Analytical methods for the determination of chlorhexidine: A review

Critical Reviews in Analytical Chemistry

Volumn 40, Issue 2, 2010, Pages 89-101

  Fiorentino, Flávia Angélica Másquio ^a   Corrêa, Marcos Antonio ^a   Salgado, Hérida Regina Nunes ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Chlorhexidine; Methods of analysis; Review

Indexed keywords

ANALYTICAL METHOD; ANALYTICAL PROCEDURE; BIOLOGICAL FLUIDS; CHLORHEXIDINE; COLORIMETRIC REACTION; METHODS OF ANALYSIS; PHARMACOKINETIC STUDIES; SOLID-PHASE EXTRACTION;

CAPILLARY ELECTROPHORESIS; CUSTOMER SATISFACTION; EXTRACTION; TOTAL QUALITY MANAGEMENT; VETERINARY MEDICINE;

QUALITY CONTROL;

ANTIBIOTICS; CHEMICAL COMPOUND; CHROMATOGRAPHY; COLORIMETRY; ELECTROKINESIS; MEDICINE; REACTION KINETICS; SPECTROMETRY;

NEGIBACTERIA; POSIBACTERIA;

EID: 77952072086     PISSN: 10408347     EISSN: 15476510     Source Type: Journal    
DOI: 10.1080/10408340903232020     Document Type: Review

References (70)

1. P. G. Mazzola, T. C.V. Penna, and A. M. S. Martins, Determination of decimal reduction time (D value) of chemical agents used in hospitals for disinfection purposes. BMC Infectious Disease 3(24) (2003):1-10.
2. A. R. R. Genaro, (Ed.) Remington: The Science and Pratice of Pharmacy. 21st. (Williams & Wilkins, Philadelphia, 2005), Ch. 90, 1626-1628.
3. D. J. Weber, W. A. Rutala, and E. E. Sickbert-Bennett, Outbreaks associated with contaminated antiseptics and disinfectants. Antimicrobial Agents Chemotheraphy 51(12) (2007):4217-4224.
4. I. E. Alcamo, Fundamentals of Microbiology, 6th ed. (Jones and Barttlett Publ.: Sudbury, Massachusetts, 2001).
5. F. B. Zanatta and C. K. R̈osing, Chlorhexidine: Action's mechanism and recent evidences of it's efficacy over supragingival biofilm context. Scientifica 1(2) (2007):35-43.
6. European Pharmacopoeia, 5th ed. (Council of Europe (ed.), Strasbourg, 2005).
7. United States Pharmacopoeia 31st ed, National Formulary XXVI; Rockville, MD, US Pharmacopoeial Convention: 2008.
8. British Pharmaceutical Codex 1973. (Her Majesty's Stationery Office, London 1973).
9. L. Thomas, J. Y. Maillard, R. J.W. Lambert, and A. D. Russell, Development of resistance to chlorhexidine diacetate in Pseudomonas aeruginosa and the effect of a residual concentration. Journal of Hospital Infection 46 (2000):297-303.
10. C. L. Mullany, G. L. Darmstadt, S. K. Khatry, J. Katz, S. C. Leclerq, S. Shrestha, R, Adhikari, and J. M. Tielsch, Topical applications of chlorhexidine to the umbilical cord for prevention of omphalitis and neonatal mortality in southern Nepal: A community-based, cluster-randomised trial. Lancet 367 (2006):910-918.
11. L. Havlíková, L. Matysová, L. Nováková, R. Hájková, and P. Solich, HPLC determination of chlorhexidine gluconate and pchloroaniline in topical ointment. Journal of Pharmaceutical and Biomedical Analysis 43 (2007):1169-1173.
12. N. Perrins and R. Bond, Synergistic inhibition of the growth in vitro of Microsporum canis by miconazole and chlorhexidine. Veterinary Dermatology 14 (2003):99-102.
13. T. J. Karpanen, T. Worthington, E. R. Hendry, B. R. Conway, and P. A. Lambert, Antimicrobial efficacy of chlorhexidine digluconate alone and in combination with eucalyptus oil, tea tree oil and thymol against planktonic and biofilm cultures of Staphylococcus epidermidis. Journal of Antimicrobial Chemotherapy 62 (2008):1031-1036.
14. T. Gajadhar, A. Lara, P. Sealy, and A. A. Adesiyun, Microbial contamination of desinfectants and antiseptics in four major hospitals in Trinidad. Revista Panamericana de Salud Publica 14(3) (2003):193-200.
15. L. R. Trabulsi and F. Alterthum, Microbiologia, 4th ed. (São Paulo, Atheneu, 2005).
16. C. V. G. Amorin, C. E. Aun, and M. P. Mayer, Susceptibility of some oral microorganisms to chlorhexidine and paramonochlorophenol. Brazilian Oral Research 18(3) (2004):242-246.
17. Martindale: The complete drug reference, 35th ed. (Pharmaceutical Press, London, 2007).
18. L. E. Stevens, J. R. Durrwachter, and D. O. Helton, Analysis of chlorhexidine sorption in soft contact lenses by catalytic oxidation of (14C) chlorhexidine and by liquid chromatography. Journal of Pharmaceutical Science 75(1) (1986):83-86.
19. Y. Ha and A. P. Cheung, Newstability-indicating high performance liquid chromatography assay and proposed hydrolytic pathways of chlorhexidine. Journal of Pharmaceutical and Biomedical Analysis 14 (1996):1327-1334.
20. E. M. Abad-Villar, S. F. Etter, M. A. Thiel, and P. C. Hauser, Determination of chlorhexidine digluconate and polyhexamethylene biguanide in eye drops by capillary electrophoresis with contactless conductivity detection. Analytica Chimica Acta 561 (2006):133-137.
21. G. J. Tortora, B. R. Funke, and C. L. Case, Microbiologia, 8th ed. (Artmed, Porto Alegre, Brazil, 2006).
22. E. A. Neidle and J. A. Yagiela, Farmacologia e terapêutica para dentistas, 3rd ed. Guanabara Koogan, Rio de Janeiro, 1991.
23. G. Wu and X. Liu, Characterization of predominant bacteria isolates from clean rooms in a pharmaceutical production unit. Journal of Zhejiang University Science B 8(9) (2007):666-672.
24. A. M. J. Bambace, E. J. A. Barros, S. S. F. Santos, and A. O. C. Jorge, Eficácia de soluções aquosas de clorexidina para desinfetantes de superfícies. Revista Biociência 9(2) (2003):73-81.
25. V. R. Hebert, J. R. Diddleton, E. Tomaszewska, and L. K. Fox, Methodology for quantifying residues of chlorhexidine in raw dairy milk. Journal of Agricultural and Food Chemistry 51 (2003):567-570.
26. H. Baker, O. Frank, B. DeAngelis, and E. R. Baker, Biocidal action of chlorhexidine is annulled by nicotinic acid. Antimicrobial Agents Chemotheraphy 38(10) (1994):2458-2459.
27. E. N. Southern, G. B. McCombs, S. L. Tolle, and K. Marinak, The comparative effects of 0.12% chlorhexidine and herbal oral rinse on dental plaque-induced gingivitis. Journal of Dental Hygiene 80(1) (2006):1-9.
28. P. P. Gontijo-Filho, M. L. N. Morais, H. M. S. Loureiro, and G. R. G. Armoa, Avaliação in vitro de alguns sabões medicinais disponíveis no Brasil. Revista Brasileira de Cirurgia 74(4) (1984):181-183.
29. British Pharmacopoeia 2005 (Her Majesty's Stationery Office, London, 2005).
30. K. Siefert, D. Casagrande, and H. Silberman, Analysis of chlorhexidine via gas-liquid chromatography. Journal of Chromatography 109 (1975):193-198.
31. W. H. Doub, D. D. Ruhi, B. Hart, P. R. Mehelic, and L. K. Revelle, Gradient liquid chromatographic method for determination of chlorhexidine and its degradation products in bulk material. Journal of AOAC International 79(3) (1996):636-639.
32. W. K. Gavlick and P. K. Davis, Gas chromatographic determination of p-chloroaniline in a chlorhexidine digluconate-containing alcohol foam surgical scrub product. Journal of AOAC International 77(3) (1994):583-586.
33. L. K. Revelle, W. H. Doub, R. T. Wilson, M. H. Harris, and A. M. Rutter, Identification and isolation of chlorhexidine digluconate impurities. Pharmaceutical Research 10(12) (1993): 1777-1784.
34. P. Bosnevoll, P. Lökken, G. Rölla, and P. N. Paus, Retention of chlorhexidine in the human oral cavity after mouth rinses. Archives of Oral Biology 19 (1974):209-212.
35. J. E. Jensen and F. Christensen, A study of the elimination of chlorhexidine from the oral cavity using a new spectrophotometric method. Journal of Periodontal Research 6 (1971):306-311.
36. J. de Vries, J. Ruben, and J. Arends, Determination of chlorhexidine in saliva and in aqueous solutions. Caries Research 25 (1991):410-414.
37. Y.W. F. Lam, D. C. N. Chan, S. Y. Rodriguez, J. H. Lintakoon, and T-H. LAM, Sensitive high-performance liquid chromatographic assay for the determination of chlorhexidine in saliva. Journal of Chromatography 612 (1993):166-171.
38. N. J. Medlicott, D. G. Ferry, I. G. Tucker, M. J. Rathbone, D. W. Holborow, and D. S. Jones, High performance liquid chromatographic (HPLC) assay for the determination of chlorhexidine in saliva film. Journal of Liquid Chromatography 17(7) (1994):1605-1620.
39. J. Pesonem, J. Holmalahti, and J. Pohjola, Determination of chlorhexidine in saliva using high-performance liquid chromatography. Journal of Chromatography B: Biomedical Applications 665 (1995):222-225.
40. F. M. Musteata and J. Pawliszyn, Assay of stability, free and total concentration of chlorhexidine in saliva by solid phase microextraction. Journal of Pharmaceutical and Biomedical Analysis 37 (2005):1015-1024.
41. M. H. Gaffney, M. Cooke, and R. Simpson, Improved method for the determination of chlorhexidine in urine. Journal of Chromatography 306 (1984):303-313.
42. P. Wainwright and M. Cooke, Direct determination of chlorhexidine in urine by high-performance liquid chromatography. Analyst 111 (1986):1343-1344.
43. C. E. Houston, P. Wainwright, M. Cooke, and R. Simpson, Highperformance liquid chromatographicmethod for the determination of chlorhexidine. Journal of Chromatography 237 (1982):457-464.
44. L. R. Brougham, H. Cheng, and K. A. Pittman, Sensitive highperformance liquid chromatographicmethod for the determination of chlorhexidine in human serum and urine. Journal of Chromatography 383 (1986):365-373.
45. H. Below, N. Lehan, and A. Kramer, HPLC determination of the antiseptic agent chlorhexidine and its degradation products 4-chloroaniline and 1-chloro-4-nitrobenzene in serum and urine. Microchimica Acta 146 (2004):129-135.
46. K. Kudo, N. Ikeda, A. Kiyoshima, Y. Hino, N. Nishida, and N. Inoue, Toxicological analysis of chlorhexidine in human serum using HPLC on a polymer-coated ODS column. Journal of Analytical Toxicology 26 (2002):119-122.
47. K. Usui, T. Hishinuma, H. Yamamguchi, N. Tachiiri, and J. Goto, Determination of chlorhexidine (CHD) and nonylphenolethoxylates (NPEOn) using LC-ESI-MS method and application to hemolyzed blood. Journal of Chromatography B 831 (2006):105-109.
48. F. Bailey, P. N. Brittain, and B. F. Williamson, Automated chromatographic determination of chlorhexidine in pharmaceutical preparations. Journal of Chromatography 109 (1975):305-312.
49. M. Bauer, L. Mailhe, D. Menard, and J.-P. Rouanet, Dosage de la chlorhexidine et de la tétracaine dans des préparations pharmaceutiques par chromatographie liquide de paires d'ions sur phase graffée type nitrile. Journal of Chromatography 259 (1983):360-366.
50. M. Bauer, C. Degude, and L. Mailhe, Simultaneous determination of chlorhexidine, tetracaine and their degradation products by íon-pair chromatography. Journal of Chromatography 315 (1984):457-464.
51. A. Richard, M. Elbaz, and G. Andermann, Determination of 4- chloroaniline and chlorhexidine digluconate by ion-pair reversedphase high-performance liquid chromatography. Journal of Chromatography 298 (1984):356-359.
52. L. Gagliardi, A. Amato, A. Basili, G. Cavazzutti, E. Federici, F. Chimenti, M. G. Casanova, E. Gattavecchia, and D. Tonelli, Determination of preservatives in cosmetic products by ion-pair reversed-phase high performance liquid chromatography. III. Journal of Chromatography 348 (1985):321-326.
53. O. Y.-P. Hu, S.-Y., Wang, Y.-J. Fang, Y.-H. Chen, and M.-L. King, Simultaneous determination of thimerosal and chlorhexidine in solutions for soft contact lenses and its applications in stability studies. Journal of Chromatography 523 (1991):321-326.
54. W. K. Gavlick, High-performance liquid chromatographic analysis of chlorhexidine and p-chloroaniline using a specialty column and a photodiode-array detector. Journal of Chromatography 623 (1992):375-380.
55. S. Izumoto, Y. Machida, H. Nishi, K. Nakamura, H. Nakai, T. Sato, Chromatography of crotamiton and its applications to the determination of active ingredients in ointments. Journal of Pharmaceutical and Biomedical Analysis 15 (1997):1457-1466.
56. D. Bonazzi, V. Andrisano, R. Gatti, and V. Cavrini, Analysis of pharmaceutical creams: A useful approach based on solid-phase extraction (SPE) and UV spectrophotometry. Journal of Pharmaceutical and Biomedical Analysis 13 (1995):1321-1329.
57. L. Miribel, J. L. Brazier, F. Comet, and D. Lecompte, Gas-liquid chromatographic determination of chlorhexidine in pharmaceutical formulations. Journal of Chromatography 268 (1983):321-328.
58. H. Okamoto, A. Uetake, R. Tamaya, T. Nakajima, K. Sagara, and Y. Ito, Simultaneous determination of ingredients in an ointment by hydrophobic interaction electrokinetic chromatography. Journal of Chromatography A 929 (2001):133-141.
59. J. M. Calatayud, P. C. Falcó, and A. S. Sanpedro, Turbidimetric determination of chlorhexidine using flow injection analysis. Analyst 112 (1987):87-90.
60. T. Pérez-Ruiz, C.Matínez-Lozano A. Sanz, and A. Sánchez, Flowinjection extraction-spectrophotometric method for the determination of chlorhexidine in pharmaceutical preparations. Journal of Pharmaceutical and Biomedical Analysis 21 (1999):709-714.
61. L.-H. Wang and S.-J. Tsai, Voltametric behavior of chlorhexidine at a film mercury electrodes and its determination in cosmetic and oral hygiene products. Analytica Chimica Acta 441 (2001):107-116.
62. N. J. Medlicott, I. G. Tucker, M. J. Rathbone, D. W. Holborow, and D. S. Jones, Chlorhexidine release from poly(ε-caprolactone) films prepared by solvent evaporation. International Journal of Pharmaceutics 143 (1996):25-35.
63. N. J. Medlicott, D.W. Holborow, M. J. Rathbone, D. S. Jones, and I. G. Tucker, Local delivery of chlorhexidine using a tooth-bonded delivery system. Journal of Controlled Release 61 (1999):337-343.
64. P. Giunchedi, C. Juliano, E. Gavini, M. Cossu, and M. Sorrenti, Formulation and in vivo evaluation of chlorhexidine buccal tablets prepared using drug-loaded chitosan microspheres. European Journal of Pharmaceutics and Biopharmaceutics 53 (2003):233-239.
65. I.C. Yue, J. Poff, M. E. Cortés, R.D. Sinisterra, C. B. Faris, P. Hildgen, R. Langer, and V. P. Shastri, A novel polymeric chlorhexidine delivery device for the treatment of periodontal disease. Biomaterials 25 (2004):3743-3750.
66. G. Palmer, F. H. Jones, R. W. Billington, and G. J. Pearson, Chlorhexidine release from an experimental glass ionomer cement. Biomaterials 25 (2004):5423-5431.
67. B. J. Rasimick, B. S. M. Nekich, B. S. M. M. Hladek, B. S. B. L. Musikant, and A. S. Deutsch. Interaction between chlorhexidine digluconate and EDTA. Basic Research-Technology 34 (2008):1521-1523.
68. E. Farkas, D. Kiss, and R. Zelkó, Study on the release of chlorhexidine base and salts from different liquid crystalline structures. International Journal of Pharmaceutics 340 (2007):71-75.
69. C. Lafforgue, L. Carret, F. Falson, M. E. Reverdy, and J. Freney, Percutaneous absorption of a chlorhexidine digluconate solution. International Journal of Pharmaceutics 147 (1997):243-246.
70. M. J. Souza, R. R. Kulmann, L. M. Silva, D. R. Nogueira, and E. S. Zimmermann, Development and in-house validation of a microbiological assay for determination of cefepime in injectable preparation. Journal of AOAC International 89(5) (2006):1367-1372.