Selective and rapid monitoring of dual platelet inhibition by aspirin and P2Y12 antagonists by using multiple electrode aggregometry

Thrombosis Journal

Volumn 8, Issue , 2010, Pages

  Penz, Sandra M ^a   Bernlochner, Isabell ^a   Tóth, Orsolya ^a,b   Lorenz, Reinhard ^a   Calatzis, Andreas ^a   Siess, Wolfgang ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF PÉCS   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; APYRASE; ARACHIDONIC ACID; ARC 69931MX; CANGRELOR; CLOPIDOGREL; HIRUDIN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; COMBINATION CHEMOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MONITORING; DRUG SELECTIVITY; EX VIVO STUDY; FEASIBILITY STUDY; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; LOADING DRUG DOSE; LOW DRUG DOSE; MONOTHERAPY; MULTIPLE ELECTRODE AGGREGOMETRY; NORMAL HUMAN; SINGLE DRUG DOSE; THROMBOCYTE AGGREGATION INHIBITION; TREATMENT DURATION;

EID: 77952080114     PISSN: None     EISSN: 14779560     Source Type: Journal    
DOI: 10.1186/1477-9560-8-9     Document Type: Article

References (29)

1. World Health Organisation. World health statistics 2008. 2008, WHO Press, World Health Organization. Geneva, Switzerland., http://www.who.int/whosis/whostat/EN_WHS08_Full.pdf
2. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002, 324:71-86. 10.1136/bmj.324.7329.71, 64503, 11786451.
3. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet 1996, 348:1329-1339. 10.1016/S0140-6736(96)09457-3, 8918275.
4. Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Ruzyllo W, Gottlieb S, Neumann FJ, Ardissino D, De Servi S, Murphy SA, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007, 357:2001-2015. 10.1056/NEJMoa0706482, 17982182.
5. Meadows TA, Bhatt DL. Clinical aspects of platelet inhibitors and thrombus formation. Circ Res 2007, 100:1261-1275. 10.1161/01.RES.0000264509.36234.51, 17495233.
6. Schomig A, Neumann FJ, Kastrati A, Schuhlen H, Blasini R, Hadamitzky M, Walter H, Zitzmann-Roth EM, Richardt G, Alt E, et al. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Engl J Med 1996, 334:1084-1089. 10.1056/NEJM199604253341702, 8598866.
7. Maree AO, Fitzgerald DJ. Variable platelet response to aspirin and clopidogrel in atherothrombotic disease. Circulation 2007, 115:2196-2207. 10.1161/CIRCULATIONAHA.106.675991, 17452618.
8. Gum PA, Kottke-Marchant K, Welsh PA, White J, Topol EJ. A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease. J Am Coll Cardiol 2003, 41:961-965. 10.1016/S0735-1097(02)03014-0, 12651041.
9. Chen WH, Cheng X, Lee PY, Ng W, Kwok JY, Tse HF, Lau CP. Aspirin resistance and adverse clinical events in patients with coronary artery disease. Am J Med 2007, 120:631-635. 10.1016/j.amjmed.2006.10.021, 17602938.
10. Geisler T, Langer H, Wydymus M, Gohring K, Zurn C, Bigalke B, Stellos K, May AE, Gawaz M. Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation. Eur Heart J 2006, 27:2420-2425. 10.1093/eurheartj/ehl275, 17005534.
11. Hochholzer W, Trenk D, Bestehorn HP, Fischer B, Valina CM, Ferenc M, Gick M, Caputo A, Buttner HJ, Neumann FJ. Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement. J Am Coll Cardiol 2006, 48:1742-1750. 10.1016/j.jacc.2006.06.065, 17084243.
12. Buonamici P, Marcucci R, Migliorini A, Gensini GF, Santini A, Paniccia R, Moschi G, Gori AM, Abbate R, Antoniucci D. Impact of platelet reactivity after clopidogrel administration on drug-eluting stent thrombosis. J Am Coll Cardiol 2007, 49:2312-2317. 10.1016/j.jacc.2007.01.094, 17572245.
13. Marcucci R, Gori AM, Paniccia R, Giusti B, Valente S, Giglioli C, Buonamici P, Antoniucci D, Abbate R, Gensini GF. Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month follow-up. Circulation 2009, 119:237-242. 10.1161/CIRCULATIONAHA.108.812636, 19118249.
14. Sibbing D, Braun S, Jawansky S, Vogt W, Mehilli J, Schomig A, Kastrati A, von Beckerath N. Assessment of ADP-induced platelet aggregation with light transmission aggregometry and multiple electrode platelet aggregometry before and after clopidogrel treatment. Thromb Haemost 2008, 99:121-126.
15. Lordkipanidze M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG. A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease. Eur Heart J 2007, 28:1702-1708. 10.1093/eurheartj/ehm226, 17569678.
16. Gorog DA, Sweeny JM, Fuster V. Antiplatelet drug 'resistance'. Part 2: laboratory resistance to antiplatelet drugs-fact or artifact?. Nat Rev Cardiol 2009, 6:365-373.
17. Jennings I, Woods TA, Kitchen S, Walker ID. Platelet function testing: practice among UK National External Quality Assessment Scheme for Blood Coagulation participants, 2006. J Clin Pathol 2008, 61:950-954. 10.1136/jcp.2008.057174, 18663056.
18. Geiger J, Teichmann L, Grossmann R, Aktas B, Steigerwald U, Walter U, Schinzel R. Monitoring of clopidogrel action: comparison of methods. Clin Chem 2005, 51:957-965. 10.1373/clinchem.2004.047050, 15817818.
19. Toth O, Calatzis A, Penz S, Losonczy H, Siess W. Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood. Thromb Haemost 2006, 96:781-788.
20. Cardinal DC, Flower RJ. The electronic aggregometer: a novel device for assessing platelet behavior in blood. J Pharmacol Methods 1980, 3:135-158. 10.1016/0160-5402(80)90024-8, 7392654.
21. Mueller T, Dieplinger B, Poelz W, Haltmayer M. Utility of the PFA-100 Instrument and the Novel Multiplate Analyzer for the Assessment of Aspirin and Clopidogrel Effects on Platelet Function in Patients With Cardiovascular Disease. Clin Appl Thromb Hemost 2008, 15(6):652-9. 10.1177/1076029608322547, 18805846.
22. Sibbing D, Braun S, Morath T, Mehilli J, Vogt W, Schomig A, Kastrati A, von Beckerath N. Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis. J Am Coll Cardiol 2009, 53:849-856. 10.1016/j.jacc.2008.11.030, 19264241.
23. Haseruck N, Erl W, Pandey D, Tigyi G, Ohlmann P, Ravanat C, Gachet C, Siess W. The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors. Blood 2004, 103:2585-2592. 10.1182/blood-2003-04-1127, 14645014.
24. Storey RF, Oldroyd KG, Wilcox RG. Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes. Thromb Haemost 2001, 85:401-407.
25. Gachet C. ADP receptors of platelets and their inhibition. Thromb Haemost 2001, 86:222-232.
26. Bonello L, Camoin-Jau L, Arques S, Boyer C, Panagides D, Wittenberg O, Simeoni MC, Barragan P, Dignat-George F, Paganelli F. Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective study. J Am Coll Cardiol 2008, 51:1404-1411. 10.1016/j.jacc.2007.12.044, 18387444.
27. Schwarz UR, Geiger J, Walter U, Eigenthaler M. Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets--definition and detection of ticlopidine/clopidogrel effects. Thromb Haemost 1999, 82:1145-1152.
28. Siess W, Siegel FL, Lapetina EG. Arachidonic acid stimulates the formation of 1,2-diacylglycerol and phosphatidic acid in human platelets. Degree of phospholipase C activation correlates with protein phosphorylation, platelet shape change, serotonin release, and aggregation. J Biol Chem 1983, 258:11236-11242.
29. Siess W. Molecular mechanisms of platelet activation. Physiol Rev 1989, 69:58-178.