Single administration of di(n-butyl) phthalate delays spermatogenesis in prepubertal rats

Tissue and Cell

Volumn 42, Issue 2, 2010, Pages 129-135

  Alam, Mohammad Shah ^a   Andrina, Bibin Bintang ^a   Tay, Tat Wei ^a   Tsunekawa, Naoki ^a   Kanai, Yoshiakira ^a   Kurohmaru, Masamichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Di(n butyl) phthalate; First wave of spermatogenesis; Prepubertal stage; Sprague Dawley rats; Testis

Indexed keywords

PHTHALIC ACID DIBUTYL ESTER;

ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY; NONHUMAN; PHAGOCYTOSIS; RAT; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATID; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIUM; SPERMATOZOON MATURATION; TESTIS INJURY; TRANSMISSION ELECTRON MICROSCOPY;

RATTUS;

EID: 77952009175     PISSN: 00408166     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tice.2010.02.004     Document Type: Article

References (33)

1. Alam M.S., Ohsako S., Matsuwaki T., Zhu X.B., Tsunekawa N., Kanai Y., Sone H., Tohyama C., Kurohmaru M. Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis: a possible estrogenic effects of di(n-butyl) phthalate. Reproduction 2010, 139:427-437.
2. Autian J. Toxicity and health threats of phthalate esters: review of the literature. Environ. Health Perspect. 1973, 4:3-26.
3. Bartke A. Apoptosis of male germ cells, a generalized or a cell type-specific phenomenon?. Endocrinology 1995, 136:3-4.
4. Boekelheide K. Sertoli cell toxicants. The Sertoli Cell 1993, 551-575. Cache River Press, Florida. L.D. Russell, M. Griswold (Eds.).
5. Clermont Y., Perey B. Quantitative study of the cell population of the seminiferous tubules in immature rats. Am. J. Anat. 1957, 100:241-267.
6. Creasy D.M., Beech L.M., Gray T.J.B., Butler W.H. The ultrastructural effects of di-n-pentyl phthalate on the testis of the mature rat. Exp. Mol. Pathol. 1987, 46:357-371.
7. Dostal L.A., Chapin R.E., Stefanski S.A., Harris M.W., Schwetz B.A. Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl)phthalate and the recovery of fertility as adults. Toxicol. Appl. Pharmacol. 1987, 95:104-121.
8. Dym M. Spermatogonial stem cells of the testis. Proc. Natl. Acad. Sci. 1994, 91:11287-11289.
9. Foster P.M.D., Foster J.R., Cook M.W., Thomas L.V., Gangolli S.D. Changes in ultrastructure and cytochemical localization of zinc in rat testis following the administration of di-n-pentyl phthalate. Toxicol. Appl. Pharmacol. 1982, 63:120-132.
10. Gray T.J., Gangolli S.D. Aspects of the testicular toxicity of phthalate esters. Environ. Health Perspect. 1986, 65:229-235.
11. Gray T.J., Rowland I.R., Foster P.M., Gangolli S.D. Species differences in the testicular toxicity of phthalate esters. Toxicol. Lett. 1982, 11:141-147.
12. Gray T.J.B., Beamand J.A. Effects of some phthalate esters and other testicular toxins on primary cultures of testicular cells. Food Chem. Toxicol. 1984, 22:123-131.
13. Hoppin J.A., Brock J.W., Davis B.J., Baird D.D. Reproducibility of urinary phthalate metabolites in first morning urine samples. Environ. Health Perspect. 2002, 110:515-518.
14. Jaeger R.J., Rubin R.J. Migration of a phthalate ester plasticizer from polyvinyl chloride blood bags into stored human blood and its localization in human tissues. N. Engl. J. Med. 1972, 287:1114-1118.
15. Kleymenova E., Swanson C., Boekelheide K., Gaido K.W. Exposure in utero to di(n-butyl) phthalate alters the vimentin cytoskeleton of fetal rat Sertoli cells and disrupts Sertoli cell-gonocyte contact. Biol. Reprod. 2005, 73:482-490.
16. Kondo T., Shono T., Suita S. Age-specific effect of phthalate ester on testicular development in rats. J. Pediatr. Surg. 2006, 41:1290-1293.
17. Koji T., Hishikawa Y., Ando H., Nakanishi Y., Kobayashi N. Expression of Fas and Fas ligand in normal and ischemia-reperfusion testes: involvement of the Fas system in the induction of germ cell apoptosis in the damaged mouse testis. Biol. Reprod. 2001, 64:946-954.
18. Lake B.G., Phillips J.C., Linnell J.C., Gangolli S.D. The in vitro hydrolysis of some phthalate diesters by hepatic and intestinal preparations from various species. Toxicol. Appl. Pharmacol. 1977, 39:239-248.
19. Lloyd S.C., Foster P.M. Effect of mono-(2-ethylhexyl) phthalate on follicle-stimulating hormone responsiveness of cultured rat Sertoli cells. Toxicol. Appl. Pharmacol. 1988, 95:484-489.
20. Maeda Y., Shiratsuchi A., Namiki M., Nakanishi Y. Inhibition of sperm production in mice by annexin V microinjected into seminiferous tubules: possible etiology of phagocytic clearance of apoptotic spermatogenic cells and male infertility. Cell Death Differ. 2002, 9:742-749.
21. Mentlein R., Butte W. Hydrolysis of phthalate esters by purified rat and human liver carboxylesterases. Biochem. Pharmacol. 1989, 38:3126-3128.
22. Mylchreest E., Cattley R.C., Foster P.M. Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: an antiandrogenic mechanism?. Toxicol. Sci. 1998, 43:47-60.
23. Mylchreest E., Sar M., Wallace D.G., Foster P.M. Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate. Reprod. Toxicol. 2002, 16:19-28.
24. Oishi S. Reversibility of testicular atrophy induced by di(2-ethylhexyl) phthalate in rats. Environ. Res. 1985, 36:160-169.
25. Oishi S., Hiraga K. Testicular atrophy induced by phthalic acid monoesters: effects of zinc and testosterone concentrations. Toxicology 1980, 15:197-202.
26. Orth J.M. Proliferation of Sertoli cells in fetal and postnatal rats: a quantitative autoradiographic study. Anat. Rec. 1982, 203:485-492.
27. Research and Statistics Department Minister's Secretariat Yearbook of Chemical Industries Statistics in 1999 2000, Ministry of International Trade and Industry, Tokyo, pp. 142-145.
28. Tay T.W., Andriana B.B., Ishii M., Choi E.K., Zhu X.B., Alam M.S., Tsunekawa N., Kanai Y., Kurohmaru M. Phagocytosis plays an important role in clearing dead cells caused by mono(2-ethylhexyl) phthalate administration. Tissue Cell 2007, 39:241-246.
29. Tay T.W., Andrina B.B., Ishii M., Tsunekawa N., Kanai Y., Kurohmaru M. Disappearance of vimentin in Sertoli cells: a mono(2-ethylhexyl) phthalate effect. In. J. Toxicol. 2007, 26:289-295.
30. Teirlynck O.A., Kaufman J.M., Bogaert M.G., Roels H. Testicular toxicity induced by single dosing of di- and mono(2ethylhexyl) phthalate in the rat. Toxicol. Lett. 1988, 40:85-91.
31. Tsunekawa N., Matsumoto M., Tone S., Nishida T., Fujimoto H. The HSP70 homolog gene, Hsc 70t, is expressed under translational control during mouse spermatogenesis. Mol. Reprod. Dev. 1999, 52:383-391.
32. Xiong W., Wang H., We H., Chen Y., Han D. Apoptotic spermatogenic cells can be energy sources for Sertoli cells. Reproduction 2009, 137:469-479.
33. Yan W., Suominen J., Samson M., Jegou B., Tappari J. Involvement of Bcl-2 family proteins in germ cell apoptosis during testicular development in the rat and pro-survival effect of stem cell factor on germ cells in vitro. Mol. Cell. Endocrinol. 2000, 165:115-129.