Decreased level of recent thymic emigrants in CD4+ and CD8+T cells from CML patients

Journal of Translational Medicine

Volumn 8, Issue , 2010, Pages

  Li, Yangqiu ^a,b   Geng, Suxia ^a,c   Yin, Qingsong ^a   Chen, Shaohua ^a   Yang, Lijian ^a   Wu, Xiuli ^a   Li, Bo ^a   Du, Xin ^c   Schmidt, Christian A ^d   Przybylski, Grzegorz K ^d,e  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

^c GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^d UNIVERSITY OF GREIFSWALD   (Germany)

^e INSTITUTE OF HUMAN GENETICS   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; CIRCULAR DNA; LYMPHOCYTE ANTIGEN RECEPTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHRONIC MYELOID LEUKEMIA; FEMALE; HUMAN; IMMUNE DEFICIENCY; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; CASE CONTROL STUDY; CELL MOTION; GENETICS; IMMUNOLOGY; LYMPHOCYTE COUNT; MIDDLE AGED; PATHOLOGY; THYMUS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; DNA, CIRCULAR; FEMALE; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; THYMUS GLAND; YOUNG ADULT;

EID: 77952064406     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-8-47     Document Type: Article

References (28)

1. Jabbour E, Cortes J, Kantarjian H. Treatment selection after imatinib resistance in chronic myeloid leukemia. Target Oncol 2009, 4:3-10. 10.1007/s11523-008-0100-y, 19343297.
2. Hadden JW. Immunodeficiency and cancer: prospects for correction. Int Immunopharmacol 2003, 3:1061-71. 10.1016/S1567-5769(03)00060-2, 12860163.
3. Costello RT, Rey J, Fauriat C, Gastaut JA, Olive D. New approaches in the immunotherapy of haematological malignancies. Eur J Haematol 2003, 70:333-45. 10.1034/j.1600-0609.2003.00065.x, 12694173.
4. Pannetier C, Even J, Kourilsky P. T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol Today 1995, 16:176-81. 10.1016/0167-5699(95)80117-0, 7734044.
5. De Villartay JP, Hockett RD, Coran D, Korsmeyer SJ, Cohen DI. Deletion of the human T-cell receptor δ-gene by a site specific recombination. Nature 1988, 335:170-4. 10.1038/335170a0, 2842691.
6. Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, Jamieson BD, Zack JA, Picker LJ, Koup RA. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998, 396:690-5. 10.1038/25374, 9872319.
7. Hazenberg MD, Verschuren MC, Hamann D, Miedema F, van Dongen JJ. T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation. J Mol Med 2001, 79:631-40. 10.1007/s001090100271, 11715066.
8. Geenen V, Poulin JF, Dion ML, Martens H, Castermans E, Hansenne I, Moutschen M, Sekaly RP, Cheynier R. Quantification of T cell receptor rearrangement excision circles to estimate thymic function: an important new tool for endocrine-immune physiology. J Endocrinol 2003, 176:305-11. 10.1677/joe.0.1760305, 12630915.
9. Al-Harthi L, Marchett G, Steffens CM, Poulin J, Sekaly R, Landay A. Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA). J Immunol Methods 2000, 237:187-97. 10.1016/S0022-1759(00)00136-8, 10725462.
10. Douek D, Vescio RA, Betts MR, Brenchley JM, Hill BJ, Zhang L, Berenson JR, Collins RH, Koup RA. Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet 2000, 355:1875-81. 10.1016/S0140-6736(00)02293-5, 10866444.
11. Svaldi M, Lanthaler AJ, Dugas M, Lohse P, Pescosta N, Straka C, Mitterer M. T-cell receptor excision circles: a novel prognostic parameter for the outcome of transplantation in multiple myeloma patients. Br J Haematol 2003, 122:795-801. 10.1046/j.1365-2141.2003.04482.x, 12930391.
12. Poulin JF, Sylvestre M, Champagne P, Dion ML, Kettaf N, Dumont A, Lainesse M, Fontaine P, Roy DC, Perreault C, Sékaly RP, Cheynier R. Evidence for adequate thymic function but impaired naive T-cell survival following allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease. Blood 2003, 102:4600-7. 10.1182/blood-2003-05-1428, 12933579.
13. Przybylski GK, Kreuzer KA, Siegert W, Schmidt CA. No recovery of T-cell receptor excision circles (TRECs) after non-myeloablative allogeneic hematopoietic stem cell transplantation is correlated with the onset of GvHD. J Appl Genet 2007, 48:397-404.
14. Poulin JF, Viswanathan MN, Harris JM, Komanduri KV, Wieder E, Ringuette N, Jenkins M, McCune JM, Sékaly RP. Direct evidence for thymic function in adult humans. J Exp Med 1999, 190:479-86. 10.1084/jem.190.4.479, 2195604, 10449519.
15. Li Y, Chen S, Yang L, Yin Q, Geng S, Wu X, Schmidt CA, Przybylski GK. TRAV and TRBV repertoire, clonality and the proliferative history of umbilical cord blood T cells. Transplant Immunol 2007, 18:151-8.
16. Petridou E, Klimentopoulou AE, Moustaki M, Kostrikis LG, Hatzakis A, Trichopoulos D. Recent thymic emigrants and prognosis in T- and B-cell childhood hematopoietic malignancies. Int J Cancer 2002, 101:74-7. 10.1002/ijc.10568, 12209591.
17. Haining WN, Evans J, Seth N, Callaway G, Wucherpfennig K, Nadler L, Guinan E. Rapid T Cell Response to Vaccination Can Occur without Antibody Response in Children Post HSCT. Blood 2004, 104(11):614a.
18. Li Y, Yin Q, Yang L, Chen S, Geng S, Wu X, Zhong L, Schmidt CA, Przybylski GK. Reduced levels of recent thymic emigrants in acute myeloid leukemia patients. Cancer Immunol Immunother 2009, 58:1047-55. 10.1007/s00262-008-0621-3, 19018534.
19. Geng SX, Li YQ, Chen SH, Yang LJ, Yin QS, Wu XL, Zhang XL. Peripheral blood naive T cell level and its T cell receptor Vbeta repertoire usage profile in patients with chronic myelogenous leukemia. Zhonghua Xue Ye Xue Za Zhi 2005, 26:413-6. (Chinese).
20. Kimmig S, Przybylski GK, Schmidt CA, Laurisch K, Mowes B, Radbruch A, Thiel A. Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J Exp Med 2002, 195:789-94. 10.1084/jem.20011756, 2193736, 11901204.
21. Wang L, Zhu K, Zha X, Chen S, Yang L, Chen S, Li Y. Evolution of T-cell clonality in a patient with Ph-negative acute lymphocytic leukemia occurring after interferon and imatinib therapy for Ph-positive chronic myeloid leukemia. J Hematol Oncol 2010, 3:14. 10.1186/1756-8722-3-14, 2859394, 20377918.
22. Rossi E, Matutes E, Morilla R, et al. Zeta chain and CD28 are poorly expressed on T lymphocytes from chronic lymphocytic leukaemia. Leukemia 1996, 10:494-7.
23. Chen S, Yang L, Chen S, Li Y. TCR ζ chain expression in T cells from patients with CML. Hematology 2009, 14:95-100. 10.1179/102453309X385241, 19298721.
24. Farace F, Orlanducci F, Dietrich PY, Gaudin C, Angevin E, Courtier MH, Bayle C, Hercend T, Triebel F. T cell repertoire in patients with B chronic lymphocytic leukemia. Evidence for multiple in vivo T cell clonal expansions. J Immunol 1994, 153:4281-90.
25. Serrano D, Monteiro J, Allen SL, Kolitz J, Schulman P, Lichtman SM, Buchbinder A, Vinciguerra VP, Chiorazzi N, Gregersen PK. Clonal expansion within the CD4+CD57+ and CD8+CD57+ T cell subsets in chronic lymphocytic leukemia. J Immuno 1997, 158:1482-9.
26. Alatrakchi N, Farace F, Frau E, Carde P, Munck JN, Triebel F. T-cell clonal expansion in patients with B-cell lymphoproliferative disorders. J Immunother 1998, 21:363-70. 10.1097/00002371-199809000-00004, 9789198.
27. Li Y. Recent thymic output function in patients with hematological malignancy. Hematology 2005, 10:297-305. 10.1080/10245330500093591, 16085542.
28. Pido-Lopez J, Imami N, Aspinall R. Both age and gender affect thymic output: more recent thymic migrants in females than males as they age. Clin Exp Immunol 2001, 125:409-13. 10.1046/j.1365-2249.2001.01640.x, 1906152, 11531948.