Cyclic tensile stretch modulates osteogenic differentiation of adipose-derived stem cells via the BMP-2 pathway

Archives of Medical Science

Volumn 6, Issue 2, 2010, Pages 152-159

  Yang, Xingmei ^a   Gong, Ping ^b   Lin, Yunfeng ^a   Zhang, Lirong ^c   Li, Xiaoyu ^a   Yuan, Quan ^a   Tan, Zhen ^b   Wang, Yongyue ^b   Man, Yi ^b   Tang, Hua ^b  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c SICHUAN CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Adipose derived stem cells; BMP 2; Mechanical stress; Osteogenesis

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CD34 ANTIGEN; HERMES ANTIGEN; MESSENGER RNA; OSTEOCALCIN; THY 1 ANTIGEN; TRANSCRIPTION FACTOR RUNX2;

ADIPOSE TISSUE CELL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; MALE; MECHANICAL STRESS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STEM CELL; UPREGULATION;

EID: 77951962058     PISSN: 17341922     EISSN: None     Source Type: Journal    
DOI: 10.5114/aoms.2010.13886     Document Type: Article

References (45)

1. Gardner MJ, MC van der Meulen, D Demetrakopoulos, ER Myers, MP Bostrom. In vivo cyclic axial compression affects bone healing in the mouse tibia. Orthop Res 2006; 24: 1679-1686
2. Zaidi M. Skeletal remodeling in health and disease. Nat Med 2007; 13: 791-801.
3. Kaspar D, Seidl W, Neidlinger Wilke C, Beck A, Claes L, Ignatius A. Proliferation of human-derived osteoblast-like cells depends on the cycle number and frequency of uniaxial strain. J Biomech 2002; 35: 873-880 (Pubitemid 34615986)
4. Weyts FA, Bosmans B, Niesing R, van Leeuwen JP, Weinans H. Mechanical control of human osteoblast apoptosis and proliferation in relation to differentiation. Calcified Tissue Int 2003; 72: 505-512 (Pubitemid 36919517)
5. Simmons CA, Matlis S, Thornton AJ, Chen S, Wang CY, Mooney DJ. Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech 2003; 36: 1087-1096 (Pubitemid 36794104)
6. Li YJ, Batra NN, You L, et al. Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. J Orthop Res 2004; 22: 1283-1289 (Pubitemid 39317920)
7. Koike M, Shimokawa H, Kanno Z, Ohya K, Soma K. Effects of mechanical strain on proliferation and differentiation of bone marrow stromal cell line ST2. J Bone Min Metabol 2005; 23: 219-225 (Pubitemid 40603204)
8. Haasper C, Jagodzinski M, Drescher M, et al. Cyclic strain induces FosB and initiates osteogenic differentiation of mesenchymal cells. Exp Toxicol Pathol 2008; 59: 355-363
9. Friedl G, Schmidt H, Rehak I, Kostner G, Schauenstein K, Windhager R. Undifferentiated human mesenchymal stem cells (hMSCs) are highly sensitive to mechanical strain: transcriptionally controlled early osteo-chondrogenic response in vitro. Osteoarthr Cartil 2007; 15: 1293-1300 (Pubitemid 350029038)
10. Riddle RC, Taylor AF, Genetos DC, Donahue HJ. MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation. Am J Physiol Cell Physiol 2006; 290: C776-84.
11. Rhee ST, El-Bassiony L, Buchman SR. Extracellular signal-related kinase and bone morphogenetic protein expression during distraction osteogenesis of the mandible: in vivo evidence of a mechanotransduction mechanism for differentiation and osteogenesis by mesenchymal precursor cells. Plast Reconstr Surg 2006; 117: 2243-2249 (Pubitemid 44324262)
12. Knippenberg M, Helder MN, Doulabi BZ, Semeins CM, Wuisman PI, Klein Nulend J. Adipose tissue-derived mesenchymal stem cells acquire bone cell-like responsiveness to fluid shear stress on osteogenic stimulation. Tiss Eng 2005; 11: 1780-1788 (Pubitemid 43120189)
13. Wall ME, Rachlin A, Otey C, Loboa EG. Human adipose-derived adult stem cells upregulate palladin during osteogenesis and in response to cyclic tensile strain. Am J Physiol Cell Physiol 2007; 293: C1532-8.
14. Tjabringa GS, Vezeridis PS, Zandieh-Doulabi B, Helder MN, Wuisman PI, Klein Nulend J. Polyamines modulate nitric oxide production and COX-2 gene expression in response to mechanical loading in human adipose tissue-derived mesenchymal stem cells. Stem Cells 2006; 24: 2262-2269 (Pubitemid 44527479)
15. Miyazono K, Maeda S, Imamura T. BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk. Cytok Growth Factor Rev 2005; 16: 251-263 (Pubitemid 40910315)
16. Fulford MH. Signal transduction and mechanical stress. www.stke.org/cgi/content/full/sigtrans;2004/249/re12, 2004.
17. Wan M, Cao X. BMP signaling in skeletal development. Biochem Biophys Res Com 2005; 328: 651-657
18. Zuk PA, Zhu M, Mizuno H. Multilineage cells from Human adipose tissue: implications for cell-based therapies. Tissue Eng 2001; 7: 211-228 (Pubitemid 32295155)
19. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002; 13: 4279-4295 (Pubitemid 35471185)
20. Liu J, Liu T, Zhao Z, et al. Early responses of osteoblast-like cells to different mechanical signals through various signaling pathways. Biochem Biophys Res Commun 2006; 348: 1167-1173 (Pubitemid 44233536)
21. Li Y, Song J, Yang P, Zou R, Fan X, Zhao Z. Establishment of a three-dimensional culture and mechanical loading system for skeletal myoblasts. Cell Biol Int 2008; doi:10.1016/j.cellbi.2008.11.002.
22. Owan I, Burr DB, Turner CH, et al. Mechanotransduction in bone: osteoblasts are more responsive to fluid forces than mechanical strain. Am J Physiol 1997; 273: C810-5. (Pubitemid 27422158)
23. Bochev I, Elmadjian G, Kyurkchiev D, et al. Mesenchymal stem cells from human bone marrow or adipose tissue differently modulate mitogen-stimulated B-cell immunoglobulin production in vitro. Cell Biol Int 2008; 32: 384-393
24. de Ugarte DA, Alfonso Z, Zuk PA, et al. Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow. Immunol Lett 2003; 89: 267-270 (Pubitemid 37222456)
25. Nakagami H, Maeda K, Morishita R, et al. Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells. Arterioscler Thromb Vasc Biol 2005; 25: 2542-2547 (Pubitemid 43732276)
26. Lin Y, Jing W, Wu L, et al. Identification of osteo-adipo progenitor cells in fat tissue. Cell Prolifer 2008; 41: 803-812
27. Westbroek I, Ajubi NE, Alblas MJ, et al. Differential stimulation of prostaglandin G/H synthase-2 in osteocytes and other osteogenic cells by pulsating fluid flow. Biochem Biophys Res Commun 2000; 268: 414-419 (Pubitemid 30119637)
28. Jagodzinski M, Drescher M, Zeichen J, et al. Effects of cyclic longitudinal mechanical strain and dexamethasone on osteogenic differentiation of human bone marrow stromal cells. Eur Cell Mater 2004; 7: 35-41. (Pubitemid 39347334)
29. Oedayrajsingh VM, van Ham S, Knippenberg M, et al. Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure. Cytotherapy 2006; 8: 166-177 (Pubitemid 43675203)
30. Wall ME, Bernacki SH, Loboa EG. Effects of serial passaging on the adipogenic and osteogenic differentiation potential of adipose-derived human mesenchymal stem cells. Tissue Eng 2007; 13: 1291-1298 (Pubitemid 46986729)
31. Bi LX, Simmons DJ, Mainous E. Expression of BMP-2 by rat bone marrow stromal cells in culture. Cal Tissue Int 1999; 64: 63-68 (Pubitemid 29024631)
32. Nomura S, Yamamoto TT. Molecular events caused by mechanical stress in bone. Matrix Biol 2000; 19: 91-96 (Pubitemid 30332432)
33. Sato M, Ochi T, Nakase T, et al. Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis. J Bone Min Res 1999; 14: 1084-1095 (Pubitemid 29314051)
34. Susperregui AR, Vinñals F, Ho PW, Gillespie MT, Martin TJ, Ventura F. BMP-2 regulation of PTHrP and osteoclastogenic factors during osteoblast differentiation of C2C12 cells. J Cell Physiol 2008; 216: 144-152
35. Wang D, Christensen K, Chawla K, Xko G, Krehsbach PH, Franceschi RT. Isolation and characterization of MC3T3-EI preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential. J Bone Mineral Res 1999; 14: 893-903. (Pubitemid 29262883)
36. Stanford CM, Morcuende JA, Brand RA. Proliferative and phenotypic responses of bone-like cells to mechanical deformation. J Orthop Res 1995; 13: 664-670
37. Jansen JH, Weyts FA, Westbroek I, et al. Stretch-induced phosphorylation of ERK1/2 depends on differentiation stage of osteoblasts. J Cell Biochem 2004; 93: 542-551 (Pubitemid 44264189)
38. Kaspar D, Seidl W, Neidlinger Wilke C, Ignatius A, Claes L. Dynamic cell stretching increases human osteoblast proliferation and CICP synthesis but decreases osteocalcin synthesis and alkaline phosphatase activity. J Biomech 2000; 33: 45-51.
39. Rath B, Nam J, Knobloch TJ, Lannutti JJ, Agarwal S. Compressive forces induce osteogenic gene expression in calvarial osteoblasts. J Biomech 2008; 41: 1095-1103
40. Frost HM. A 2003 update of bone physiology and Wolff's law for clinicians. Angle Orthodontist 2004; 74: 3-15.
41. Zhang L, Kahn CJ, Chen HQ, Tran N, Wang X. Effect of uniaxial stretching on rat bone mesenchymal stem cell: orientation and expressions of collagen types I and III and tenascin-C. Cell Biol Int 2008; 32: 344-352
42. McGarry JG, Klein Nulend J, Mullender MG, Prendergast PJ. A comparison of strain and fluid shear stress in stimulating bone cell responses - a computational and experimental study. FASEB J 2005; 19: 482-484
43. Jones DB, Nolte H, Ubbers Schol JG, Turner E, Veltel D. Biochemical signal transduction of mechanical strain in osteoblastlike cells. Biomaterials 1991; 12: 101-110
44. Isaksson H, Comas O, van Donkelaar CC, et al. Bone regeneration during distraction osteogenesis: Mechano-regulation by shear strain and fluid velocity. J Biomech 2006; 40: 2002-2011 (Pubitemid 46843004)
45. Kelly DJ, Prendergas PJ. Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects. J Biomech 2005; 38: 1413-1422