Electrophysiological and neurochemical characterization of 7-nitroindazole and molsidomine acute and sub-chronic administration effects in the dopaminergic nigrostrial system in rats

Journal of Neural Transmission, Supplementa

Volumn , Issue 73, 2009, Pages 173-182

  Di Matteo, Vincenzo ^a   Pierucci, Massimo ^a   Benigno, Arcangelo ^b   Orbán, Gergely ^b   Crescimanno, Giuseppe ^b   Esposito, Ennio ^a   Di Giovanni, Giuseppe ^b  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

Cells per track; Dopamine; Extracellular recording; HPLC; Nitric oxide; Parkinson's disease

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 7 NITROINDAZOLE; DOPAMINE; MOLSIDOMINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; 7-NITROINDAZOLE; ENZYME INHIBITOR; INDAZOLE DERIVATIVE; NITRIC OXIDE DONOR;

ANIMAL CELL; ARTICLE; BASAL GANGLION; CELL POPULATION; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DOPAMINERGIC SYSTEM; EX VIVO STUDY; HUMAN; IN VIVO STUDY; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEUROCHEMISTRY; NEUROTRANSMISSION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA; ACTION POTENTIAL; ANIMAL; CYTOLOGY; DRUG ADMINISTRATION; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; METABOLISM; METHODOLOGY; NERVE CELL; NERVE TRACT; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

3,4-DIHYDROXYPHENYLACETIC ACID; ACTION POTENTIALS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORPUS STRIATUM; DOPAMINE; DRUG ADMINISTRATION SCHEDULE; ENZYME INHIBITORS; INDAZOLES; MALE; MOLSIDOMINE; NEURAL PATHWAYS; NEURONS; NITRIC OXIDE DONORS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA;

EID: 77952220763     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-211-92660-4-14     Document Type: Article

References (66)

1. Bian K, Murad F (2003) Nitric oxide (NO)-biogeneration, regulation, and relevance to human diseases. Front Biosci 8:264-278
2. Bishnoi M, Chopra K, Kulkarni SK (2009) Co-administration of nitric oxide (NO) donors prevents haloperidol-induced orofacial dyskinesia, oxidative damage and change in striatal dopamine levels. Pharmacol Biochem Behav 91:423-429
3. Boger RH, Bode-Boger SM, Gerecke U, Frolich JC (1994) Long-term administration of L-arginine, L-NAME and the exogenous NO donor molsidomine modulates urinary nitrate and cGMP excretion in rats. Cardiovasc Res 28:494-499
4. Boireau A, Dubedat P, Bordier F, Imperato A, Moussaoui S (2000) The protective effect of riluzole in the MPTP model of Parkinson's disease in mice is not due to a decrease in MPP (+) accumulation. Neuropharmacology 39:1016-1020
5. Bredt DS, Hwang PM, Snyder SH (1990) Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347(6295):768-770
6. Bunney BS, Walters JR, Roth RH, Aghajanian GK (1973) Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity. J Pharmacol Exp Ther 185(3):560-571
7. Büyükuysal RL (1997) Effect of nitric oxide donors on endogenous dopamine release from striatal slices. I. Requirement of antioxidants in the medium. Fundam Clin Pharmacol 11:519-527
8. Castagnoli K, Palmer S, Anderson A, Bueters T, Castagnoli N Jr (1997) The neuronal nitric oxide synthase inhibitor 7-nitroindazole also inhibits the monoamine oxidase-B-catalyzed oxidation of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. Chem Res Toxicol 10:364-368
9. Cox BA, Johnson SW (1998) Nitric oxide facilitates N-methyl-D-aspartate- induced burst firing in dopamine neurons from rat midbrain slices. Neurosci Lett 255(3):131-134
10. Del Bel EA, Guimarães FS (2000) Sub-chronic inhibition of nitricoxide synthesis modifies haloperidol-induced catalepsy and the number of NADPH-diaphorase neurons in mice. Psychopharmacology 147:356-361
11. Del Bel EA, da Silva CA, Guimarães FS (1998) Catalepsy induced by nitric oxide synthase inhibitors. Gen Pharmacol 30:245-248
12. Del Bel EA, Souza AS, Guimarães FS, da-Silva CA, Nucci-da-Silva LP (2002) Motor effects of acute and chronic inhibition of nitric oxide synthesis in mice. Psychopharmacology 161:32-37
13. Del Bel EA, da Silva CA, Guimarães FS, Bermudez-Echeverry M (2004) Catalepsy induced by intra-striatal administration of nitric oxide synthase inhibitors in rats. Eur J Pharmacol 485:175-181
14. Del Bel EA, Guimarães FS, Bermudez-Echeverry M, Gomes MZ, Schiaveto-de-souza A, Padovan-Neto FE, Tumas V, Barion-Cavalcanti AP, Lazzarini M, Nucci-da-Silva LP, de Paula-Souza D (2005) Role of nitric oxide on motor behaviour. Cell Mol Neurobiol 25:371-392
15. Del Bel E, Bermúdez-Echeverry M, Salum C, Raisman-Vozari R (2007) Nitric oxide system and basal ganglia physiopathology. In: Di Giovanni G (ed) The basal ganglia pathophysiology: recent advances. Transworld Research Network, Kerala, India
16. Del Bel E, Guimarães F, Joca S, Echeverry M, Ferreira F (2008) Tolerance to the cataleptic effect that follows repeated nitric oxide synthase inhibition may be related to functional enzymatic recovery. J Psychopharmacol published on October 6, 2008 as doi:10.1177/0269881108097717
17. Desvignes C, Bert L, Vinet L, Denoroy L, Renaud B, Lambás- Señas L (1999) Evidence that the neuronal nitric oxide synthase inhibitor 7-nitroindazole inhibits monoamine oxidase in the rat: in vivo effects on extracellular striatal dopamine and 3, 4-dihydroxyphenylacetic acid. Neurosci Lett 264 (1-3): 5-8
18. Di Giovanni G (2007) The Basal Ganglia Pathophysiology: Recent Advances. Transworld Research Network, Kerala, India
19. Di Giovanni G, Ferraro G, Sardo P, Galati S, Esposito E, La Grutta V (2003) Nitric oxide modulates striatal neuronal activity via soluble guanylyl cyclase: an in vivo microiontophoretic study in rats. Synapse 48(2):100-107
20. Di Giovanni G, Ferraro G, Sardo P, Di Maio R, Carlatti F, La Grutta V (2006) Microiontophoretic evidence that nitric oxide alters spontaneous activity of the substantia nigra pars reticulata neurons in the rat. Acta Physiol 188 (Suppl. 652): P184
21. Di Giovanni G, Shi W-X (2009) Effects of Scopolamine on Dopamine Neurons in the Substantia Nigra: Role of the Pedunculopontine Tegmental Nucleus. Synapse 63(8):673-680
22. Di Matteo V, Benigno A, Pierucci M, Giuliano DA, Crescimanno G, Esposito E, Di Giovanni G (2006) 7-nitroindazole protects striatal dopaminergic neurons against MPP+-induced degeneration: an in vivo microdialysis study. Ann NY Acad Sci 1089:462-471
23. Di Matteo V, Pierucci M, Esposito E, Benigno A, Crescimanno G, Di Giovanni G (2009) Involvement of nitric oxide in 6-OHDA-induced neurodegeneration: An ex vivo study. Ann NY Acad Sci 1155:316-323
24. Egberongbe YI, Gentleman SM, Falkai P, Bogerts B, Polak JM, Roberts GW (1994) The distribution of nitric oxide synthase immunoreactivity in the human brain. Neuroscience 59(3):561-578
25. Esposito E, Di Matteo V, Di Giovanni G (2007) Death in the substantia nigra: a motor tragedy. Expert Rev Neurother 7:7677-7697
26. Eve DJ, Nisbet AP, Hewson KAE, EL DSE, Lees AJ, Marsden CD, Foster OJ (1998) Basal ganglia neuronal nitric oxide synthase mRNA expression in Parkinson's disease. Brain Res Mol Brain Res 63(1):62-71
27. Feifer A, Carrier S (2008) Pharmacotherapy for erectile dysfunction. Expert Opin Investig Drugs 17:679-690
28. Floresco SB, West AR, Ash B, Moore H, Grace AA (2003) Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission. Nat Neurosci 6(9):968-973
29. Galati S, D'angelo V, Scarnati E, Stanzione P, Martorana A, Procopio T, Sancesario G, Stefani A (2008) In vivo electrophysiology of dopamine-denervated striatum: focus on the nitric oxide/cGMP signaling pathway. Synapse 62(6):409-420
30. Garthwaite J, Boulton CL (1995) Nitric oxide signaling in the central nervous system. Annu Rev Physiol 57:683-706
31. Gomes MZ, Raisman-Vozari R, Del Bel EA (2008) A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway. Brain Res 1203:160-169
32. Grace AA, Floresco SB, Goto Y, Lodge DJ (2007) Regulation of firing of dopaminergic neurons and control of goal-directed behaviors. Trends Neurosci 30(5):220-227
33. Guevara-Guzman R, Emson PC, Kendrick KM (1994) Modulation of in vivo striatal transmitter release by nitric oxide and cyclic-GMP. J Neurochem 62:807-810
34. Koylu EO, Kanit L, Taskiran D, Dagci T, Balkan B, Pogun S (2005) Effects of nitric oxide synthase inhibition on spatial discrimination learning and central DA2 and mACh receptors. Pharmacol Biochem Behav 81:32-40
35. Krzaścik P, Kostowski W (1997) Nitric oxide donors antagonize N-nitro-L-arginine and haloperidol catalepsy: potential implication for the treatment of Parkinsonism? Pol J Pharmacol 49(4):263-266
36. Leontovich TA, Mukhina YK, Fedorov AA (2004) Neurons of the basal ganglia of the human brain (striatum and basolateral amygdala) expressing the enzyme NADPH-d. Neurosci Behav Physiol 34(3):277-286
37. Liu X, Buffington JA, Tjalkens RB (2005) NF-kappaB-dependent production of nitric oxide by astrocytes mediates apoptosis in differentiated PC12 neurons following exposure to manganese and cytokines. Brain Res Mol Brain Res 141(1):39-47
38. Low SY (2005) Application of pharmaceuticals to nitric oxide. Mol Aspects Med 26 (1-2): 97-138
39. Maccario M, Oleandri SE, Procopio M, Grottoli S, Avogadri E, Camanni F (1997) Comparisons among the effects of arginine, a nitric oxide precursor, isosorbide dinitrate and molsidomine, two nitric oxide donors on hormonal secretions and blood pressure in man. J Endocrinol Invest 20:488-492
40. Marras R, Martins AP, Del Bel EA, Guimarães FS (1995) L-NOARG, an inhibitor of nitric oxide synthase induces catalepsy in mice. NeuroReport 7:158-160
41. Moore PK, Babbedge RC, Wallace P, Gaffen ZA, Hart SL (1993) 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol 108:296-297
42. Nisbet AP, Foster OJ, Kingsbury A, Lees AJ, Marsden CD (1994) Nitric oxide synthase mRNA expression in human subthalamic nucleus, striatum and globus pallidus: implications for basal ganglia function. Brain Res Mol Brain Res 22 (1-4): 329-332
43. Nitz R, Fiedler V (1987) Molsidomine: alternative approaches to treat myocardial ischemia. Pharmacotherapy 7:28-37
44. Ondracek JM, Dec. A, Hoque KE, Lim SA, Rasouli G, Indorkar RP, Linardakis J, Klika B, Mukherji SJ, Burnazi M, Threlfell S, Sammut S, West AR (2008) Feed-forward excitation of striatal neuron activity by frontal cortical activation of nitric oxide signaling in vivo. Eur J Neurosci 27(7):1739-1754
45. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd edn. Academic, New York
46. Rigamonti AE, Cella SG, Cavallera GM, Deghenghi R, Locatelli V, Pitsikas N, Muller EE (2001) Contrasting effects of nitric oxide on food intake and GH secretion stimulated by a GH-releasing peptide. Eur J Endocrinol 144:155-162
47. Rosenkranz B, Winkelmann BR, Parnham MJ (1996) Clinical pharmacokinetics of molsidomine. Clin Pharmacokinet 30:372-384
48. Sammut S, Dec. A, Mitchell D, Linardakis J, Ortiguela M, West AR (2006) Phasic dopaminergic transmission increases NO efflux in the rat dorsal striatum via a neuronal NOS and a dopamine D (1/5) receptor-dependent mechanism. Neuropsychopharmacology 31(3):493-505
49. Sammut S, Bray KE, West AR (2007) Dopamine D2 receptor-dependent modulation of striatal NO synthase activity. Psychopharmacology (Berl) 191(3):793-803
50. Sardo P, Ferraro G, Di Giovanni G, Galati S, La Grutta V (2002) Inhibition of nitric oxide synthase influences the activity of striatal neurons in the rat. Neurosci Lett 325(3):179-182
51. Sardo P, Ferraro G, Di Giovanni G, La Grutta V (2003) Nitric oxideinduced inhibition on striatal cells and excitation on globus pallidus neurons: a microiontophoretic study in the rat. Neurosci Lett 343(2):101-104
52. Sardo P, Carletti F, D'Agostino S, Rizzo V, Ferraro G (2006) Effects of nitric oxide-active drugs on the discharge of subthalamic neurons: microiontophoretic evidence in the rat. Eur J Neurosci 24(7):1995-2002
53. Schilström B, Mameli-Engvall M, Rawal N, Grillner P, Jardemark K, Svensson TH (2004) Nitric oxide is involved in nicotine-induced burst firing of rat ventral tegmental area dopamine neurons. Neuroscience 125:957-964
54. Shi WX, Smith PL, Pun CL, Millet B, Bunney BS (1997) D1-D2 interaction in feedback control of midbrain dopamine neurons. J Neurosci 17(20):7988-7994
55. Shim SS, Bunney BS, Shi WX (1996) Effects of lesions in the medial prefrontal cortex on the activity of midbrain dopamine neurons. Neuropsychopharmacology 15(5):437-441
56. Silva MT, Rose S, Hindmarsh JG, Aislaitner G, Gorrod JW, Moore PK, Jenner P, Marsden CD (1995) Increased striatal dopamine efflux in vivo following inhibition of cerebral nitric oxide synthase by the novel monosodium salt of 7-nitro indazole. Br J Pharmacol 114(2):257-258
57. Silva MT, Rose S, Hindmarsh JG, Jenner P (2003) Inhibition of neuronal nitric oxide synthase increases dopamine efflux from rat striatum. J Neural Transm 110(4):353-362
58. Simola N, Morelli M, Carta AR (2007) The 6-hydroxydopamine model of Parkinson's disease. Neurotox Res 11:151-167
59. Southan GJ, Szabo C (1996) Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem Pharmacol 51:383-394
60. Sugaya K, McKinney M (1994) Nitric oxide synthase gene expression in cholinergic neurons in the rat brain examined by combined immunocytochemistry and in situ hybridization histochemistry. Mol Brain Res 23:111-125
61. Thatcher GR, Bennett BM, Reynolds JN (2006) NO chimeras as therapeutic agents in Alzheimer's disease. Curr Alzheimer Res 3:237-245
62. Thomas B, Saravanan KS, Mohanakumar KP (2008) Invitro and in vivo evidences that antioxidant action contributes to the neuroprotective effects of the neuronal nitric oxide synthase and monoamine oxidase-B inhibitor, 7-nitroindazole. Neurochem Int 52:990-1001
63. Trabace L, Kendrick KM (2000) Nitric oxide can differentially modulate striatal neurotransmitter concentrations via soluble guanylate cyclase and peroxynitrite formation. J Neurochem 75(4):1664-1674
64. Vincent SR, Kimura H (1992) Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 46(4):755-784
65. West AR, Grace AA (2000) Striatal nitric oxide signaling regulates the neuronal activity of midbrain dopamine neurons in vivo. J Neurophysiol 83(4):1796-1808
66. West AR, Galloway MP, Grace AA (2002) Regulation of striatal dopamine neurotransmission by nitric oxide: effector pathways and signaling mechanisms. Synapse 44(4):227-245