Modulating the substrate specificity of LTA4H aminopeptidase by using chemical compounds and small-molecule-guided mutagenesis

ChemBioChem

Volumn 11, Issue 8, 2010, Pages 1120-1128

  Jiang, Xiaolu ^a   Zhou, Lu ^a   Wu, Yiran ^a,b   Wei, Dengguo ^a,b   Sun, Chunyi ^a   Jia, Jia ^a   Liu, Ying ^a   Lai, Luhua ^a,b  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Aminopeptidase activity; Hydrolases; Protein engineering; Selectivity; Small molecules

Indexed keywords

4 PHENOXYPHENOL; ALANINE; AMINOPEPTIDASE; ARGININE; CHEMICAL COMPOUND; DIPHENYL ETHER; EPOXIDE HYDROLASE; LEUKOTRIENE A4 HYDROLASE; MUTANT PROTEIN; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINOPEPTIDASES; CLONING, MOLECULAR; EPOXIDE HYDROLASES; GENE EXPRESSION; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHENYL ETHERS; POINT MUTATION; SUBSTRATE SPECIFICITY;

EID: 77952126957     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900788     Document Type: Article

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