Estimation of nicotine dose after low-level exposure using plasma and urine nicotine metabolites

Cancer Epidemiology Biomarkers and Prevention

Volumn 19, Issue 5, 2010, Pages 1160-1166

  Benowitz, Neal L ^a   Dains, Katherine M ^a   Dempsey, Delia ^a   Yu, Lisa ^a   Jacob III, Peyton ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3' HYDROXYCOTININE; 3' HYDROXYCOTININE GLUCURONIDE; COTININE; COTININE GLUCURONIDE; CREATININE; GLUCURONIDE; NICOTINE; NICOTINE DERIVATIVE; NICOTINE GLUCURONIDE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CREATININE URINE LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PASSIVE SMOKING; PRIORITY JOURNAL; URINALYSIS;

ADULT; BIOLOGICAL MARKERS; COTININE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUCURONATES; HUMANS; MALE; MIDDLE AGED; NICOTINE; SMOKING; TOBACCO SMOKE POLLUTION; YOUNG ADULT;

EID: 77952078223     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-09-1303     Document Type: Article

References (11)

1. Benowitz NL. Cotinine as a biomarker of environmental tobacco smoke exposure. Epidemiol Rev 1996;18:188-204. (Pubitemid 27082089)
2. Benowitz NL, Dains KM, Dempsey D, Herrera B, Yu L, Jacob P III. Urine nicotine metabolite concentrations in relation to plasma cotinine during low-level nicotine exposure. Nicotine Tob Res 2009;11: 954-960
3. Benowitz NL, Jacob P III, Fong I, Gupta S. Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine. J Pharmacol Exp Ther 1994;268:296-303. (Pubitemid 24039102)
4. Joseph AM, Hecht SS, Murphy SE, et al. Relationships between cigarette consumption and biomarkers of tobacco toxin exposure. Cancer Epidemiol Biomarkers Prev 2005;14:2963-2968
5. Feng S, Kapur S, Sarkar M, et al. Respiratory retention of nicotine and urinary excretion of nicotine and its five major metabolites in adult male smokers. Toxicol Lett 2007;173:101-106 (Pubitemid 47361551)
6. Jacob P III, Benowitz NL, Shulgin AT. Synthesis of optically pure deuterium-labeled nicotine, nornicotine and cotinine. J Labelled Comp Radiopharm 1988;25:1117-1128
7. Dempsey D, Tutka P, Jacob P III, et al. Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity. Clin Pharmacol Ther 2004;76:64-72. (Pubitemid 38844735)
8. Benowitz NL, Swan GE, Jacob P III, Lessov-Schlaggar CN, Tyndale RF. CYP2A6 genotype and the metabolism and disposition kinetics of nicotine. Clin Pharmacol Ther 2006;80:457-467 (Pubitemid 44767882)
9. Hukkanen J, Jacob P III, Benowitz NL. Metabolism and disposition kinetics of nicotine. Pharmacol Rev 2005;57:79-115.
10. Scherer G, Engl J, Urban M, Gilch G, Janket D, Riedel K. Relationship between machine-derived smoke yields and biomarkers in cigarette smokers in Germany. Regul Toxicol Pharmacol 2007;47:171-183 (Pubitemid 46209369)
11. Benowitz NL, Jacob P III. Effects of cigarette smoking and carbon monoxide on nicotine and cotinine metabolism. Clin Pharmacol Ther 2000;67:653-659