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Volumn 19, Issue 15, 2009, Pages 4088-4091

Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors

Author keywords

Inhibitors; PDE11; PDE5; PDE6

Indexed keywords

2 ARYL,(N8) ALKYL 6 AMINO PYRIDO[3,2B]PYRAZINONE DERIVATIVE; PHENYL QUINOLIN 4 ONE DERIVATIVE; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; UNCLASSIFIED DRUG;

EID: 67649946944     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.012     Document Type: Article
Times cited : (21)

References (16)
  • 12
    • 67649991784 scopus 로고    scopus 로고
    • Heasley, S. E.; Jacobsen, E. J.; Walker, J. K.; Hughes, R. O.; Freskos, J.; Brown, D. L.; Fobian, Y. M.; Owen, D.; Mischke, B. V.; Tollefson, M. B.; Molyneaux, J.; Blevis-Bal, R.; Maddux, T.; Brown, D. G.; Moon, J. B.; Phillips, C.; Rogier, D. J.; Benson, A. Abstracts of Papers, 236th National Meeting of the American Chemical Society, Philadelphia, PA, Aug 17-21, 2008; American Chemical Society: Washington, DC, 2008; MEDI-397.
    • Heasley, S. E.; Jacobsen, E. J.; Walker, J. K.; Hughes, R. O.; Freskos, J.; Brown, D. L.; Fobian, Y. M.; Owen, D.; Mischke, B. V.; Tollefson, M. B.; Molyneaux, J.; Blevis-Bal, R.; Maddux, T.; Brown, D. G.; Moon, J. B.; Phillips, C.; Rogier, D. J.; Benson, A. Abstracts of Papers, 236th National Meeting of the American Chemical Society, Philadelphia, PA, Aug 17-21, 2008; American Chemical Society: Washington, DC, 2008; MEDI-397.
  • 13
    • 67649985563 scopus 로고    scopus 로고
    • note
    • The coordinates have been deposited in the PDB under accession code 3HDZ.
  • 14
    • 67649985562 scopus 로고    scopus 로고
    • N, Fobian, Y. M, Walker. J. K, Hughes, R, Jacobsen, E. J, Tollefson, M. B, Brown, D. G, Mischke, B. V, Molyneaux, J. M.PCTWO 07/020521
    • Brown, D. L.; Owen, D. R.; Phillips, C.; Palmer, M. J.; Bell, A. S.; Freskos, J. N.; Fobian, Y. M.; Walker. J. K.; Hughes, R.; Jacobsen, E. J.; Tollefson, M. B.; Brown, D. G.; Mischke, B. V.; Molyneaux, J. M.PCTWO 07/020521..
    • Brown, D.L.1    Owen, D.R.2    Phillips, C.3    Palmer, M.J.4    Bell, A.S.5    Freskos, J.6
  • 15
    • 67649966939 scopus 로고    scopus 로고
    • note
    • The Pfizer Institutional Animal Care and Use Committee reviewed and approved the animal use in these studies. The animal care and use program is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care, International.
  • 16
    • 67649963922 scopus 로고    scopus 로고
    • note
    • PK experiments were conducted in Sprague Dawley rats under the following conditions; IV: 2 mpk (n = 3) vehicle: 70% PEG400/20% 0.05 M citrate buffer/10% ethanol, pH 5; PO: 2 mpk (n = 3) vehicle: 0.5% methylcellulose/0.1% Tween 80 in 50 nM citric acid, pH 5.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.