The effects of antenatal anticoagulants (low-molecular-weight heparin and aspirin) on neonatal pulmonary vasculature in rabbits

Pediatric and Developmental Pathology

Volumn 13, Issue 2, 2010, Pages 107-111

  Canpolat, Fuat Emre ^a   Orhan, Diclehan ^a   Yigit, Şule ^a   Kale, Gülsev ^a   Yurdakök, Murat ^a   Tekinalp, Gülsevin ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Angiogenesis; Development; Low molecular weight heparin; Lung; Placenta; Vessel

Indexed keywords

ACETYLSALICYLIC ACID; ENOXAPARIN; PLACENTAL GROWTH FACTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL WALL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HISTOLOGY; LUNG ALVEOLUS; LUNG BLOOD VESSEL; MICROVASCULATURE; NONHUMAN; PRENATAL PERIOD; PRIORITY JOURNAL; RABBIT;

ANIMALS; ANIMALS, NEWBORN; ANTICOAGULANTS; ASPIRIN; BLOOD VESSELS; FEMALE; HEPARIN, LOW-MOLECULAR-WEIGHT; LUNG; NEOVASCULARIZATION, PHYSIOLOGIC; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RABBITS;

EID: 77951950556     PISSN: 10935266     EISSN: 16155742     Source Type: Journal    
DOI: 10.2350/09-04-0643-OA.1     Document Type: Article

References (31)

1. Greer I, Hunt BJ. Low molecular weight heparin in pregnancy: current issues. Br J Haematol 2005;128:593-601. (Pubitemid 40343227)
2. Duhl AJ, Paidas MJ, Ural SH, et al. Antithrombotic therapy and pregnancy: consensus report and recommendations for prevention and treatment of venous thromboembolism and adverse pregnancy outcome. Am J Obstet Gynecol 2007;197:457.e1-457.e21.
3. Martinelli I, Taioli E, Cetin I, et al. Mutations in coagulation factors in women with unexplained late fetal loss. N Engl J Med 2000;343: 1015-1018.
4. Hefler L, Jirecek S, Heim K, et al. Genetic polymorphisms associated with thrombophilia and vascular disease in women with unexplained late intrauterine fetal death: a multicenter study. J Soc Gynecol Invest 2004;11:42-44. (Pubitemid 38050190)
5. Many A, Elad R, Yaron Y, Eldor A, Lessing JB, Kupferminc MJ. Third-trimester unexplained intrauterine fetal death is associated with inherited thrombophilia. Obstet Gynecol 2002;99:684-687. (Pubitemid 34442440)
6. Gris JC, Quere I, Monpeyroux F, et al. Case-control study of the frequency of thrombophilic disorders in couples with late foetal loss and no thrombotic antecedent: the Nimes Obstetricians and Haematologists Study 5 (NOHA5). Thromb Haemost 1999;81: 891-899.
7. Tarim E, Bal N, Kilicdag E, Kayaselcuk F, Baǧiş T, Kuscu E. Effects of aspirin on placenta and perinatal outcomes in patients with poor obstetric history. Arch Gynecol Obstet 2006;274:209-214. (Pubitemid 43962166)
8. Duley L, Henderson-Smart D, Knight M, King J. Antiplatelet drugs for prevention of pre-eclampsia and its consequences: systematic review. Br Med J 2001;322:329-333. (Pubitemid 32150730)
9. Sergio F, Maria Clara D, Gabriella F, Giorgia S, Sara De Carolis, Giancarlo P, Alessandro C. Prophylaxis of recurrent preeclampsia: low-molecular-weight heparin plus low-dose aspirin versus low-dose aspirin alone. Hypertens Pregnancy 2006;25:115-127. (Pubitemid 44180352)
10. Lepereq J, Conard J, Borel-Derlon A, et al. Venous thromboembolism during pregnancy: a retrospective study of enoxaparin safety in 624 pregnancies. Br J Obstet Gynaecol 2001;108:1134-1140.
11. Sanson BJ, Lensing AWA, Prins MH, et al. Safety of low-molecular-weight heparin in pregnancy: a systemic review. Thromb Haemost 1999;81:668-672.
12. Ginsberg JS, Kowalchuk G, Hirsh J et al. Heparin therapy during pregnancy: risks to the fetus and mother. Arch Intern Med 1989;149: 2233-2236. (Pubitemid 19258167)
13. Rudolph AM. Effects of aspirin and acetaminophen in pregnancy and in the newborn. Arch Intern Med 1981;23:358-363.
14. O'Blenes SB, Merklinger SL, Jegatheeswaran A, Campbell A, Rabinovitch M, Rebeyka I, Van Arsdell G. Low molecular weight heparin and unfractionated heparin are both effective at accelerating pulmonary vascular maturation in neonatal rabbits. Circulation 2003;9(suppl 1):II161-II166.
15. Kovar J, Willet KE, Hislop A, Sly PD. Impact of postnatal glucocorticoids on early lung development. J Appl Physiol 2005;98:881-888.
16. Roubliova XI, Lewi PJ, Vaast P, et al. Effects of betamethasone on peripheral arterial development in term fetal rabbit. Pediatr Pulmonol 2008;43:795-805.
17. Canoǧlu A, Göǧüş C, Bedük Y, Orhan D, Tulunay O, Baltaci S. Microvessel density as a prognostic marker in bladder carcinoma: correlation with tumor grade, stage and prognosis. Int Urol Nephrol 2004;36:401-405.
18. Roubliova XI, Van der Biest AM, Vaast P, et al. Effect of maternal administration of betamethasone on peripheral arterial development in fetal rabbit lungs. Neonatology 2008;93:64-72.
19. Carroll SM, White FC, Roth DM, Bloor CM. Heparin accelerates coronary collateral development in a porcine model of coronary artery occlusion. Circulation 1993;88:198-207.
20. Rakusan K, Turek Z. Protamine inhibits capillary formation in growing rat hearts. Circ Res 1985;57:393-398.
21. Skaletz-Rorowski A, Schmidt A, Breithardt G, Buddecke E. Heparin-induced overexpression of basic fibroblast growth factor, basic fibroblast growth factor receptor, and cell-associated proteo-heparan sulfate in cultured coronary smooth muscle cells. Arterioscler Thromb Vasc Biol 1996;16:1063-1069.
22. Moscatelli D. Metabolism of receptor-bound and matrix-bound basic fibroblast growth factor by bovine capillary endothelial cells. J Cell Biol 1988;107:753-759.
23. Yayon A, Klagsbrun M, Esko JD, Leder P, Ornitz DM. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 1991;64: 841-848.
24. Passaniti A, Taylor RM, Pili R, et al. A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab Invest 1992;67:519-528.
25. Norrby K. Heparin and angiogenesis: a low-molecular-weight fraction inhibits and a high-molecular-weight fraction stimulates angiogenesis systemically. Haemostasis 1993;23(suppl 1):141-149.
26. Lepri A, Benelli U, Bernardini N, et al. Effect of low molecular weight heparan sulphate on angiogenesis in the rat cornea after chemical cauterization. J Ocul Pharmacol 1994;10:273-280.
27. Reynolds LP, Redmer DA. Utero-placental vascular development and placental function. J Anim Sci 1995;73:1839-1851.
28. Reynolds LP, Redmer DA. Angiogenesis in the placenta. Biol Reprod 2001;64:1033-1040.
29. Mamluk R, Gechtman Z, Kutcher ME, Gasiunas N, Gallagher J, Klagsbrun M. Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain. J Biol Chem 2002;277:24818-24825.
30. Quenby S, Mountfield S, Cartwright JE, Whitley GS, Vince G. Effects of low-molecular-weight and unfractionated heparin on trophoblast function. Obstet Gynecol 2004;104:354-361.
31. Watanabe S, Suzuki T, Shizawa S, Endoh M, Tabayashi K, Sasano H. Heparin accelerates pulmonary artery development in neonate rabbits. Tohoku J Exp Med 2005;207:171-179.