Lung function testing in preschool-aged children with cystic fibrosis in the clinical setting

Pediatric Pulmonology

Volumn 45, Issue 5, 2010, Pages 419-433

  Gangell, Catherine L ^a   Hall, Graham L ^a,b   Stick, Stephen M ^a,b   Sly, Peter D ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

Author keywords

Cystic fibrosis; Infection; Inflammation; Lung structure; Preschool children; Pulmonary function

Indexed keywords

BRONCHODILATING AGENT;

AIRWAY RESISTANCE; BREATH ANALYSIS; BRONCHODILATATION; CHILD; CHILDHOOD DISEASE; CLINICAL ASSESSMENT; CYSTIC FIBROSIS; FEASIBILITY STUDY; FORCED OSCILLATION TECHNIQUE; HUMAN; INTERRUPTER TECHNIQUE; LUNG FUNCTION; LUNG FUNCTION TEST; LUNG INFECTION; LUNG LAVAGE; MULTIPLE BREATH WASHOUT; OSCILLOMETRY; PLETHYSMOGRAPHY; PNEUMONIA; PRESCHOOL CHILD; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RELIABILITY; REVIEW; SPIROMETRY; TECHNIQUE; TREATMENT RESPONSE;

BRONCHODILATOR AGENTS; CHILD, PRESCHOOL; CYSTIC FIBROSIS; HUMANS; LUNG; OSCILLOMETRY; PLETHYSMOGRAPHY; RESPIRATORY FUNCTION TESTS; SPIROMETRY; TIDAL VOLUME;

EID: 77952204277     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.21192     Document Type: Review

References (127)

1. Beydon N, Davis SD, Lombardi E, Allen JL, Arets HGM, Aurora P, Bisgaard H, Davis GM, Ducharme FM, Eigen H, Gappa M, Gauitier C, Gustafsson PM, Hall GL, Hantos Z, Healy MJR, Jones MH, Klug B, Lodrup Cadsen KC, McKenzie SA, Marchal F, Mayer OH, Merkus PJFM, Morris MG, Oostveen E, Pillow JJ, Seddon PC, Silverman M, Sly PP, Stocks J, Tepper RS, Vilozni D, Wilson NM. An Official American Thoracic Society/Europan Respiratory Society Statement: pulmonary function testing in preschool children. Am J Respir Crit Care Med 2007;175:1304-1345.
2. Bisgaard H, Klug B. Lung function measurement in awake young children. Eur Respir J 1995;8:2067-2075.
3. Boccaccino A, Peroni D, Pietrobelli A, Piacentini G, Bodini A, Chatzimichail A, Spinosa B, Boner AL. Assessment of variable obstruction by forced expiratory volume in 1 second, forced oscillometry, and interrupter technique. Allergy Asthma Proc 2007;28:331-335.
4. Brennan S, Hall GL, Horak F, Moeller A, Pitrez PMC, Franzmann A, Turner S, de Klerk N, Franklin P, Winfield KR, Balding E, Stick SM, Sly PD. Correlation of forced oscillation technique in preschool children with cystic fibrosis with pulmonary inflammation. Thorax 2005;60:159-163.
5. Delacourt C, Lorino H, Furhmann C, Herve-Guillot M, Reinert P, Harf A, Housset B. Comparison of the forced oscillation technique and the interrupter technique for assessing airway obstruction and its reversibility in children. Am J Respir Crit Care Med 2001;164:965-972. (Pubitemid 32971642)
6. Delacourt C, Lorino H, Herve-Guillot M, Reinert P, Harf A, Housset B. Use of the forced oscillation technique to assess airway obstruction and reversibility in children. Am J Respir Crit Care Med 2000;161:730-736. (Pubitemid 30171724)
7. Dencker M, Malmberg L, Valind S, Thorsson O, Karlsson M, Pelkonen A, Pohjanpalo A, Haahtela T, Turpeinen M, Wollmer P. Reference values for respiratory system impedance by using impulse oscillometry in children aged 2-11 years. Clin Physiol Funct Imaging 2006;26:247-250. (Pubitemid 43905140)
8. Duiverman E, Clement J, van de Woestijne K, Neijens H, van den Bergh A, Kerrebijn K. Forced oscillation technique. Reference values for resistance and reactance over a frequency spectrum of 2-26 Hz in healthy children aged 2.3-12.5 years. Bull Eur Physiopathol Respir 1985;21:171-178.
9. Duiverman EJ, Den Boer JA, Roorda RJ, Rooyackers CMHM, Valstar M, Kerrebijn KF. Lung function and bronchial responsiveness measured by forced oscillometry after broncho-pulmonary dysplasia. Arch Dis Child 1988;63:727-732.
10. Frei J, Jutla J, Kramer G, Hatzakis G, Ducharme F, Davis G. Impulse oscillometry: reference values in children 100 to 150 cm in height and 3 to 10 years of age. Chest 2005;128: 1266-1273. (Pubitemid 41324406)
11. Hall GL, Sly PD, Fukushima T, Kusel M, Franklin P, Horak F, Jr., Paterson H, Gangell C, Stick SM. Respiratory function in healthy young children using forced oscillations. Thorax 2007;62:521-526. (Pubitemid 46910132)
12. Hellinckx J, De Boeck K, Bande-Knops J, van der Poel M, Demedts M. Bronchodilator response in 3-6.5 years old healthy and stable asthmatic children. Eur Respir J 1998;12:438-443. (Pubitemid 28389542)
13. Klug B, Bisgaard H. Measurement of lung function in awake 2- 4-year-old asthmatic children during Methacholine challenge and acute asthma: a comparison of the impulse oscillation technique, the interrupter technique, and transcutaneous measurement of oxygen versus whole-body plethysmography. Pediatr Pulmonol 1996;21:290-300.
14. Klug B, Bisgaard H. Specific airway resistance, interrupter resistance and respiratory impedance in healthy chidren aged 2- 7 years. Pediatr Pulmonol 1998;25:322-331. (Pubitemid 28262172)
15. Klug B, Bisgaard H. Lung function and short-term outcome in young asthmatic children. Eur Respir J 1999;14:1185-1189.
16. Lebecque P, Desmond K, Swartebroeckx Y, Dubois P, Lulling J, Coates A. Measurement of respiratory system resistance by forced oscillation in normal children: a comparison with spirometric values. Pediatr Pulmonol 1991;10:117-122.
17. Lebecque P, Stanescu D. Respiratory resistance by the forced oscillation technique in asthmatic children and cystic fibrosis patients. Eur Respir J 1997;10:891-895. (Pubitemid 27180204)
18. Malmberg L, Mieskonen S, Pelkonen A, Kari A, Sovijarvi A, Turpeinen M. Lung function measured by the oscillometric method in prematurely born children with chronic lung disease. Eur Respir J 2000;16:598-603.
19. Marotta A, Klinnert M, Price M, Larsen G, Liu A. Impulse oscillometry provides an effective measure of lung dysfunction in 4-year-old children at risk of persistent asthma. J Allergy Clin Immunol 2003;112:317-322. (Pubitemid 36981371)
20. Nielsen K, Bisgaard H. Lung function response to cold air challenge in asthmatic and healthy children of 2-5 years of age. Am J Respir Crit Care Med 2000;161:1805-1809. (Pubitemid 30418111)
21. Nielsen K, Bisgaard H. The effect of inhaled budesonide on symptoms, lung function, and cold air and methacholine responsiveness in 2- to 5-year-old asthmatic children. Am J Respir Crit Care Med 2000;162:1500-1506.
22. Nielsen KG, Pressler T, Klug B, Koch C, Bisgaard H. Serial lung function and responsiveness in cystic fibrosis during early childhood. Am J Respir Crit Care Med 2004;169:1209-1216. (Pubitemid 38680398)
23. Ortiz G, Menendez R. The effects of inhaled albuterol and salmeterol in 2- to 5-year-old asthmatic children as measured by impulse oscillometry. J Asthma 2002;39:531-536.
24. Vrijlandt E, Boezen H, Gerritsen J, Stremmelaar E, Duiverman E. Respiratory health in prematurely born preschool children with and without bronchopulmonary dysplasia. J Pediatr 2007; 150:256-261. (Pubitemid 46328970)
25. Beydon N, Amsallem F, Bellet M, Coule M, Chaussain M, Dejean A, Matran R, Wuyan B, Alberti C, Gaultier C. Pre/ postbronchodilator interrupter resistance values in healthy young children. Am J Respir Crit Care Med 2002;165:1388-1394. (Pubitemid 34522942)
26. Beydon N, M'Buila C, Bados A, Peiffer C, Bernard A, Zaccaria I, Denjean A. Interrupter resistance short-term repeatability and bronchodilator response in preschool children. Respir Med 2007;101:2482-2487. (Pubitemid 350000962)
27. Black J, Baxter-Jones AD, Gordon J, Findlay AL, Helms PJ. Assessment of airway function in young children with asthma: comparison of spirometry, interrupter technique, and tidal flow by inductance plethsmography. Pediatr Pulmonol 2004;37:548-553. (Pubitemid 38680122)
28. Bridge P, Ranganathan S, McKenzie S. Measuremnt of airway resistance using the interrupter technique in preschool children in the ambulatory setting. Eur Respir J 1999;13:792-796. (Pubitemid 29234780)
29. Davis P, Doull I, Child F. The interrupter technique to assess airway responsiveness in children with cystic fibrosis. Pediatr Pulmonol 2007;42:23-28. (Pubitemid 46080149)
30. Kannisto S, Vanninen E, Korppi M. Evaluation of the interrupter technique in measuring post-exercise bronchodilator responses in children. Clin Physiol 2000;20:62-68. (Pubitemid 30064040)
31. Kannisto S, Vanninen E, Remes K, Korppi M. Interrupter technique for evaluation of exercise-induced bronchospasm in children. Pediatr Pulmonol 1999;27:203-207. (Pubitemid 29157623)
32. Merkus P, Minjnsbergen J, Hop W, de Jongste J. Interrupter resistance in preschool chlidren. Am J Respir Crit Care Med 2001;163:1350-1355.
33. Nielsen KG, Bisgaard H. Discriminative capacity of bronchodilator response measured with three different lung function techniques in asthmatic and healthy children aged 2 to 5 years. Am J Respir Crit Care Med 2001;164:554-559. (Pubitemid 32801655)
34. Oswald-Mammosser M, Charloux A, Donato L, Albrech C, Speich J, Lampert E, Lonsdorfer J. Interrupter technique versus plethysmography for measurement of respiratory resistance in children with asthma or cystic fibrosis. Pediatr Pulmonol 2000;29:213-220. (Pubitemid 30141799)
35. Oswald-Mammosser M, Llerena C, Speich J, Donata L, Lonsdorfer J. Measurements of respiratory system resistance by the interrupter technique in healthy and asthmatic children. Pediatr Pulmonol 1997;24:78-85. (Pubitemid 27450721)
36. Thomas M, Rafferty G, Blowes R, Peacock J, Marlow N, Calvert S, Milner A, Greenough A. Plethysmograph and interrupter resistance measurements in prematurely born young children. Arch Dis Child 2006;91:F193-F196.
37. Badier M, Guillot C, Dubus J. Bronchial challenge with carbachol in 3-6 year old children: body plethysmography assessments. Pediatr Pulmonol 1999;27:117-123.
38. von Ungern-Sternberg BS, Regli A, Frei FJ, Ritz EM, Hammer J, Schibler A, Erb TO. A deeper level of ketamine anesthesia does not affect functional residual capacity and ventilation distribution in healthy preschool children. Paediatr Anaesth 2007;17:1150-1155.
39. Horsley A, Gustafsson P, Macleod K, Saunders C, Greening A, Porteous D, Davies J, Cunningham S, Alton E, Innes JA. Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults wiht cystic fibrosis. Thorax 2008; 63:135-140.
40. Gustafsson PM, Kallman S, Ljungberg H, Lindblad A. Method for assessment of volume of trapped gas in infants during multiple-breath inert gas washout. Pediatr Pulmonol 2003;35: 42-49. (Pubitemid 36009012)
41. Aurora P, Bush A, Gustafsson P, Oliver C, Wallis C, Price J, Stroobant J, Carr S, Stocks J. Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis. Am J Respir Crit Care Med 2005;171:249-256.
42. Aurora P, Gustafsson P, Bush A, Lindblad A, Oliver C, Wallis CE, Stocks J. Multiple breath inert gas washout as a measure of ventilation distribution in children with cystic fibrosis. Thorax 2004;59:1068-1073.
43. Aurora P, Kozlowska W, Stocks J. Gas mixing efficiency from birth to adulthood measured by multiple-breath washout. Respir Physiol Neurobiol 2005;148:125-139. (Pubitemid 41132754)
44. Gustafsson P, de Jong P, Tiddens H, Lindblad A. Multiple-breath inert gas washout and spirometry vs. structural lung disease in cystic fibrosis. Thorax 2008;63:129-134. (Pubitemid 351236476)
45. Crenesse D, Berlioz M, Bourrier T, Albertini M. Spirometry in children aged 3 to 5 years: reliability of forced expiratory maneuvers. Pediatr Pulmonol 2001;32:56-61.
46. Eigen H, Bieler H, Grant D, Christoph K, Terrill D, Heilman DK, Ambrosius WT, Tepper RS. Spirometric pulmonary function in healthy preschool children. Am J Respir Crit Care Med 2001;163:619-623. (Pubitemid 32230819)
47. Kanengiser S, Dozor AJ. Forced expiratory maneuvers in children aged 3 to 5 years. Pediatr Pulmonol 1994;18:144-149.
48. Marostica PJC, Weist AD, Eigen H, Angelicchio C, Christoph K, Savage J, Grant D, Tepper RS. Spirometry in 3- to 6-year-old children with cystic fibrosis. Am J Respir Crit Care Med 2002;166:67-71. (Pubitemid 34693965)
49. Neve V, Edme J, Devos P, Deschildre A, Thumerelle C, Santos C, Methlin CM, Matran M, Matran R. Spirometry in 3-5 year old children with asthma. Pediatr Pulmonol 2006;41:735-743. (Pubitemid 44157356)
50. Pesant C, Stantschi M, Praud J, Geoffroy M, Niyonsenga T, Vlachos-Mayer H. Spirometric pulmonary function in 3- to 5- year old children. Pediatr Pulmonol 2007;42:263-271. (Pubitemid 46417700)
51. Piccioni P, Borraccino A, Forneris M, Migliore E, Carena C, Bignamini E, Fassio S, Cordola G, Arossa W, Bugiani M. Reference values of forced expiratory volumes and pulmonary flow in 3-6 year children: a cross-sectional study. Respir Res 2007;8:14.
52. Rosenthal M, Bain SH, Cramer D, Helms P, Denison D, Bush A, Warner JO. Lung function in white children aged 4 to 19 years: I-Spirometry. Thorax 1993;48:794-802. (Pubitemid 23244340)
53. Vilozni D, Bentur L, Efrati O, Barak A, Szeinberg A, Shoseyov D, Yahav Y, Augarten A. Exercise challenge test in 3- to 6-year-old asthmatic children. Chest 2007;132:497-503. (Pubitemid 47282382)
54. Beydon N, Amsallem F, Bellet M, Boule M, Chaussain M, Denjean A, Matran R, Pin I, Alberti C, Gaultier C. Pulmonary function tests in preschool children with cystic fibrosis. Am J Respir Crit Care Med 2002;166: 1099-1104. (Pubitemid 35178708)
55. Thamrin C, Gangell CL, Udomittipong K, Kusel MMH, Patterson H, Fukushima T, Schultz A, Hail GL, Stick SM, Sly PD. Assessment of bronchodilator responsiveness in preschool children using forced oscillations. Thorax 2007;62: 813-818. (Pubitemid 47435037)
56. DuBois A, Brody AW, Lewis DH, Burgess BF. Oscillation mechanics of lungs and chest in man. J Appl Physiol 1956;8: 587-594.
57. Landser FJ, Nagels J, Demedts M, Billiet L, van de Woestijne KP. A new method to determine frequency characteristics of the respiratory system. J Appl Physiol 1976;41:101-106.
58. Hellinckx J, Cauberghs M, De Boeck K, Demedts M. Evaluation of impulse oscillation system: comparison with forced oscillation technique and body plethysmography. Eur Respir J 2001;18:564-570. (Pubitemid 32895644)
59. Peslin R, Fredberg J. Oscillation mechanics of the respiratory system. In: Fishman A, editor. Handbook of Physiology. Maryland: American Physiological Society; 1986. pp 145-177
60. Freund F, Roos A, Dodd RB. Expiratory activity of the abdominal muscles in man during general anesthesia. J Appl Physiol 1964;19:694-697.
61. Smith HJ, Reinhold P, Goldman MD. Forced oscillation technique and impulse oscillometry. Eur Respir Mon 2005; 31:72-105.
62. Goldman MD. Clinical application of forced oscillation. Pulm Pharmacol Ther 2001;14:341-350.
63. von Neergaard K, Wirz K. Die messung der stromungwiderstande in den atemwegen des menschen, insbesondere bei asthma und emphysem. Z Klin Med 1926;105:51-52.
64. Beydon N. Interrupter resistance: what's feasible? Paediatr Respir Rev 2006;7:5-7.
65. Bridge P, McKenzie SA. Airway resistance measured by the interrupter technique: expiration or inspiration, mean or median? Eur Respir J 2001;17:495-498. (Pubitemid 32600621)
66. Carter ER, Stecenko AA, Pollock BH, Jaeger MJ. Evaluation of the interrupter technique for the use of assessing airway obstruction in children. Pediatr Pulmonol 1994;17:211-217.
67. Hall GL, Wildhaber JH, Cernelc M, Frey U. Evaluation of the interrupter technique in healthy, unsedated infants. Eur Respir J 2001;18:982-988. (Pubitemid 34092873)
68. Lombardi E, Sly PD, Concutelli G, Novembre E, Veneruso G, Frongia G, Bernardini R, Vierucci A. Reference values of interrupter respiratory resistance in healthy preschool white children. Thorax 2001;56:691-695. (Pubitemid 32831696)
69. Bates JH, Sly PD, Okubo S. General method for describing and extrapolating monotonic transients and its application to respiratory mechanics. Med Biol Eng Comput 1987;25:132-135.
70. Chowienczyk PJ, Lawson CP, Lane S, Johnson R, Wilson N, Silverman M, Cochrane GM. A flow interruption device for measurement of airway resistance. Eur Respir J 1991;4:623-628.
71. Phagoo SB, Wilson NM, Silverman M. Evaluation of the interrupter technique for measuring change in airway resistance in 5-year-old asthmatic children. Pediatr Pulmonol 1995;20: 387-395.
72. DuBois A, Botelho S, Comroe J. A new method for measureing airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease. J Clin Invest 1956;35:327-335.
73. Bisgaard H, Neilsen KG. Plethysmographic measurements of specific airway resistance in young children. Chest 2005;128: 355-362. (Pubitemid 40994495)
74. Goldman MD, Smith HJ, Ulmer WT. Whole-body plethysmography. Eur Respir Mon 2005;31:15-43.
75. Dab I, Alexander F. A simplified approach to the measurement of specific airway resistance. Pediatr Res 1976;10:998-999.
76. Joseph-Bowen J, de Klerk NH, Firth MJ, Kendall GE, Holt PG, Sly PD. Lung function, bronchial responsiveness and asthma in a community cohort of 6 year old children. Am J Respir Crit Care Med 2004;169:850-854. (Pubitemid 38402462)
77. Nystad W, Samuelsen SO, Nafstad P, Edvardsen E, Stensrud T, Jaakkola JJ. Feasibility of measuring lung function in preschool children. Thorax 2002;57:1021-1027. (Pubitemid 35440760)
78. Vilozni D, Barak A, Efrati O, Augarten A, Springer C, Yahav Y, Bentur L. The role of computer games in measuring spirometry in healhty and "asthmatic" preschool children. Chest 2005;128: 1146-1155. (Pubitemid 41324389)
79. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CPM, Gustafsson P, et al. Standardisation of spirometry. Eur Respir J 2005;26: 319-338.
80. Vilozni D, Barker M, Jellouschek H, Heimann G, Blau H. An interactive computer-animated system (SpiroGame) facilitates spirometry in preschool children. Am J Respir Crit Care Med 2001;164:2200-2205. (Pubitemid 34032936)
81. Arets HG, Brackel HJ, van der Ent CK. Forced expiratory manoeuvres in children: do they meet ATS and ERS criteria for spirometry? Eur Respir J 2001;18:655-660.
82. Aurora P, Stocks J, Oliver C, Saunders C, Castle R, Chaziparasidis G, Bush A. Quality control for spirometry in preschool children with and without lung disease. Am J Respir Crit Care Med 2004;169:1152-1159. (Pubitemid 38624796)
83. Zapletal A, Chalupova J. Forced expiratory parameters in healthy preschool children (3-6 years of age). Pediatr Pulmonol 2003;35:200-207. (Pubitemid 36246157)
84. Ducharme FM, Davis M. Measurement of respiratory resistance in the emergency department: feasibility in young children with acute asthma. Chest 1997;111:1519-1525.
85. Ducharme F, Davis G, Ducharme G. Pediatric reference values for respiratory resistance measured by forced oscillation. Chest 1998;113:1322-1328.
86. Malmberg LP, Pelkonen A, Poussa T, Pohjanpalo A, Haahtela T, Turpeinen M. Determinants of respiratory system input impedance and bronchodilator response in healthy Finnish preschool children. Clin Physiol Funct Imaging 2002;22:64-71.
87. Mayer OH, Jawad AF, McDonough J, Allen J. Lung function in 3-5-year-old children with cystic fibrosis. Pediatr Pulmonol 2008;43:1214-1223.
88. Oostveen E, MacLeod D, Lorino H, Farre R, Hantos Z, Desager K, Marchal F. The forced oscillation technique in clinical practice: methodology, recommendations and future developments. Eur Respir J 2003;22:1026-1041.
89. Beelen R, Smit H, van Strien R, Koopman L, Brussee J, Brunekreef B, Gerritsen J, Merkus PJFM. Short and long term variability of the interrupter technique under field and standardised conditions in 3-6 year old children. Thorax 2003;58: 761-764.
90. Chan EY, Bridge PD, Dundas I, Pao CS, Healy MJR, McKenzie SA. Repeatability of airway resistance measurements made using the interrupter technique. Thorax 2003;58:344-347.
91. Hall GL, Gangell C, Fukushima T, Horak F, Patterson HS, Stick SM, Sly PD, Franklin PJ. Application of a shortened inhaled adenosine-5′- monophosphate challenge in young children using the forced oscillation technique. Chest 2009;136:184-189.
92. Klug B, Bisgaard H. Repeatability of methacoline challenges in 2- to 4-year-old children with asthma, using a new technique for quantitative delivery of aerosol. Pediatr Pulmonol 1997;23: 278-286.
93. Corey M, Edwards L, Levison H, Knowles M. Longitudinal analysis of pulmonary function decline in patients with cystic fibrosis. J Pediatr 1997;131:809-814.
94. Farrell PM, Li Z, Kosorok MR, Laxova A, Green CG, Collins J, Lai HC, Makholm LM, Rock MJ, Splaingard ML. Longitudinal evaluation of bronchopulmonary disease in children with cystic fibrosis. Pediatr Pulmonol 2003;36:230-240. (Pubitemid 37055971)
95. Gustafsson P. Peripheral airway involvement in CF and asthma compared by inert gas washout. Pediatr Pulmonol 2007; 42: 168-176.
96. Hellinckx J, De Boeck K, Demedts M. No paradoxical bronchodilator response with forced oscillation technique in children with cystic fibrosis. Chest 1998;113:55-59.
97. Kraemer R, Blum A, Schibler A, Ammann RA, Gallati S. Ventilation inhomogeneities in relation to standard lung function in patients with cystic fibrosis. Am J Respir Crit Care Med 2005;171:371-378.
98. Solymar L, Aronsson PH, Sixt R. The forced oscillation technique in children with respiratory disease. Pediatr Pulmonol 1985;1:256-261.
99. Vilozni D, Bentur L, Efrati O, Minuskin T, Barak A, Szeinberg A, Blau H, Picard E, Kerem E, Yahav Y, et al. Spirometry in early childhood in cystic fibrosis patients. Chest 2007;131:356-361.
100. Gangell CL, Horak F, Jr., Patterson HJ, Sly PD, Stick SM, Hall GL. Respiratory impedance in children with cystic fibrosis using forced oscillations in clinic. Eur Respir J 2007;30:892-897.
101. Terheggen-Lagro S, Arets H, van der Laag J, van der Ent C. Radiological and functional changes over 3 years in young children with cystic fibrosis. Eur Respir J 2007;30:279-285.
102. Dakin CJ, Numa AH, Wang H, Morton JR, Vertzyas CC, Henry RL. Inflammation, infection, and pulmonary function in infants and young children with cystic fibrosis. Am J Respir Crit Care Med 2002;165:904-910.
103. Rosenfeld M, Emerson J, Williams-Warren J, Pepe M, Smith A, Montgomery AB, et al. Defining a pulmonary exacerbation in cystic fibrosis. J Pediatr 2001;139:359-365.
104. Pattishall EN. Longitudinal response of pulmonary function to bronchodilators in cystic fibrosis. Pediatr Pulmonol 1990;9:80-85.
105. Desmond KJ, Demizio DL, Allen PD, MacDonald ND, Coates AL. Effect of salbutamol on gas compression in cystic fibrosis and asthma. Am J Respir Crit Care Med 1994;149:673-677.
106. Landau L, Phelan PD. The variable effect of a bronchodilating agent on pulmonary function in cystic fibrosis. J Pediatr 1973;82:863-868.
107. Zach MS, Oberwaldner B, Forche G, Polgar G. Bronchodilators increase airway instability in cystic fibrosis. Am Rev Respir Dis 1985;131:537-543.
108. Hiatt P, Eigen H, Yu P, Tepper RS. Bronchodilator reponsiveness in infants and young children with cystic fibrosis. Am Rev Respir Dis 1988;137:119-122.
109. Hordvik NL, Konig P, Morris D, Kreutz C, Barbero GJ. A longitudinal study of bronchodilator responsiveness in cystic fibrosis. Am Rev Respir Dis 1985;131:889-893.
110. Lifschitz M, Denning C. Assessment of bronchospasm in patients with cystic fibrosis. Am Rev Respir Dis 1969;99:399-405.
111. Mazurek H, Marchal F, Derelle J, Hatahet R, Moneret-Vautrin D, Monin P. Specificity and sensitivity of respiratory impedance in assessing reversibility of airway obsruction in children. Chest 1995;107:996-1002.
112. Armstrong D, Grimwood K, Carlin J, Carzino R, Olinsky A, Phelan P. Bronchoalveolar lavage or oropharyngeal cultures to identify lower respiratory pathogens in infants with cystic fibrosis. Pediatr Pulmonol 1996;21:267-275.
113. Avital A, Springer C, Bar-Yishay E, Godfrey S. Adenosine, methacholine, and exercise challenges in children with asthma or paediatric chronic obstructive pulmonary disease. Thorax 1995;50:511-516.
114. Rosenfeld M, Emerson J, Accurso F, Armstrong D, Castile R, Grimwood K, Hiatt P, McCoy K, McNamara S, Ramsey B, et al. Diagnostic accuracy of oropharyngeal cultures in infants and young children with cystic fibrosis. Pediatr Pulmonol 1999;28:321-328.
115. Bodini A, D'Orazio C, Peroni D, Corradi M, Folesani G, Baraldi E, Assael B, Boner AL, Piacentini G. Biomarkers of neutrophilic inflammation in exhaled air of cystic fibrosis children with bacterial airway infections. Pediatr Pulmonol 2005;40:494-499.
116. Rosenfeld M, Gibson RL, McNamara S, Emerson J, Burns JL, Castile R, Hiatt P, McCoy K, Wilson CB, Inglis A, et al. Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis. Pediatr Pulmonol 2001;32:356-366.
117. Hubeau C, Puchelle E, Gaillard D. Distinct pattern of immune cell population in the lung of human fetuses with cystic fibrosis. J Allergy Clin Immunol 2001;108:524-529.
118. Carpagnano GE, Barnes PJ, Francis J, Wilson N, Bush A, Kharitonov SA. Breath condensate pH in children with cystic fibrosis and asthma: a new noninvasive marker of airway inflammation? Chest 2004;125:2005-2010.
119. Long FR, Williams RS, Castile RG. Structural airway abnormalities in infants and young children with cystic fibrosis. J Pediatr 2004;144:154-161.
120. Martinez TM, Llapur CJ, Williams TH, Coates C, Gunderman R, Cohen MD, Howenstine MS, Coxson HO, Tepper RS. High-resolution computed tomography imaging of airway disease in infants with cystic fibrosis. Am J Respir Crit Care Med 2005;172:1133-1138.
121. Sly PD, Brennan S, Gangell C, de Klerk N, Murray C, Mott L, Stick SM, Robinson PJ, Robertson CF, Ranganathan SC. Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening. Am J Respir Crit Care Med 2009;180:146-152.
122. Tiddens HA. Detecting early structural lung damage in cystic fibrosis. Pediatr Pulmonol 2002;34:228-231.
123. de Jong PA, Nakano Y, Lequin MH, Mayo JR, Woods R, Pare PD, Tiddens HAWM. Progressive damage on high resolution computed tomography despite stable lung function in cystic fibrosis. Eur Respir J 2004;23:93-97.
124. de Jong PA, Ottink MD, Robben SGF, Lequin MH, Hop WCJ, Hendriks JJE, Pare PD, Tiddens HAWM. Pulmonary disease assessment in cystic fibrosis: comparison of CT scoring systems and value of bronchial and arterial dimension measurements. Radiology 2004;231:434-439.
125. Marchant JM, Masel JP, Dickinson FL, Masters IB, Chang AB. Application of chest high-resolution computer tomography in young children with cystic fibrosis. Pediatr Pulmonol 2001;31:24-29.
126. Brody AS, Klein JS, Molina PL, Quan J, Bean JA, Wilmott RW. High-resolution computed tomography in young patients with cystic fibrosis: distribution of abnormalities and correlation with pulmonary function tests. J Pediatr 2004;145: 32-38.
127. Demirkazik FB, Ariyurek OM, Ozcelik U, Gocmen A, Hassanabad HK, Kiper N. High resolution CT in children with cystic fibrosis: correlation with pulmonary functions and radiographic scores. Eur J Radiol 2001;37:54-59.