Expression of regulatory T cells and Foxp3 gene in peripheral blood of children with aplastic anemia

Chinese Journal of Contemporary Pediatrics

Volumn 12, Issue 4, 2010, Pages 241-243

  Wang, Xi Ge ^a   Wang, Xiao Ge ^a   Luan, Bin ^a   Hu, Ji Ting ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Aplastic anemia; Child; Flow cytometry; Foxp3; Regulatory T cell

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

APLASTIC ANEMIA; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; PATHOGENESIS; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ANEMIA, APLASTIC; CHILD; CHILD, PRESCHOOL; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MALE; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY;

EID: 77952218874     PISSN: 10088830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Brodsky RA, Jones RJ. Aplastic anemia[J]. Lancet, 2005, 365 (9471):1647-1656.
2. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologie self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases[J]. J Immunol, 1995, 155(3):1151-1164.
3. Costantino CM, Baecher-Allan CM, Hafler DA. Human regulatory T cells and autoimmunity[J]. Eur Immunol, 2008, 38(4):921-924.
4. + reguatory T cells:thymus or periphery [J]. J Clin Invest, 2003, 112(9):1310-1322. (Pubitemid 38057683)
5. + T regulatory cells in acquired aplastie anemia[J]. Blood, 2007, 110(5):1603-1606.
6. Chen J, Ellison FM, Eckhaus MA, Smith AL, Keyvanfar K, Calado RT, et al. Minor antigen H60-mediated aplastic anemia is ameliorated by immunosuppression and the infusion of regulatory T cells[J]. J Immunol, 2007, 178(7):4159-4168. (Pubitemid 46492366)
7. Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM. Human CD4 + regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells[J]. J Immunol Methods, 2007, 319(1-2):41-52. (Pubitemid 46110995)
8. Fontenot JD, Rudensky AY. A well adapted regulatory contriveance: regulatory T cell development and the forkhead family transcription factor Foxp3 [J]. NAT Immunol, 2005, 6(4):331-337.