1-(2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 10, 2010, Pages 3125-3128

  Tollefson, Michael B ^a   Acker, Brad A ^a   Jacobsen, E J ^a   Hughes, Robert O ^a   Walker, John K ^a   Fox, David N A ^b   Palmer, Michael J ^b   Freeman, Sandra K ^a   Yu, Ying ^a   Bond, Brian R ^a  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Phosphodiesterase 5 inhibitors

Indexed keywords

DOFETILIDE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; PHOSPHODIESTERASE VI; PHOSPHODIESTERASE XI; PIPERAZINE DERIVATIVE; PIPERAZINONE DERIVATIVE; SILDENAFIL; UNCLASSIFIED DRUG;

ARTICLE; DRUG ABSORPTION; DRUG HALF LIFE; DRUG POTENCY; DRUG SAFETY; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; ERECTILE DYSFUNCTION; HUMAN; HYPERTENSION; IC 50; LIVER MICROSOME; PULMONARY HYPERTENSION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; ENZYME INHIBITORS; HUMANS; MICROSOMES, LIVER; PATCH-CLAMP TECHNIQUES; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77952104808     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.106     Document Type: Article

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