"Massive" fetal thrombotic vasculopathy associated with excessively long umbilical cord and fetal demise: Case report and literature review

Pediatric and Developmental Pathology

Volumn 13, Issue 2, 2010, Pages 112-115

  Taweevisit, Mana ^a   Thorner, Paul Scott ^a,b  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Fetal thrombotic vasculopathy; Long umbilical cord; Stillbirth

Indexed keywords

ADULT; ARTICLE; CASE REPORT; ECHOGRAPHY; EXCESSIVELY LONG UMBILICAL CORD; FEMALE; FETUS WEIGHT; HUMAN; LABORATORY TEST; MICROSCOPY; PLACENTA WEIGHT; PRIORITY JOURNAL; THROMBOSIS; UMBILICAL MALFORMATION; VAGINAL DELIVERY; VASCULAR DISEASE;

FEMALE; FETAL DEATH; FETAL DISEASES; HUMANS; MALE; PLACENTA DISEASES; PREGNANCY; STILLBIRTH; THROMBOSIS; UMBILICAL CORD;

EID: 77951943475     PISSN: 10935266     EISSN: 16155742     Source Type: Journal    
DOI: 10.2350/09-07-0680-CR.1     Document Type: Article

References (19)

1. Baergen RN. Cord abnormalities, structural lesions, and cord "accidents." Semin Diagn Pathol 2007;24:23-32.
2. Dursun P, Salman MC, Ozyuncu O, Aksu T. Nuchal cord type B associated with an excessively long umbilical cord as a cause of stillbirth: a case report. Clin Exp Obstet Gynecol 2004;31:158-159.
3. Benirschke K. Obstetrically important lesions of the umbilical cord. J Reprod Med 1994;39:262-272.
4. Baergen RN, Malicki D, Behling C, Benirschke K. Morbidity, mortality, and placental pathology in excessively long umbilical cords: retrospective study. Pediatr Dev Pathol 2001;4:144-153.
5. Parast MM, Crum CP, Boyd TK. Placental histologic criteria for umbilical blood flow restriction in unexplained stillbirth. Hum Pathol 2008;39:948-953.
6. Redline RW, Pappin A. Fetal thrombotic vasculopathy: the clinical significance of extensive avascular villi. Hum Pathol 1995;26:80-85.
7. Redline RW. Clinical and pathological umbilical cord abnormalities in fetal thrombotic vasculopathy. Hum Pathol 2004;35:1494-1498.
8. Vern TZ, Alles AJ, Kowal-Vern A, Longtine J, Roberts DJ. Frequency of factor V(Leiden) and prothrombin G20210A in placentas and their relationship with placental lesions. Hum Pathol 2000;31:1036-1043.
9. Redline RW, Ariel I, Baergen RN, et al. Fetal vascular obstructive lesions: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol 2004;7:443-452. (Pubitemid 40385234)
10. Kraus FT, Redline RW, Gersell DJ, Nelson DM, Dicke JM. Fetal circulation: thrombi and hematomas. In: Kraus FT, Redline RW, Gersell DJ, Nelson DM, Dicke JM, eds. Placental Pathology. Washington, DC: American Registry of Pathology, 2004;141-151.
11. Redline RW, O'Riordan MA. Placental lesions associated with cerebral palsy and neurologic impairment following term birth. Arch Pathol Lab Med 2000;124:1785-1791.
12. Khong TY, Hague WM. Biparental contribution to fetal thrombophilia in discordant twin intrauterine growth restriction. Am J Obstet Gynecol 2001;185:244-245.
13. Kraus FT, Acheen VI. Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies, and cerebral palsy. Hum Pathol 1999;30:759-769.
14. Dahms BB, Boyd T, Redline RW. Severe perinatal liver disease associated with fetal thrombotic vasculopathy. Pediatr Dev Pathol 2002;5:80-85. (Pubitemid 34279701)
15. Genest DR, Singer DB. Estimating the time of death in stillborn fetuses: III. External fetal examination; a study of 86 stillborns. Obstet Gynecol 1992;80:593-600.
16. Genest DR, Williams MA, Greene MF. Estimating the time of death in stillborn fetuses: I. Histologic evaluation of fetal organs; an autopsy study of 150 stillborns. Obstet Gynecol 1992;80:575-584.
17. Genest DR. Estimating the time of death in stillborn fetuses: II. Histologic evaluation of the placenta; a study of 71 stillborns. Obstet Gynecol 1992;80:585-592.
18. Fox H, Sebire N. Lesions due to disturbances of fetal blood flow. In: Fox H, Sebire N, eds. Pathology of the Placenta, 3rd ed. Philadelphia: Elsevier Saunders, 2007;111-116.
19. Ariel I, Anteby E, Hamani Y, Redline RW. Placental pathology in fetal thrombophilia. Hum Pathol 2004;35:729-733.