Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 24, 2008, Pages 6549-6552

  Jiang, Xiaolu ^a   Zhou, Lu ^a   Wei, Dengguo ^a,b   Meng, Hu ^a   Liu, Ying ^a   Lai, Luhua ^a,b  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Activators; Diphenyl ether derivatives; Inhibitors; Leukotriene A4 hydrolase aminopeptidase

Indexed keywords

DIPHENYL ETHER DERIVATIVE; HYDROLASE; LEUKOTRIENE A4 HYDROLASE; LEUKOTRIENE A4 HYDROLASE AMINOPEPTIDASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME REGULATION; IC 50; MOLECULAR MODEL; NONHUMAN;

CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME ACTIVATION; EPOXIDE HYDROLASES; HUMANS; HYDROLYSIS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHENYL ETHERS; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

EID: 56249087623     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.044     Document Type: Article

References (13)

1. Samuelsson B. Science 220 (1983) 568
2. Funk C.D. Science 294 (2001) 1871
3. Haeggstrom J.Z. J. Biol. Chem. 279 (2004) 50639
4. Penning T.D. Curr. Pharm. Des. 7 (2001) 163
5. Haeggstrom J.Z., Wetterholm A., Vallee B.L., and Samuelsson B. Biochem. Biophys. Res. Commun. 173 (1990) 431
6. Minami M., Ohishi N., Mutoh H., Izumi T., Bito H., Wada H., Seyama Y., Toh H., and Shimizu T. Biochem. Biophys. Res. Commun. 173 (1990) 620
7. Orning L., Gierse J.K., and Fitzpatrick F.A. J. Biol. Chem. 269 (1994) 11269
8. Wetterholm A., and Haeggstrom J.Z. Biochim. Biophys. Acta 1123 (1992) 275
9. Orning L., and Fitzpatrick F.A. Biochemistry 31 (1992) 4218
10. Thunnissen M.M., Nordlund P., and Haeggstrom J.Z. Nat. Struct. Biol. 8 (2001) 131
11. Penning T.D., Chandrakumar N.S., Chen B.B., Chen H.Y., Desai B.N., Djuric S.W., Docter S.H., Gasiecki A.F., Haack R.A., Miyashiro J.M., Russell M.A., Yu S.S., Corley D.G., Durley R.C., Kilpatrick B.F., Parnas B.L., Askonas L.J., Gierse J.K., Harding E.I., Highkin M.K., Kachur J.F., Kim S.H., Krivi G.G., Villani-Price D., Pyla E.Y., and Smith W.G. J. Med. Chem. 43 (2000) 721
12. Orning L., Krivi G., and Fitzpatrick F.A. J. Biol. Chem. 266 (1991) 1375
13. Morris G.M., Goodsell D.S., Halliday R.S., Huey R., Hart W.E., Belew R.K., and Olson A.J. J. Comput. Chem. 19 (1998) 1639