Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition

Clinical and Experimental Immunology

Volumn 160, Issue 3, 2010, Pages 461-465

  Choi, R Y ^a   Farquhar, C ^a   Juno, J ^b   Mbori Ngacha, D ^d   Lohman Payne, B ^a   Vouriot, F ^b   Wayne, S ^b   Tuff, J ^c   Bosire, R ^e   John Stewart, G ^a   Fowke, K ^b,d  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF MANITOBA   (Canada)

^c PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^d UNIVERSITY OF NAIROBI   (Kenya)

^e KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

Author keywords

CD4 receptor; Genetics; HIV; Mother to child transmission; Single nucleotide polymorphism

Indexed keywords

CD4 ANTIGEN; CYTIDINE; THYMIDINE; ZIDOVUDINE;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; HIGH RISK POPULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOGENETICS; INFANT; INFECTION RISK; KENYA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; VERTICAL TRANSMISSION; VIRUS IMMUNITY; VIRUS LOAD; WILD TYPE;

ADULT; ALLELES; ANTIGENS, CD4; COHORT STUDIES; FEMALE; GENE FREQUENCY; HIV INFECTIONS; HIV-1; HUMANS; INFANT; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS;

EID: 77952183967     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2010.04096.x     Document Type: Article

References (14)

1. Joint United Nations Programme on HIV/AIDS/World Health Organization (UNAIDS/WHO). AIDS epidemic update, December, 2006.
2. Dean M, Carrington M, Winkler C et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 1996 273 : 1856 1862.
3. Samson M, Libert F, Doranz BJ et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996 382 : 722 725. (Pubitemid 26282179)
4. Huang Y, Paxton WA, Wolinsky SM et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med 1996 2 : 1240 1243. (Pubitemid 26375409)
5. Liu R, Paxton WA, Choe S et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996 86 : 367 377. (Pubitemid 26272077)
6. Stewart GJ, Ashton LJ, Biti RA et al. Increased frequency of CCR-5 delta 32 heterozygotes among long-term non-progressors with HIV-1 infection. The Australian Long-Term Non-Progressor Study Group. AIDS 1997 11 : 1833 1838.
7. Lederman S, DeMartino JA, Daugherty BL et al. A single amino acid substitution in a common African allele of the CD4 molecule ablates binding of the monoclonal antibody, OKT4. Mol Immunol 1991 28 : 1171 1181.
8. Oyugi JO, Vouriot FC, Alimonti J et al. A common CD4 gene variant is associated with an increased risk of HIV-1 infection in Kenyan female commercial sex workers. J Infect Dis 2009 199 : 1327 1334.
9. Thaineua V, Sirinirund P, Tanbanjong A, Lallemant M, Soucat A, Lamboray JL. From research to practice: use of short course zidovudine to prevent mother-to-child HIV transmission in the context of routine health care in Northern Thailand. Southeast Asian J Trop Med Public Health 1998 29 : 429 442. (Pubitemid 128529658)
10. DeVange Panteleeff D, Emery S, Richardson BA et al. Validation of performance of the Gen-Probe human immunodeficiency virus type 1 viral load assay with genital swabs and breast milk samples. J Clin Microbiol 2002 40 : 3929 3937. (Pubitemid 35285770)
11. Emery S, Bodrug S, Richardson BA et al. Evaluation of performance of the Gen-Probe human immunodeficiency virus type 1 viral load assay using primary subtype A, C, and D isolates from Kenya. J Clin Microbiol 2000 38 : 2688 2695. (Pubitemid 30485151)
12. Panteleeff DD, John G, Nduati R et al. Rapid method for screening dried blood samples on filter paper for human immunodeficiency virus type 1 DNA. J Clin Microbiol 1999 37 : 350 353. (Pubitemid 29056402)
13. Fuller TC, Trevithick JE, Fuller AA, Colvin RB, Cosimi AB, Kung PC. Antigenic polymorphism of the T4 differentiation antigen expressed on human T helper/inducer lymphocytes. Hum Immunol 1984 9 : 89 102. (Pubitemid 14158066)
14. Houlgatte R, Scarmato P, el Marhomy S et al. HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4. J Immunol 1994 152 : 4475 4488. (Pubitemid 24134405)