Activin B inhibits lipolysis in 3T3-L1 adipocytes

Biochemical and Biophysical Research Communications

Volumn 395, Issue 3, 2010, Pages 373-376

  Magnusson, Björn ^a   Svensson, Per Arne ^a   Carlsson, Lena M S ^a   Sjöholm, Kajsa ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Activin B; Adipocytes; Lipolysis

Indexed keywords

FATTY ACID; GLYCEROL; INHIBIN B; MYELOPID; SMALL INTERFERING RNA; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE;

ADIPOCYTE; ARTICLE; AUTOCRINE EFFECT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; LIPOLYSIS; PARACRINE SIGNALING; PRIORITY JOURNAL;

3T3-L1 CELLS; ACTIVINS; ADIPOCYTES; ANIMALS; FATTY ACIDS, NONESTERIFIED; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GLYCEROL; INHIBIN-BETA SUBUNITS; LIPOLYSIS; MICE; RNA, SMALL INTERFERING; TRIGLYCERIDES;

EID: 77951974054     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.04.022     Document Type: Article

References (25)

1. D.M. de Kretser, M.P. Hedger, K.L. Loveland, D.J. Phillips, Inhibins, activins and follistatin in reproduction. Hum. Reprod. Update 8 (2002) 529-541.
2. Li L., Shen J.J., Bournat J.C., Huang L., Chattopadhyay A., Li Z., Shaw C., Graham B.H., and Brown C.W. Activin signaling: effects on body composition and mitochondrial energy metabolism. Endocrinology 150 (2009) 3521-3529
3. Matzuk M.M., Kumar T.R., Vassalli A., Bickenbach J.R., Roop D.R., Jaenisch R., and Bradley A. Functional analysis of activins during mammalian development. Nature 374 (1995) 354-356
4. Schrewe H., Gendron-Maguire M., Harbison M.L., and Gridley T. Mice homozygous for a null mutation of activin beta B are viable and fertile. Mech. Dev. 47 (1994) 43-51
5. Antenos M., Zhu J., Jetly N.M., and Woodruff T.K. An activin/furin regulatory loop modulates the processing and secretion of inhibin alpha- and betaB-subunit dimers in pituitary gonadotrope cells. J. Biol. Chem. 283 (2008) 33059-33068
6. Gray A.M., and Mason A.J. Requirement for activin A and transforming growth factor - beta 1 pro-regions in homodimer assembly. Science 247 (1990) 1328-1330
7. Luisi S., Florio P., Reis F.M., and Petraglia F. Expression and secretion of activin A: possible physiological and clinical implications. Eur. J. Endocrinol. 145 (2001) 225-236
8. Hashimoto O., Tsuchida K., Ushiro Y., Hosoi Y., Hoshi N., Sugino H., and Hasegawa Y. CDNA cloning and expression of human activin betaE subunit. Mol. Cell. Endocrinol. 194 (2002) 117-122
9. Rodgarkia-Dara C., Vejda S., Erlach N., Losert A., Bursch W., Berger W., Schulte-Hermann R., and Grusch M. The activin axis in liver biology and disease. Mutat. Res. 613 (2006) 123-137
10. Schmitt J., Hotten G., Jenkins N.A., Gilbert D.J., Copeland N.G., Pohl J., and Schrewe H. Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene. Genomics 32 (1996) 358-366
11. Sjöholm K., Palming J., Lystig T.C., Jennische E., Woodruff T.K., Carlsson B., and Carlsson L.M. The expression of inhibin beta B is high in human adipocytes, reduced by weight loss, and correlates to factors implicated in metabolic disease. Biochem. Biophys. Res. Commun. 344 (2006) 1308-1314
12. Carlsson L.M., Jacobson P., Walley A., Froguel P., Sjöstrom L., Svensson P.A., and Sjöholm K. ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease. Biochem. Biophys. Res. Commun. 382 (2009) 309-314
13. Karastergiou K., and Mohamed-Ali V. The autocrine and paracrine roles of adipokines. Mol. Cell. Endocrinol. 318 (2010) 69-78
14. Andersson M., Wettesten M., Boren J., Magnusson A., Sjöberg A., Rustaeus S., and Olofsson S.O. Purification of diacylglycerol:acyltransferase from rat liver to near homogeneity. J. Lipid Res. 35 (1994) 535-545
15. Lobo S., Wiczer B.M., Smith A.J., Hall A.M., and Bernlohr D.A. Fatty acid metabolism in adipocytes: functional analysis of fatty acid transport proteins 1 and 4. J. Lipid Res. 48 (2007) 609-620
16. Ducharme N.A., and Bickel P.E. Lipid droplets in lipogenesis and lipolysis. Endocrinology 149 (2008) 942-949
17. Guilherme A., Virbasius J.V., Puri V., and Czech M.P. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell. Biol. 9 (2008) 367-377
18. Maury E., and Brichard S.M. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol. Cell. Endocrinol. 314 (2010) 1-16
19. Kim S.J., Nian C., and McIntosh C.H. Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes. J. Biol. Chem. 282 (2007) 34139-34147
20. Steppan C.M., Bailey S.T., Bhat S., Brown E.J., Banerjee R.R., Wright C.M., Patel H.R., Ahima R.S., and Lazar M.A. The hormone resistin links obesity to diabetes. Nature 409 (2001) 307-312
21. Hoggard N., Cruickshank M., Moar K.M., Barrett P., Bashir S., and Miller J.D. Inhibin betaB expression in murine adipose tissue and its regulation by leptin, insulin and dexamethasone. J. Mol. Endocrinol. 43 (2009) 171-177
22. Bak B., Carpio L., Kipp J.L., Lamba P., Wang Y., Ge R.S., Hardy M.P., Mayo K.E., and Bernard D.J. Activins regulate 17beta-hydroxysteroid dehydrogenase type I transcription in murine gonadotrope cells. J. Endocrinol. 201 (2009) 89-104
23. Bernard D.J. Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells. Mol. Endocrinol. 18 (2004) 606-623
24. Kershaw E.E., Hamm J.K., Verhagen L.A., Peroni O., Katic M., and Flier J.S. Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin. Diabetes 55 (2006) 148-157
25. Schweiger M., Schreiber R., Haemmerle G., Lass A., Fledelius C., Jacobsen P., Tornqvist H., Zechner R., and Zimmermann R. Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J. Biol. Chem. 281 (2006) 40236-40241