Ser9Gly polymorphism of the DRD3 gene is associated with worse premorbid social functioning and an earlier age of onset in female but not male schizophrenic patients

Psychiatry Research

Volumn 177, Issue 1-2, 2010, Pages 266-267

  Godlewska, Beata Renata ^a   Olajossy Hilkesberger, Luiza ^b   Limon, Janusz ^a   Landowski, Jerzy ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 3 RECEPTOR; GLYCINE; SERINE;

ADULT; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; MORBIDITY; ONSET AGE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHIZOPHRENIA; SEX DIFFERENCE; SOCIAL INTERACTION; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS;

ADOLESCENT; ADULT; AGE OF ONSET; CHILD; FEMALE; GENE FREQUENCY; GENOME-WIDE ASSOCIATION STUDY; GLYCINE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, DOPAMINE D3; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SERINE; SEX CHARACTERISTICS; SOCIAL BEHAVIOR; YOUNG ADULT;

EID: 77952107468     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2010.02.012     Document Type: Letter

References (6)

1. Faraone S.V., Green A.I., Seidman L.J., Tsuang M.T. "Schizotaxia": clinical implications and new directions for research. Schizophrenia Bulletin 2001, 27:1-18.
2. Joyce J.N., Millan M.J. Dopamine D3 receptor antagonists as therapeutic agents. Drug Discovery Today 2005, 10:917-925.
3. Lane H.Y., Hsu S.K., Liu Y.C., Chang Y.C., Huang C.H., Chang W.H. Dopamine D3 receptor Ser9Gly polymorphism and risperidone response. Journal of Clinical Psychopharmacology 2005, 25:6-11.
4. Lannfelt L., Sokoloff P., Martres M., Pilon C., Giros B., Jonsson E., Sedvall G., Schwartz J.C. Amino acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders. Psychiatric Genetics 1992, 2:249-256.
5. Lundstrom K., Turpin M.P. Proposed schizophrenia-related gene polymorphism: expression of the Ser9Gly mutant human dopamine D3 receptor with the Semliki Forest virus system. Biochemical and Biophysical Research Communications 1996, 225:1068-1072.
6. Phillips L. Case history data and prognosis in schizophrenia. Journal of Nervous and Mental Disease 1953, 117:515-525.