Low protein Z levels and risk of occurrence of deep vein thrombosis

Journal of Thrombosis and Haemostasis

Volumn 4, Issue 11, 2006, Pages 2417-2422

  Santacroce, R ^a   Sarno, M ^a   Cappucci, F ^a   Sessa, F ^a   Colaizzo, D ^b   Brancaccio, V ^c   Grandone, E ^b   Margaglione, Maurizio ^a,b  

^a UNIVERSITY OF FOGGIA   (Italy)

^b CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^c CARDARELLI HOSPITAL   (Italy)

Author keywords

Deep vein thrombosis; Gene; Polymorphisms; Protein Z

Indexed keywords

ADENINE NUCLEOTIDE; BLOOD CLOTTING FACTOR 5 LEIDEN; FATTY ACID BINDING PROTEIN; GUANINE NUCLEOTIDE; PROTHROMBIN A; PYRIMIDINE NUCLEOTIDE;

ADOLESCENT; ADULT; AGED; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; INCIDENCE; INTRON; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; SEQUENCE ANALYSIS;

ADULT; AGED; BLOOD PROTEINS; FEMALE; HUMANS; INTRONS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; RISK FACTORS; VENOUS THROMBOSIS;

EID: 33750142791     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2006.02186.x     Document Type: Article

References (31)

1. Kniffin WD, Baron JA, Barret J, Birkmeyer JD, Anderson FA Jr. The epidemiology of diagnosed pulmonary embolism and deep venous thrombosis in the elderly. Arch Intern Med 1994; 154: 861-6.
2. De Stefano V, Finazzi G, Mannucci PM. Inherited thrombophilia. Pathogenesis, clinical syndromes and management. Blood 1996; 87: 3531-44.
3. Lane DA, Mannucci PM, Bauer KA, Bertina RM, Bochkov NP, Boulyjenkov V, Chandy M, Dahlback B, Ginter EK, Miletich JP, Rosendaal FR, Seligsohn U. Inherited thrombophilia. Part 1. Thromb Haemost 1996; 76: 651-62.
4. Broze GJ Jr. Protein Z dependent regulation of coagulation. Thromb Haemost 2001; 86: 8-13.
5. Kemkes-Matthes B, Matthes KJ. Protein Z deficiency: A new cause of bleeding tendency. Thromb Res 1995; 79: 49-55.
6. Yin ZF, Huang ZF, Cui J, Fiehler R, Lasky N, Ginsburg D, Broze GJ Jr. Prothrombotic phenotype of protein Z deficiency. Proc Natl Acad Sci USA 2000; 97: 6734-8.
7. Kemkes-Matthes B, Nees M, Kuhnel G, Matzdorff A, Matthes KJ. Protein Z influences prothrombotic phenotype of factor V Leiden in humans. Thromb Res 2002; 106: 183-5.
8. Gris JC, QuéréI, Dechaud H, Mercier E, Pincon C, Hoffet M, Vasse M, Mares P. High frequency of protein Z deficiency in patients with unexplained early fetal loss. Blood 2002; 99: 2606-8.
9. Bretelle F, Arnoux D, Shojai R, D'Ercole C, Sampol J, Dignat F, Camoin-Jau L. Protein Z in patients with pregnancy complications. Am J Obstet Gynecol 2005; 193: 1698-702.
10. Fedi S, Sofi F, Brogi D, Tellini I, Cesari F, Sestini I, Gazzini A, Comeglio M, Abbate R, Gensini GF. Low protein Z plasma levels are independently associated with acute coronary syndromes. Thromb Haemost 2003; 90: 1173-8.
11. Vasse M, Guegan-Massardier E, Borg JY, Woimant F, Soria C. Frequency of protein Z deficiency in patients with ischaemic stroke. Lancet 2001; 357: 933-4.
12. Ravi S, Mauron T, Lämmle B, Wuillemin WA. Protein Z in healthy human individuals and in patients with bleeding tendency. Br J Haematol 1998; 102: 1219-23.
13. Hopmeier P, van Trotsemburg M, Dossenbach-Glanicher A. Recurrent pregnancy loss between the 8th and the 15th week of gestation is not associated with an increased frequency of protein Z deficiency [Abstract]. J Thromb Haemost 2003; 1: P0865.
14. Morange PE, Juhan-Vague I, PRIME Study Group Protein Z plasma levels are not associated with the risk of coronary heart disease: The PRIME Study. J Thromb Haemost 2004; 2: 2050-1.
15. Staton J, Sayer M, Hankey GJ, Cole V, Thom J, Eikelboom JW. Protein Z gene polymorphisms, protein Z concentrations, and ischemic stroke. Stroke 2005; 36: 1123-7.
16. Martinelli I, Razzari C, Biguzzi E, Bucciarelli P, Mannucci PM. Low levels of protein Z and the risk of venous thromboembolism. J Thromb Haemost 2005; 3: 2817-9.
17. Lichy C, Kropp S, Dong-Si T, Genius J, Dolan T, Hampe T, Stoll F, Reuner K, Grond-Ginsbach C, Grau A. A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. Stroke. 2004; 35: 40-5.
18. Santacroce R, Cappucci F, Di Perna P, Sessa F, Margaglione M. Protein Z gene polymorphisms are associated with protein Z plasma levels. J Thromb Haemost 2004; 2: 1197-9.
19. Rice GI, Futers TS, Grant PJ. Identification of novel polymorphisms within the protein Z gene, haplotype distribution and linkage analysis. Thromb Haemost 2001; 85: 1123-4.
20. Kemkes-Matthes B, Souri M, Ichinose A, Matthes KJ. First cases of homozygous combined protein Z- and factor V Leiden mutation in humans [Abstract]. Blood 2000; 96: 74b.
21. Margaglione M, D'Andrea G, D'Addedda M, Giuliani N, Cappucci G, Iannaccone L, Vecchione G, Grandone E, Brancaccio V, Di Minno G. The methylenetetrahydrofolate reductase TT677 genotype is associated with venous thrombosis independently of the coexistence of the FV Leiden and the prothrombin A 20210 mutations. Thromb Haemost 1998; 79: 907-11.
22. Margaglione M, Brancaccio V, Giuliani N, D'Andrea G, Cappucci G, Iannaccone L, Vecchione G, Grandone E, Di Minno G. Increased risk of venous thrombosis in carriers of the prothrombin A 20210 gene variant. Ann Intern Med 1998; 129: 89-93.
23. Koeleman BPC, Reitsma PH, Allart CF, Bertina RM. Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families. Blood 1994; 84: 1031-5.
24. Poort SR, Rosendal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
25. Han X, Fiehler R, Broze GJ Jr. Characterization of the protein Z-dependent protease inhibitor. Blood 2000; 96: 3049-55.
26. McQuillan AM, Eikelboom JW, Hankey GJ, Baker R, Thom J, Staton J, Yi Q, Cole V. Protein Z in ischemic stroke and its etiologic subtypes. Stroke 2003; 34: 2415-9.
27. Miletich JP, Broze GJ Jr. Human plasma protein Z antigen: Range in normal subjects and effects of warfarin therapy. Blood 1987; 69: 1580-6.
28. Al-Shanqueeti A, van Hylckama Vlieg A, Berntorp E, Rosendaal FR, Broze GJ Jr. Protein Z and protein Z-dependent protease inhibitor. Determinants of levels and risk of venous thrombosis. Thromb Haemost 2005; 93: 411-3.
29. NakhléA, Esposito G, Barete S, Soria C, Piette J-C, Francès C. Protein Z deficiency in antiphospholipid-negative Sneddon's syndrome. Stroke. 2004; 35: 1329-32.
30. Heeb MJ, Paganini-Hill A, Griffin JH, Fisher M. Low protein Z levels and risk of ischemic stroke: Differences by diabetic status and gender. Blood Cells Mol Dis 2002; 29: 139-44.
31. Vasse M, Denoyelle C, Legrand E, Vannier JP, Soria C. Weak regulation of protein Z biosynthesis by inflammatory cytokines. Thromb Haemost 2002; 87: 350-1.