Metabolomic differences in heart failure patients with and without major depression

Journal of Geriatric Psychiatry and Neurology

Volumn 23, Issue 2, 2010, Pages 138-146

  Steffens, David C ^a   Wei Jiang, ^a   Krishnan, K Ranga R ^a   Karoly, Edward D ^b   Mitchell, Matthew W ^b   O'Connor, Christopher M ^a   Kaddurah Daouk, Rima ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b METABOLON INC   (United States)

Author keywords

Depression; Heart failure; Metabolomics

Indexed keywords

3 HYDROXYBUTYRIC ACID; ALIPHATIC DICARBOXYLIC ACID; AMINO ACID; ASPARTIC ACID; GAMMA GLUTAMYLGLUTAMINE; GAMMA GLUTAMYLLEUCINE; KETONE BODY; PHENYLALANINE; PLACEBO; SERINE; SERTRALINE; UNCLASSIFIED DRUG;

ADULT; AMINO ACID METABOLISM; ARTICLE; BIOCHEMICAL COMPOSITION; BIOSYNTHESIS; BLOOD SAMPLING; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HEART FAILURE; HUMAN; LIPID METABOLISM; LIQUID CHROMATOGRAPHY; MAJOR DEPRESSION; MALE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLOMICS; NEUROTRANSMITTER UPTAKE; PRIORITY JOURNAL;

DEPRESSIVE DISORDER, MAJOR; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; HEART FAILURE; HUMANS; MALE; METABOLOMICS; MIDDLE AGED; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 77951949967     PISSN: 08919887     EISSN: 15525708     Source Type: Journal    
DOI: 10.1177/0891988709358592     Document Type: Article

References (38)

1. Kaddurah-Daouk R., Kristal BS, Weinshilboum RM Metabolomics: a global biochemical approach to drug response and disease. Ann Rev Pharmacol Toxicol. 2008 ; 48: 653-683. (Pubitemid 351738167)
2. Kristal BS, Shurubor YI, Kaddurah-Daouk R., Matson WR High-performance liquid chromatography separations coupled with coulometric electrode array detectors: a unique approach to metabolomics. Methods Mol Biol. 2007 ; 358: 159-174.
3. Lindon JC, Holmes E., Nicholson JK Metabonomics in pharmaceutical R&D. FEBS J. 2007 ; 274 (5). 1140-1151.
4. Harrigan G., Goodacre R. Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis. Boston: Kluwer Acad Publ ; 2003.
5. Kaddurah-Daouk R., Krishnan KRR. Metabolomics: a global biochemical approach to the study of central nervous system diseases. Neuropsychopharmacol Rev. 2009 ; 34: 173-186.
6. Delgado PL, Moreno FA Role of norepinephrine in depression. J Clin Psychiatr. 2000 ; 61 (Suppl 1). 5-12.
7. Brambilla P., Perez J., Barale F., Schettini G., Soares JC GABAergic dysfunction in mood disorders. Mol Psychiatr. 2003 ; 8 (8). 721-737. (Pubitemid 36976430)
8. Sanacora G., Saricicek A. GABAergic contributions to the pathophysiology of depression and the mechanism of antidepressant action. CNS & Neurological Disorders-Drug Targets. 2007 ; 6 (2). 127-140. (Pubitemid 46681773)
9. Levine J., Panchalingam K., Rapoport A., Gershon S., McClure RJ, Pettegrew JW Increased cerebrospinal fluid glutamine levels in depressed patients. Biol Psychiatr. 2000 ; 47 (7). 586-593. (Pubitemid 30169251)
10. Frye MA, Tsai GE, Huggins T., Coyle JT, Post RM Low cerebrospinal fluid glutamate and glycine in refractory affective disorder. Biol Psychiatr. 2007 ; 61 (2). 162-166. (Pubitemid 46072777)
11. Paige LA, Mitchell MW, Krishnan KR, Kaddurah-Daouk R., Steffens DC A preliminary metabolomic analysis of older adults with and without depression. Int J Geriatr Psychiatr. 2007 ; 22 (5). 418-423. (Pubitemid 46831684)
12. Appleton KM, Rogers PJ, Ness AR Is there a role for n-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials. Nutr Res Rev. 2008 ; 21 (1). 13-41.
13. Beck AT, Steer RA, Ball R., Ranieri W. Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients. J Pers Assess. 1996 ; 67 (3). 588-597. (Pubitemid 26382973)
14. Lawton KA, Berger A., Mitchell M., et al. Analysis of the adult human plasma metabolome. Pharmacogenomics. 2008 ; 9 (4). 383-397. (Pubitemid 351803924)
15. Breiman L. Random forests. Mach Learn. 2001 ; 45: 5-32. (Pubitemid 32933532)
16. Liaw A., Wiener M. Classification and regression by random forest. R News. 2002 ; 2: 18-22.
17. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci U S A. 2003 ; 100: 9440-9445. (Pubitemid 37033947)
18. Benjamini Y., Hochberg Y. Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Roy Statist Soc Ser B (Methodological). 1995 ; 57: 289-300.
19. Muth A., Jung J., Bilke S., et al. Simultaneous enantioselective analysis of chiral urinary metabolites in patients with Zellweger syndrome. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 ; 792 (2). 269-277. (Pubitemid 36830876)
20. Maes M., Verkerk R., Vandoolaeghe E., Lin A., Scharpe S. Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment-resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity. Acta Psychiatr Scand. 1998 ; 97 (4). 302-308. (Pubitemid 28179268)
21. Altamura C., Maes M., Dai J., Meltzer HY Plasma concentrations of excitatory amino acids, serine, glycine, taurine and histidine in major depression. Eur Neuropsychopharmacol. 1995 ; 5 Suppl: 71-75. (Pubitemid 26017262)
22. Stephenson FA Structure and trafficking of NMDA and GABAA receptors. Biochem Soc Transact. 2006 ; 34 (Pt 5). 877-881.
23. Francis PT, Poynton A., Lowe SL, et al. Brain amino acid concentrations and Ca2+-dependent release in intractable depression assessed antemortem. Brain Res. 1989 ; 494 (2). 315-324. (Pubitemid 19194545)
24. Meldrum BS Drugs acting on amino acid neurotransmitters. Adv Neurol. 1986 ; 43: 687-706.
25. Choudry HA, Pan M., Karinch AM, Souba WW Branched-chain amino acid-enriched nutritional support in surgical and cancer patients. J Nutr. 2006 ; 136: 314S - 318S. (Pubitemid 43156531)
26. Murin R., Hamprecht B. Metabolic and regulatory roles of leucine in neural cells. Neurochemical Research. 2008 ; 33 (2). 279-284.
27. Forman HJ, Zhang H., Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. (IN PRESS).
28. Draye JP, Veitch K., Vamecq J., Van Hoof F. Comparison of the metabolism of dodecanedioic acid in vivo in control, riboflavin-deficient and clofibrate-treated rats. Eur J Biochem. 1988 ; 178 (1). 183-189. (Pubitemid 19010197)
29. Mortensen PB C6-C10-dicarboxylic acids in liver and kidney tissue in normal, diabetic ketotic and clofibrate-treated rats. Biochimica et Biophysica Acta. 1986 ; 878 (1). 14-19.
30. Mingrone G., Castagneto M. Medium-chain, even-numbered dicarboxylic acids as novel energy substrates: an update. Nutrition Reviews. Oct 2006 ; 64 (10 Pt 1). 449-456. (Pubitemid 44582076)
31. Rozen S., Cudkowicz ME, Bogdanov M., et al. Metabolomic analysis and signatures in motor neuron disease. Metabolomics. 2005 ; 1 (2). 101-108. (Pubitemid 40778831)
32. Kaddurah-Daouk R. Metabolic profiling of patients with schizophrenia. PLoS Med. Aug 2006 ; 3 (8). e363. (Pubitemid 44338356)
33. Sabatine MS, Liu E., Morrow DA, et al. Metabolomic identification of novel biomarkers of myocardial ischemia. Circulation. 2005 ; 112 (25). 3868-3875.
34. Yang C., Richardson AD, Smith JW, Osterman A. Comparative metabolomics of breast cancer. Pac Symp Biocomput. 2007: 181-192.
35. Yan SK, Wei BJ, Lin ZY, Yang Y., Zhou ZT, Zhang WD A metabonomic approach to the diagnosis of oral squamous cell carcinoma, oral lichen planus and oral leukoplakia. Oral Oncol. 2008 ; 44 (5). 477-483. (Pubitemid 351608618)
36. Kaddurah-Daouk R., McEvoy J., Baillie RA, et al. Metabolomic mapping of atypical antipsychotic effects in schizophrenia. Molecular Psychiatry. 2007 ; 12 (10). 934-945. (Pubitemid 47482696)
37. Parissis JT, Nikolaou M., Farmakis D., et al. Self-assessment of health status is associated with inflammatory activation and predicts long-term outcomes in chronic heart failure. Eur J Heart Failure. 2009 ; 11 (2). 163-169.
38. Parissis JT, Farmakis D., Nikolaou M., et al. Plasma B-type natriuretic peptide and anti-inflammatory cytokine interleukin-10 levels predict adverse clinical outcome in chronic heart failure patients with depressive symptoms: a 1-year follow-up study. Eur J Heart Failure. 2009 ; 11 (10). 967-972.