Surface functionalization of polyketal microparticles with nitrilotriacetic acid-nickel complexes for efficient protein capture and delivery

Biomaterials

Volumn 31, Issue 18, 2010, Pages 4987-4994

  Sy, Jay C ^a   Phelps, Edward A ^a,b   García, Andrés J ^a,b   Murthy, Niren ^a   Davis, Michael E ^a,c  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Affinity; Drug delivery; Growth factors; Microsphere; Nickel; Surface modification

Indexed keywords

CELL-SPECIFIC LIGANDS; DEGRADABLE POLYMERS; DILUTE SOLUTION; DRUG DELIVERY SYSTEM; ENCAPSULATION EFFICIENCY; GROWTH FACTOR; HIGH AFFINITY; HISTIDINE TAGS; IMMOBILIZED METALS; MICRO-PARTICLES; NICKEL COMPLEX; NICKEL SURFACES; NITRILOTRIACETIC ACID; PROTEIN DELIVERY; PROTEIN DENATURATION; PROTEIN PURIFICATION; SURFACE FUNCTIONALIZATION; SURFACE MODIFICATION; SURFACE-MODIFIED; VE-CADHERIN;

ACIDS; BIOACTIVITY; COMPLEXATION; DRUG DELIVERY; ENCAPSULATION; ENDOTHELIAL CELLS; LIGANDS; METAL REFINING; MICROSPHERES; NICKEL ALLOYS; PEPTIDES; PHOSPHATASES;

NICKEL;

NICKEL COMPLEX; NITRILOTRIACETIC ACID; POLYHISTIDINE TAG; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN PURIFICATION; RAT; SURFACE PROPERTY;

ANIMALS; CELL LINE; ENDOTHELIAL CELLS; GREEN FLUORESCENT PROTEINS; HUMANS; MACROPHAGES; MICE; MICROSPHERES; MITOCHONDRIA; MUSCLE CELLS; NITRILOTRIACETIC ACID; ORGANOMETALLIC COMPOUNDS; PROTEIN BINDING; SURFACE PROPERTIES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77951974200     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.02.063     Document Type: Article

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