf transcriptional activation. Biochem Biophys Res Commun. 2009; doi:10.1016/j.bbrc.2009.02.102.
14. Crawford K, Kaufman PL. Pilocarpine antagonizes prostaglandin F2α-induced ocular hypotension in monkeys: Evidence for enhancement of uveoscleral outflow by prostaglandin F2?. Invest Ophthalmol Vis Sci. 1987;105: 1112-1116.
15. Nilsson SFE, Samuelsson M, Bill A, et al. Increased uveoscleral outflow as a possible mechanism of ocular hypotension caused by prostaglandin F2α-1-isopropylester in the cynomolgus monkey. Exp Eye Res. 1989;48:707-716.
16. Alm A, Nilsson SFE. Uveoscleral outflow-A review. Exp Eye Res. 2009;88:760-768.
17. Weinreb RN, Toris CB, Gabelt BT, et al. Effects of prostaglandins on the aqueous humor outflow pathways. Surv Ophthalmol. 2002;47:S53-S64.
18. Lütjen-Drecoll E, Tamm E. Morphological study of the anterior segment of cynomolgus monkey eyes following treatment with prostaglandin F2α. Exp Eye Res. 1988;47:761-769.
19. Lindsey JD, Kashiwagi K, Kashiwagi F, et al. Prostaglandins alter extracellular matrix adjacent to human ciliary muscle cells in vitro. Invest Ophthalmol Vis Sci. 1997;38: 2214-2223. (Pubitemid 27446938)
20. Lindsey JD, Kashiwagi K, Kashiwagi F, et al. Prostaglandin action on ciliary smooth muscle extracellular matrix metabolism: Implications for uveoscleral outflow. Surv Ophthalmol. 1997;41:S53-S59.
21. Richter M, Krauss AH-P, Woodward DF, et al. Morphological changes in the anterior eye segment after long-term treatment with different receptor-selective prostaglandin agonists and a prostamide. Invest Ophthalmol Vis Sci. 2003;44:4419-4426.
22. Weinreb RN, Kashiwagi K, Kashiwagi F, et al. Prostaglandins increase matrix metalloproteinase release from human ciliary smooth muscle cells. Invest Ophthalmol Vis Sci. 1997;38:2772-2780. (Pubitemid 28009399)
23. Weinreb RD, Lindsey JD. Metalloproteinase gene transcription in human ciliary muscle cells with latanoprost. Invest Ophthalmol Vis Sci. 2002;43:716-722.
24. Husain S, Jafri F, Crosson CE. Acute effects of PGF2α on MMP-2 secretion from human ciliary muscle cells: A PKCand ERK-dependent process. Invest Ophthalmol Vis Sci. 2005;46:1706-1713.
25. Liang Y, Li C, Guzman VM, et al. Comparison of prostaglandin F2α, bimatoprost (prostamide), and butaprost (EP2 agonist) on Cyr61 and connective tissue growth factor gene expression. J Biol Chem. 2003;278:27267-27277.
26. Weinreb RN, Kim D-M, Lindsey JD. Propagation of ciliary smooth muscle cells in vitro and effects of prostaglandin F2α on calcium efflux. Invest Ophthalmol Vis Sci. 1992;33:2679-2686.
27. Fujino H, Srinivasan D, Pierce KL, et al. Differential regulation of prostaglandin F2α receptor isoforms by protein kinase C. Mol Pharmacol. 2000;57:353-358.
28. Welsh SJ, Bellamy WT, Briehl MM, et al. The redox protein thioredoxin-1 (Trx-1) increases hypoxia inducible factor 1α protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis. Cancer Res. 2002;62:5089-5095.
29. Griffin BW, Klimko P, Crider JY, et al. AL-8810: A novel Prostaglandin F2α analog with selective antagonist effects at the prostaglandin F2α (FP) receptor. J Pharmacol Exp Ther. 1999;290:1278-1284.
30. Mukhopadhyay P, Geoghegan TE, Patil RV, et al. Detection of EP2, EP4, and FP receptors in human ciliary epithelial and ciliary muscle cells. Biochem Pharmacol. 1997;53:1249-1255.
31. Schlötzer-Schrerhardt U, Zenkel M, Nüsing RM. Expression and localization of FP and EP prostanoid receptor subtypes in human ocular tissues. Invest Ophthalmol Vis Sci. 2002;43:1475-1487.
32. Sharif NA, Crider JY, Husain S, et al. Human ciliary muscle cell responses to FP-class prostaglandin analogs: Phosphoinositide hydrolysis, intracellular Ca2+ mobilization and MAP kinase activation. J Ocul Pharmacol Ther. 2003;19: 437-455.
33. Braddock M. The transcription factor Egr-1: A potential drug in wound healing and tissue repair. Ann Med. 2001;33: 313-318.
34. Ke Q, Costa M. Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol. 2006;70:1469-1480.
35. Liu L, Clipstone NA. Prostaglandin F2α induces the normoxic activation of the hypoxia-inducible factor-1 transcription factor in differentiating 3T3-L1 preadipocytes: Potential role in the regulation of adipogenesis. J Cell Bio. 2008;105:89-98.
36. Kaluz S, Kaluzova M, Stanbridge EJ. Regulation of gene expression by hypoxia: Integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element. Clin Chim Acta. 2008;395:6-13.
37. Moussad EA, Brigstock DR. Connective tissue growth factor: What's in a name? Mol Genet Metab. 2000;71: 276-292.
38. Perbal, B. CCN proteins: Multifunctional signaling regulators. Lancet. 2004;263:62-64.
39. Fong, GH. Regulation of angiogenesis by oxygen sensing mechanisms. J Mol Med. 2009;87:549-560.
40. Higgins DF, Biju MP, Akai Y, et al. Hypoxic induction of CTGF is directly mediated by Hif-1. Am J Physiol Renal Physiol. 2004;287:F1223-F1232.