A meta-analysis of potential risks of low levels of protein Z for diseases related to vascular thrombosis

Thrombosis and Haemostasis

Volumn 103, Issue 4, 2010, Pages 749-756

  Sofi, Francesco ^a,b,c   Cesari, Francesca ^a   Abbate, Rosanna ^a   Gensini, Gian Franco ^a,b,c   Broze Jr , George ^d   Fedi, Sandra ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^c CAREGGI UNIVERSITY HOSPITAL   (Italy)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Coagulation; Meta analysis; Protein Z; Thrombosis

Indexed keywords

FATTY ACID BINDING PROTEIN;

ARTERY THROMBOSIS; ARTICLE; CLINICAL TRIAL; DISEASE PREDISPOSITION; HUMAN; INFORMATION PROCESSING; MEDICAL RESEARCH; META ANALYSIS; PREGNANCY COMPLICATION; PRIORITY JOURNAL; RISK FACTOR; SYSTEMATIC REVIEW; VENOUS THROMBOEMBOLISM;

ADULT; BIOLOGICAL MARKERS; BLOOD COAGULATION; BLOOD PROTEINS; DOWN-REGULATION; FEMALE; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; PREGNANCY; PUBLICATION BIAS; RISK ASSESSMENT; RISK FACTORS; THROMBOSIS;

EID: 77952068204     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH09-09-0645     Document Type: Article

References (36)

1. Broze GJ Jr, Miletich JP. Human protein Z. J Clin Invest 1984; 73: 933-938.
2. Ichinose A, Takeya H, Espling E, et al. Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein. Biochem Biophys Res Comm 1990; 172: 1139-1144.
3. Han X, Fiehler R, Broze GJ Jr. Isolation of a protein Z-dependent plasma protease inhibitor. Proc Natl Acad Sci USA 1998; 95: 9250-9255. (Pubitemid 28506217)
4. Vasse M. Protein Z, a protein seeking a pathology. Thromb Haemost 2008; 100: 548-556.
5. Vasse M, Guegan-Massardier E, Borg JY, et al. Frequency of protein Z deficiency in patients with ischaemic stroke. Lancet 2001; 357: 933-934. (Pubitemid 32247286)
6. Kobelt K, Demarmels Biasiutti F, Mattle HP, et al. Protein Z in ischemic stroke. Br J Haematol 2001; 114: 169-173.
7. Gris JC, Quere I, Dechaud E, et al. High frequency of protein Z deficiency in patients with unexplained early fetal loss. Blood 2002; 99: 2606-2608. (Pubitemid 34525453)
8. Kemkes-Matthes B, Nees M, Kunhel G, et al. Protein Z influences the prothrombotic phenotype in factor V Leiden patients. Thromb Res 2002; 106: 183-185. (Pubitemid 35248049)
9. Lopaciuk S, Bykowska K, Kwiecinski H, et al. Protein Z in young survivors of ischemic stroke. Thromb Haemost 2002; 88: 536. (Pubitemid 35021617)
10. Heeb MJ, Paganini-Hill A, Griffin JH, et al. Low protein Z levels and risk of ischemic stroke: differences by diabetic status and gender. Blood Cells Mol Dis 2002; 29: 139-144.
11. Koutroubakis I, Theodoropoulou A, Sfiridaki A, et al. Low plasma protein Z levels in patients with ischemic colitis. Dig Dis Sci 2003; 48: 1673-1676. (Pubitemid 37174713)
12. Fedi S, Sofi F, Brogi D, et al. Low protein Z plasma levels are independently associated with acute coronary syndromes. Thromb Haemost 2003; 90: 1173-1178. (Pubitemid 38004440)
13. McQuillan A, Eikelboom J, Hankey G, et al. Protein Z in ischemic stroke and its etiologic subtypes. Stroke 2003; 34: 2415-2419. (Pubitemid 37221953)
14. Ayoub N, Esposito G, Barete S, et al. Protein Z deficiency in antiphospholipidnegative Sneddon's syndrome. Stroke 2004; 35: 1329-1332. (Pubitemid 38697452)
15. Grandone E, Colaizzo D, Cappucci F, et al. Protein Z levels and unexplained fetal losses. Fertil Steril 2004; 82: 982-983. (Pubitemid 39346459)
16. Morange PE, Juhan-Vague I, on behalf of the PRIME study group. Protein Z plasma levels are not associated with the risk of coronary heart disease: the PRIME study. J Thromb Haemost 2004; 2: 2050-2051. (Pubitemid 40192761)
17. Paidas MJ, Ku DHW, Lee MJ, et al. Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications. J Thromb Haemost 2005; 3: 497-501.
18. Al-Shanqeeti A, van Hylckama Vlieg A, Berntorp E, et al. Protein Z and protein Z-dependent protease inhibitor. Thromb Haemost 2005; 93: 411-413.
19. Sofi F, Cesari F, Vigiani S, et al. Protein Z levels in different phases of activity of coronary atherosclerosis. J Thromb Haemost 2005; 3: 2254-2258. (Pubitemid 41727204)
20. Koren-Michowitz M, Eting E, Rahimi-Levene N, et al. Protein Z levels and central retinal vein or artery occlusion. Eur J Haematol 2005; 75: 401-405. (Pubitemid 41445080)
21. Bretelle F, Arnoux D, Shojai R, et al. Protein Z in patients with pregnancy complications. Am J Obstet Gynecol 2005; 193: 1698-1702.
22. Martinelli I, Razzari C, Biguzzi E, et al. Low levels of protein Z and the risk of venous thromboembolism. J Thromb Haemost 2005; 3: 2817-2819. (Pubitemid 41819816)
23. Santacroce R, Sarno M, Cappucci F, et al. Low protein Z levels and risk of occurrence of deep vein thrombosis. J Thromb Haemost 2006; 4: 2417-2422. (Pubitemid 44590976)
24. Kolaitis NJ, Felekis T, Dova L, et al. A high normal value of plasma protein Z is an uncommon finding in non-arteritic ischemic optic neuropathy (N-AION) patients. J Thromb Haemost 2007; 5 (Suppl 2): P-S-101.
25. Erez O, Hoppensteadt D, Romero R, et al. Preeclampsia is associated with low concentrations of protein Z. J Matern Fetal Neonatal Med 2007; 20: 661-667. (Pubitemid 47262708)
26. Sofi F, Cesari F, Pratesi G, et al. Low protein Z levels in patients with peripheral arterial disease. Thromb Haemost 2007; 89: 1114-1117. (Pubitemid 350091141)
27. Pardos-Gea J, Ordi-Ros J, Serrano S, et al. Protein Z levels and anti-protein Z antibodies in patients with arterial and venous thrombosis. Thromb Res 2008; 121: 727-734. (Pubitemid 351491281)
28. van Goor MPJ, Dippel DWJ, Jie KSG, et al. Low protein Z levels but not the protein Z gene G79A polymorphism are a risk factor for ischemic stroke. Thromb Res 2008; 123: 213-218.
29. Topalidou M, Effraimidou S, Farmakiotis D, et al. Low protein Z levels, but nor the intron F G79A polymorphism, are associated with unexplained pregnancy loss. Thromb Res 2009; 124: 24-27.
30. Grandone E, Favuzzi G, De Stefano V, et al. Protein Z g-42a variant and the risk of pregnancy-related venous thromboembolism in a cohort of Italian patients. Thromb Res 2009; 123: 848-850.
31. Sofi F, Cesari F, Tu Y, et al. Protein Z-dependent protease inhibitor and protein Z in peripheral arterial disease patients. J Thromb Haemost 2009; 7: 731-735.
32. Le Cam-Duchez V, Soria C, Sollier CBD, et al. Rare genotypes of protein Z gene are a risk factor for premature myocardial infarction but not protein Z plasma level. Thromb Haemost 2009; 102: 131-136.
33. Yin ZF, Huang ZF, Cui J, et al. Prothrombotic phenotype of protein Z deficiency. Proc Natl Acad Sci 2000; 97: 6734-6738.
34. Zhang J, Tu Y, Lu L, et al. Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency. Blood 2008; 111: 4973-4978.
35. Greten J, Kreis L, Liliensiek B, et al. Localisation of protein Z in vascular lesions of patients with atherosclerosis. VASA 1998; 27: 144-148. (Pubitemid 28364113)
36. Heeb MJ, Fisher M, Paganini-Hill A. Association of low protein Z levels with ischemic stroke in young women. Thromb Haemost 2007; 97: 495-496. (Pubitemid 46437815)