Association of ion-channel genotype and macrocyclic lactone sensitivity traits in Haemonchus contortus

Molecular and Biochemical Parasitology

Volumn 171, Issue 2, 2010, Pages 74-80

  Beech, Robin ^a   Levitt, Nancy ^b   Cambos, Mathieu ^c   Zhou, Shufeng ^d   Forrester, Sean G ^e  

^a MCGILL UNIVERSITY   (Canada)

^b Izun Pharma Ltd   (Israel)

^c UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^d MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^e UNIVERSITY OF ONTARIO INSTITUTE OF TECHNOLOGY   (Canada)

Author keywords

Adult feeding; Anthelmintic resistance; Genotype; Haemonchus contortus; Ivermectin; Larval motility; Moxidectin

Indexed keywords

GLC 5 PROTEIN; ION CHANNEL; LGC 37 PROTEIN; MACROLIDE; UNCLASSIFIED DRUG;

ALLELE; ANTIBIOTIC RESISTANCE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SENSITIVITY; DRUG TARGETING; FEEDING BEHAVIOR; FEMALE; GENETIC ASSOCIATION; GENETIC TRAIT; GENOTYPE; HAEMONCHUS CONTORTUS; IN VIVO STUDY; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE DEVELOPMENT; PRIORITY JOURNAL;

ANIMALS; ANTHELMINTICS; DNA, HELMINTH; DRUG RESISTANCE; FEEDING BEHAVIOR; GENOTYPE; HAEMONCHUS; HELMINTH PROTEINS; ION CHANNELS; IVERMECTIN; LACTONES; LARVA; LOCOMOTION; MACROLIDES; MOLECULAR SEQUENCE DATA; SEQUENCE ANALYSIS, DNA; SHEEP;

HAEMONCHUS CONTORTUS; OVIS ARIES; STRONGYLIDA;

EID: 77951938632     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2010.02.004     Document Type: Article

References (38)

1. McKellar Q.A., Benchaoui H.A. Avermectins and milbemycins. Journal of Veterinary Pharmacology and Therapeutics 1996, 19:331-351.
2. Jackson F., Coop R.L. The development of anthelmintic resistance in sheep nematodes. Parasitology 2000, 120:S95-107.
3. Pomroy W.E. Anthelmintic resistance in New Zealand: a perspective on recent findings and options for the future. New Zealand Veterinary Journal 2006, 54:265-270.
4. Beech RN, Wolstenholme AJ, Neveu C, et al. Naming genes in the parasitic nematodes. Trend Parasitol; accepted for publication.
5. Geary T.G., Sims S.M., Thomas E.M., et al. Haemonchus contortus: ivermectin-induced paralysis of the pharynx. Experimental Parasitology 1993, 77:88-96.
6. Blackhall W.J., Prichard R.K., Beech R.N. Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. Molecular and Biochemical Parasitology 2003, 131:137-145.
7. Feng X.P., Hayashi J., Beech R.N., et al. Study of the nematode putative GABA type-A receptor subunits: evidence for modulation by ivermectin. Journal of Neurochemistry 2002, 83:870-878.
8. McCavera S., Rogers A.T., Yates D.M., et al. An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus. Molecular Pharmacology 2009, 75:1347-1355.
9. Blackhall W.J., Pouliot J.F., Prichard R.K., et al. Haemonchus contortus: selection at a glutamate-gated chloride channel gene in ivermectin- and moxidectin-selected strains. Experimental Parasitology 1998, 90:42-48.
10. Liu J., Dent J.A., Beech R.N., et al. Genomic organization of an avermectin receptor subunit from Haemonchus contortus and expression of its putative promoter region in Caenorhabditis elegans. Molecular and Biochemical Parasitology 2004, 134:267-274.
11. Forrester S.G., Hamdan F.F., Prichard R.K., et al. Cloning, sequencing, and developmental expression levels of a novel glutamate-gated chloride channel homologue in the parasitic nematode Haemonchus contortus. Biochemical Biophysical Research Communications 1999, 254:529-534.
12. Portillo V., Jagannathan S., Wolstenholme A.J. Distribution of glutamate-gated chloride channel subunits in the parasitic nematode Haemonchus contortus. Journal of Comparative Neurobiology 2003, 462:213-222.
13. Skinner T.M., Bascal Z.A., Holden-Dye L., et al. Immunocytochemical localization of a putative inhibitory amino acid receptor subunit in the parasitic nematodes Haemonchus contortus and Ascaris suum. Parasitology 1998, 117:89-96.
14. Forrester S.G., Prichard R.K., Dent J.A., et al. Haemonchus contortus: HcGluCla expressed in Xenopus oocytes forms a glutamate-gated ion channel that is activated by ibotenate and the antiparasitic drug ivermectin. Molecular and Biochemical Parasitology 2003, 129:115-121.
15. Njue A.I., Hayashi J., Kinne L., et al. Mutations in the extracellular domains of glutamate-gated chloride channel alpha3 and beta subunits from ivermectin-resistant Cooperia oncophora affect agonist sensitivity. Journal of Neurochemistry 2004, 89:1137-1147.
16. Anderson T.J., Blouin M.S., Beech R.N. Population biology of parasitic nematodes: applications of genetic markers. Advances in Parasitology 1998, 41:219-283.
17. Gilleard J.S., Beech R.N. Population genetics of anthelmintic resistance in parasitic nematodes. Parasitology 2007, 134:1133-1147.
18. Blackhall W.J., Liu H.Y., Xu M., et al. Selection at a P-glycoprotein gene in ivermectin- and moxidectin-selected strains of Haemonchus contortus. Molecular and Biochemical Parasitology 1998, 95:193-201.
19. Eng J.K., Blackhall W.J., Osei-Atweneboana M.Y., et al. Ivermectin selection on beta-tubulin: evidence in Onchocerca volvulus and Haemonchus contortus. Molecular and Biochemical Parasitology 2006, 150:229-235.
20. Beech RN, Silvestre A. Mutations associated with anthelmintic drug resistance. Anti-Infective Agents in Medicinal Chemistry; submitted for publication.
21. Molento M.B., Wang G.T., Prichard R.K. Decreased ivermectin and moxidectin sensitivity in Haemonchus contortus selected with moxidectin over 14 generations. Veterinary Parasitology 1999, 86:77-81.
22. Wooster M.J., Woodgate R.G., Chick B.F. Reduced efficacy of ivermectin, abamectin and moxidectin against field isolates of Haemonchus contortus. Australian Veterinary Journal 2001, 79:840-842.
23. Paiement J.P., Leger C., Ribeiro P., et al. Haemonchus contortus: effects of glutamate, ivermectin, and moxidectin on inulin uptake activity in unselected and ivermectin-selected adults. Experimental Parasitology 1999, 92:193-198.
24. Beech R.N., Prichard R.K., Scott M.E. Genetic variability of the beta-tubulin genes in benzimidazole-susceptible and -resistant strains of Haemonchus contortus. Genetics 1994, 138:103-110.
25. Lowry O.H., Rosebrough N.J., Farr A.L., et al. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951, 193:265-275.
26. Gill J.H., Redwin J.M., van Wyk J.A., et al. Detection of resistance to ivermectin in Haemonchus contortus. International Journal for Parasitology 1991, 21:771-776.
27. Forrester S.G., Prichard R.K., Beech R.N. A glutamate-gated chloride channel subunit from Haemonchus contortus: expression in a mammalian cell line, ligand binding, and modulation of anthelmintic binding by glutamate. Biochemical Pharmacology 2002, 63:1061-1068.
28. Laughton D.L., Amar M., Thomas P., et al. Cloning of a putative inhibitory amino acid receptor subunit from the parasitic nematode Haemonchus contortus. Receptors and Channels 1994, 2:155-163.
29. Xu M., Molento M., Blackhall W., et al. Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog. Molecular and Biochemical Parasitology 1998, 91:327-335.
30. Ronaghi M., Uhlen M., Nyren P. A sequencing method based on real-time pyrophosphate. Science 1998, 281:363-365.
31. Agresti A., Coull B. Approximate is better than exact for interval estimation of binomial proportions. The American Statistician 1998, 52:119-126.
32. Ishikawa T., Zhu B.L., Maeda H. Effect of sodium azide on the metabolic activity of cultured fetal cells. Toxicology and Industrial Health 2006, 22:337-341.
33. Gill J.H., Redwin J.M., van Wyk J.A., et al. Avermectin inhibition of larval development in Haemonchus contortus-effects of ivermectin resistance. International Journal for Parasitology 1995, 25:463-470.
34. Dent J.A., Smith M.M., Vassilatis D.K., et al. The genetics of ivermectin resistance in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:2674-2679.
35. Kwa M.S.G., Jetty V.S., Roos M.H. Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino acid 200 in ß-tubulin isotype 1. Molecular and Biochemical Parasitology 1994, 63:299-303.
36. Silvestre A., Cabaret J. Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzimidazole resistance?. Molecular and Biochemical Parasitology 2002, 120:297-300.
37. Rao V.T., Siddiqui S.Z., Prichard R.K., et al. A dopamine-gated ion channel (HcGGR3) from Haemonchus contortus is expressed in the cervical papillae and is associated with macrocyclic lactone resistance. Molecular and Biochemical Parasitology 2009, 166:54-61.
38. Elard L., Sauve C., Humbert J.F. Fitness of benzimidazole-resistant and -susceptible worms of Teladorsagia circumcincta, a nematode parasite of small ruminants. Parasitology 1998, 117(Pt (6)):571-578.