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Volumn 19, Issue 15, 2009, Pages 4088-4091
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Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors
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Author keywords
Inhibitors; PDE11; PDE5; PDE6
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Indexed keywords
2 ARYL,(N8) ALKYL 6 AMINO PYRIDO[3,2B]PYRAZINONE DERIVATIVE;
PHENYL QUINOLIN 4 ONE DERIVATIVE;
PHOSPHODIESTERASE V;
PHOSPHODIESTERASE V INHIBITOR;
SILDENAFIL;
UNCLASSIFIED DRUG;
ARTICLE;
DRUG IDENTIFICATION;
DRUG INHIBITION;
DRUG STRUCTURE;
DRUG SYNTHESIS;
STRUCTURE ACTIVITY RELATION;
SUBSTITUTION REACTION;
X RAY CRYSTALLOGRAPHY;
ANIMALS;
CATALYTIC DOMAIN;
CHEMISTRY, PHARMACEUTICAL;
CRYSTALLOGRAPHY, X-RAY;
CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5;
CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6;
DRUG DESIGN;
HUMANS;
HYDROGEN-ION CONCENTRATION;
INHIBITORY CONCENTRATION 50;
PHOSPHODIESTERASE 5 INHIBITORS;
PHOSPHODIESTERASE INHIBITORS;
PHOSPHORIC DIESTER HYDROLASES;
PROTEIN STRUCTURE, TERTIARY;
PYRAZINES;
RATS;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 67649946944
PISSN: 0960894X
EISSN: None
Source Type: Journal
DOI: 10.1016/j.bmcl.2009.06.012 Document Type: Article |
Times cited : (21)
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References (16)
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