Curvature variation along the tropomyosin molecule

Journal of Structural Biology

Volumn 170, Issue 2, 2010, Pages 307-312

  Li, Xiaochuan ^a,b   Lehman, William ^a   Fischer, Stefan ^b   Holmes, Kenneth C ^c  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

Actin; Coiled coils; Electron microscopy; Molecular dynamics; Tropomyosin

Indexed keywords

ALANINE; ALPHA TROPOMYOSIN;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN STRUCTURE;

ACTINS; ALANINE; AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; TROPOMYOSIN;

EID: 77951975707     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2009.12.017     Document Type: Article

References (22)

1. Brown J.H., Cohen C. Regulation of muscle contraction by tropomyosin and troponin: how structure illuminates function. Adv. Protein Chem. 2005, 71:121-159.
2. Brown J.H., Kim K.H., Jun G., Greenfield N.J., Dominguez R., Volkmann N., Hitchcock-DeGregori S.E., Cohen C. Deciphering the design of the tropomyosin molecule. Proc. Natl. Acad. Sci. USA 2001, 98:8496-8501.
3. Brown J.H., Zhou Z., Reshetnikova L., Robinson H., Yammani R.D., Tobacman L.S., Cohen C. Structure of the mid-region of tropomyosin: bending and binding sites for actin. Proc. Natl. Acad. Sci. USA 2005, 102:18878-18883.
4. Conway J.F., Parry D.A.D. Structural features in the heptad substructure and longer range repeats of two-stranded alpha-fibrous proteins. Int. J. Biol. Macromol. 1990, 12:328-334.
5. Crick F.H.C. The packing of alpha-helices: simple coiled-coils. Acta Crystallogr. 1953, 6:689-697.
6. Holmes K.C., Lehman W. Gestalt-binding of tropomyosin to actin filaments. J. Muscle Res. Cell Motil. 2008, 29:213-219.
7. Holmes K.C., Popp D., Gebhard W., Kabsch W. Atomic model of the actin filament. Nature 1990, 347:44-47.
8. Lehman W., Galińska-Rakoczy A., Hatch V., Tobacman L.S., Craig R. Structural basis for the activation of muscle contraction by troponin and tropomyosin. J. Mol. Biol. 2009, 388:673-681.
9. Lehman W., Hatch V., Korman V., Rosol M., Thomas L., Maytum R., Geeves M.A., Van Eyk J.E., Tobacman L.S., Craig R. Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. J. Mol. Biol. 2000, 302:593-606.
10. Li X.E., Holmes K.C., Lehman W., Jung H., Fischer S. The shape and flexibility of tropomyosin coiled-coils: implications for actin filament assembly and regulation. J. Mol. Biol. 2010, 395:327-339.
11. Lorenz M., Poole K.J.V., Popp D., Rosenbaum G., Holmes K.C. An atomic model of the unregulated thin filament obtained by X-ray fiber diffraction on oriented actin-tropomyosin gels. J. Mol. Biol. 1995, 246:108-119.
12. McLachlan A.D., Stewart M. The 14-fold periodicity in alpha-tropomyosin and the interaction with actin. J. Mol. Biol. 1976, 103:271-298.
13. Nirody, J., Li, X., Sousa, D., Sumida, J., Fischer, S., Lehrer, S., Lehman, W., 2010. Electron microscopy and molecular dynamics on a D137L mutant of tropomyosin. Biophys. J., in press.
14. Nitanai Y., Minakata S., Maéda K., Oda N., Maéda Y. Crystal structures of tropomyosin: flexible coiled-coil. Adv. Exp. Med. Biol. 2007, 592:137-151.
15. Oda T., Iwasa M., Aihara T., Maéda Y., Narita A. The nature of the globular- to fibrous-actin transition. Nature 2009, 457:441-445.
16. Parry D.A.D. Analysis of the primary sequence of alpha-tropomyosin from rabbit skeletal muscle. J. Mol. Biol. 1975, 98:519-535.
17. Pettersen E.F., Goddard T.D., Huang C.C., Couch G.S., Greenblatt D.M., Meng E.C., Ferrin T.E. UCSF Chimera - a visualization system for exploratory research and analysis. J. Comput. Chem. 2004, 25:1605-1612.
18. Phillips G.N., Fillers J.P., Cohen C. Tropomyosin crystal structure and muscle regulation. J. Mol. Biol. 1986, 192:111-131.
19. Singh A., Hitchcock-DeGregori S.E. Local destabilization of the tropomyosin coiled coil gives the molecular flexibility required for actin binding. Biochemistry 2003, 42:14114-14121.
20. Singh A., Hitchcock-DeGregori S.E. Dual requirement for flexibility and specificity for binding of the coiled-coil tropomyosin to its target, actin. Structure 2006, 14:43-50.
21. Stewart M., McLachlan A.D. Fourteen actin-binding sites on tropomyosin?. Nature 1975, 257:331-333.
22. 2-terminal half and complete sequence. J. Biol. Chem. 1978, 253:1137-1148.