Uptake of donor lymphocytes treated with 8-methoxypsoralen and ultraviolet A light by recipient dendritic cells induces CD4+CD25+Foxp3+ regulatory T cells and down-regulates cardiac allograft rejection

Biochemical and Biophysical Research Communications

Volumn 395, Issue 4, 2010, Pages 540-546

  Zheng, De Hua ^a   Dou, Li Ping ^b   Wei, Yu Xiang ^a   Du, Guo Sheng ^a   Zou, Yi Ping ^a   Song, Ji Yong ^a   Zhu, Zhi Dong ^a   Cai, Ming ^a   Qian, Ye Yong ^a   Shi, Bing Yi ^a  

^a 309TH HOSPITAL OF PLA   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Allograft rejection; Dendritic cells; Extracorporeal photopheresis; Negative immune regulation; Regulatory T cells

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; METHOXSALEN; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC GRAFT REJECTION; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL MATURATION; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DONOR LYMPHOCYTE INFUSION; DOWN REGULATION; DRUG UPTAKE; GRAFT RECIPIENT; IMMUNOMODULATION; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; NONHUMAN; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; PUVA; RAT; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; TH2 CELL; TRANSCRIPTION INITIATION; ULTRAVIOLET A RADIATION;

ANIMALS; ANTIGENS, CD4; DENDRITIC CELLS; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNOMODULATION; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; METHOXSALEN; PHAGOCYTOSIS; PHOTOPHERESIS; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; SPLEEN; T-LYMPHOCYTES, REGULATORY; TH2 CELLS; ULTRAVIOLET RAYS;

EID: 77952102861     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.04.062     Document Type: Article

References (17)

1. Maeda A. Extracorporeal photochemotherapy. J. Dermatol. Sci. 54 (2009) 150-156
2. Heshmati F. Mechanisms of action of extracorporeal photochemotherapy. Transfus. Apher. Sci. 29 (2003) 61-70
3. Xia C.Q., Campbell K.A., and Clare-Salzler M.J. Extracorporeal photopheresis-induced immune tolerance: a focus on modulation of antigen-presenting cells and induction of regulatory T cells by apoptotic cells. Curr. Opin. Organ. Transplant. 14 (2009) 338-343
4. Craciun L.I., Stordeur P., Schandene L., et al. Increased production of interleukin-10 and interleukin-1 receptor antagonist after extracorporeal photochemotherapy in chronic graft-versus-host disease. Transplantation 15 (2002) 995-1000
5. Gorgun G., Miller K.B., and Foss F.M. Immunologic mechanisms of extracorporeal photochemotherapy in chronic graft-versus-host disease. Blood 100 (2002) 941-947
6. C.H.Qiu, Y. Miyake, H. Kaise, et al., Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens, J. Immunol. 182 (2009) 4127-4136.
7. Ono K., and Lindsey E.S. Improved technique of heart transplantation in rats. J. Thorac. Cardiovasc. Surg. 57 (1969) 225-229
8. Erwig L.P., and Henson P.M. Immunological consequences of apoptotic cell phagocytosis. Am. J. Pathol. 171 (2007) 2-8
9. Xu W., Roos A., Daha M.R., et al. Dendritic cell and macrophage subsets in the handling of dying cells. Immunobiology 211 (2006) 567-575
10. Lamioni A., Parisi F., Isacchi G., et al. The immunological effects of extracorporeal photopheresis unraveled: induction of tolerogenic dendritic cells in vitro and regulatory T cells in vivo. Transplantation 79 (2005) 846-850
11. Di Renzo M., Sbano P., De Aloe G., et al. Extracorporeal photopheresis affects co-stimulatory molecule expression and interleukin-10 production by dendritic cells in graft-versus-host disease patients. Clin. Exp. Immunol. 151 (2008) 407-413
12. Corinti S., Albanesi C., la Sala A., et al. Regulatory activity of autocrine IL-10 on dendritic cell functions. J. Immunol. 166 (2001) 4312-4318
13. Steinbrink K., Graulich E., Kubsch S., et al. CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity. Blood 99 (2002) 2468-2476
14. Wood K.J., and Sawitzki B. Interferon gamma: a crucial role in the function of induced regulatory T cells in vivo. Trends Immunol. 27 (2006) 183-187
15. Tiemessen M.M., Jagger A.L., Evans H.G., et al. CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc. Natl. Acad. Sci. USA 104 (2007) 19446-19451
16. Ziegler S.F., and Buckner J.H. FOXP3 and the regulation of Treg/Th17 differentiation. Microbes Infect. 11 (2009) 594-598
17. Min W.P., Zhou D., Ichim T.E., et al. Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J. Immunol. 170 (2003) 1304-1312