Treatment with IFN-γ prevents insulin-dependent PKB, p70S6k phosphorylation and protein synthesis in mouse C2C12 myogenic cells

Cell Biology International

Volumn 34, Issue 1, 2010, Pages 117-124

  Grzelkowska Kowalczyk, Katarzyna ^a   Wieteska Skrzeczyńska, Wioletta ^a  

^a WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

Glucose transport; Insulin resistance; Interferon ; Protein synthesis; Signalling pathway

Indexed keywords

GAMMA INTERFERON; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYOD PROTEIN; PROTEIN KINASE B; S6 KINASE; MYOGENIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVATION; GLUCOSE TRANSPORT; MOUSE; MUSCLE DEVELOPMENT; MYOTUBE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION; SKELETAL MUSCLE;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; INSULIN; INTERFERON-GAMMA; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MUSCLE FIBERS, SKELETAL; MYOD PROTEIN; MYOGENIN; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION;

EID: 77951918612     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1042/CBI20090135     Document Type: Article

References (32)

1. Acharyya S, Ladner KJ, Nelsen LL, Damrauer J, Reiser PJ, Swoap S, et al. Cancer cachexia is regulated by selective targeting of skeletal muscle gene products. J Clin Invest 2004;114:370-8.
2. Blalock JE. Harnessing a neural-immune circuit to control inflammation and shock. J Exp Med 2002;195:5-8.
3. Borge BA, Kalland K-H, Olsen S, Bletsa A, Berggreen E, Wiig H. Cytokines are produced locally by myocytes in rat skeletal muscle during endotoxemia. Am J Physiol Heart Circ Physiol 2009;296:H735-44.
4. Broussard SR, Zhou JK, Venters HD, Bluthe RM, Freund GG, Johnson RW, et al. At the interface of environment-immune interactions: cytokine and growth factors receptors. J Anim Sci 2001;79:268-84.
5. Broussard SR, McCusker RH, Novakofski JE, Strle K, Shen WH, Johnson RW, et al. Cytokine-hormone interactions: tumor necrosis factor α impairs biologic activity and downstream activation signals of the insulin-like growth factor I receptor in myoblasts. Endocrinology 2003;144:2988-96.
6. Cheng M, Nguyen MH, Fantuzzi G, Koh TJ. Endogenous interferon-( is required for efficient skeletal muscle regeneration. Am J Physiol Cell Physiol 2008;294:C1183-91.
7. Crossland H, Constantin-Teodosiu D, Gardiner SM, Constantin D, Greenhaff PL. A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle. J Physiol 2008;586: 5589-5600.
8. De Alvaro C, Teruel T, Hernandez R, Lorenzo M. Tumor necrosis factor α produces insulin resistance in skeletal muscle by activation of inhibitor κB kinase in a MAPK-dependent manner. J Biol Chem 2004;279:17170-8.
9. De Alvaro C, Nieto-Vazquez I, Rojas JM, Lorenzo M. Nuclear exclusion of forkhead box O and Elk1 and activation of nuclear factor-κBare required for C2C12-RasV12C40 myoblast differentiation. Endocrinology 2008;149:793-801.
10. Dedieu S, Mazères G, Cottin P, Brustis J-J. Involvement of myogenic regulator factors during fusion in the cell line C2C12. Int J Dev Biol 2002;46:235-41.
11. Deldicque L, Theisen D, Bertrand L, Hespel P, Hue L, Francaux M. Creatine enhances differentiation of myogenic C2C12 cells by activating both p38 and Akt/PKB pathways. Am J Physiol Cell Physiol 2007;293:C1263-71.
12. Foulstone EJ, Huser C, Crown AL, Holly JM, Steward CE. Differential signalling mechanisms predisposing primary human skeletal muscle cells to altered proliferation and differentiation: roles of IGF-I and TNF(. Exp Cell Res 2004;294:223-35.
13. Frost RA, Lang CH. Protein kinase B/Akt: a nexus of growth factor and cytokine signaling in determining muscle mass. J Appl Physiol 2007;103:378-87.
14. Frost RA, Lang CH. Regulation of muscle growth by pathogen associated molecules. J Anim Sci 2008;86:E84-93.
15. S6k in mouse C2C12 myogenic cells. Pol J Vet Sci 2006;9:1-10.
16. Gual P, Gremeaux T, Gonzalez T, Le Marchand-Brustel Y, Tanti JF. MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632. Diabetologia 2003;46:1532-42.
17. Gual P, Le Marchand-Brustel Y, Tanti JF. Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 2005;87:99-109.
18. Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, et al. A central role of JNK in obesity and insulin resistance. Nature 2002;420:333-6.
19. Hwa V, Little B, Kofoed EM, Rosenfeld RG. Transcriptional regulation of insulin-like growth factor-I by interferon-γ requires STAT-5b. J Biol Chem 2004;279:2728-36.
20. Khanna S, Roy S, Packer L, Sen CK. Cytokine-induced glucose uptake in skeletal muscle: redox regulation and the role of α-lipoic acid. Am J Physiol 1999;276:R1327-33.
21. Khazen W, Distel E, Collinet M, Chaves VE, M'bika JP, Chany C, et al. Acute and selective inhibition of adipocyte glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase by interferon γ. Endocrinology 2007;148:4007-14.
22. Kim JA, Yeh DC, Ver M, Li Y, Carranza A, Conrads TP, et al. Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pell-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance. J Biol Chem 2005;280:23173-83.
23. Kimball SR, Farrell PA, Jefferson LS. Exercise effects on muscle insulin signaling and action, Invited review: role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise. J Appl Physiol 2002;93:1168-80.
24. Lim MJ, Choi KJ, Ding Y, Kim JH, Kim BS, Kim YH, et al. RhoA/Rho kinase blocks muscle differentiation via serine phosphorylation of insulin receptor substrate-1 and -2. Mol Endocrinol 2007;21:2282-93.
25. Madihally SV, Toner M, Yarmush ML, Mitchell RN. Interferon γ modulates trauma-induced muscle wasting and immune dysfunction. Ann Surg 2002;236:649-57.
26. Mourkioti F, Rosenthal N. IGF-I, inflammation and stem cells: interactions during muscle regeneration. Trends Immunol 2005;26:535-42.
27. Schinner S, Scherbaum WA, Bornstein SR, Barthel A. Molecular mechanisms of insulin resistance. Diabetic Med 2005;22:674-82.
28. Shiba T, Higashi N, Nishimura Y. Hyperglycaemia due to insulin resistance caused by interferon-γ. Diabetic Med 1998;15: 435-6.
29. Smith MA, Moylan JS, Smith JD, Li W, Reid MB. IFN-γ does not mimic the catabolic effects of TNF-α. Am J Physiol Cell Physiol 2007;293:C1947-52.
30. Waite KJ, Floyd ZE, Arbour-Reily P, Stephens JM. Interferon-γ-induced regulation of peroxisome proliferator-activated receptor γ and STATs in adipocytes. J Biol Chem 2001;276:7062-8.
31. Wieteska-Skrzeczyńska W, Grzelkowska-Kowalczyk K. The impairment of IGF-I-stimulated differentiation of mouse C2C12 myogenic cells exposed to TNF-α, IL-1β and IFN-γ. J Physiol Pharmacol 2006;57(suppl.2):242.
32. Wynes MW, Riches DW. Induction of macrophage insulin-like growth factor-I expression by the Th2 cytokines IL-4 and IL-13. J Immunol 2003;171:3550-9.