Cardiac gene expression and systemic cytokine profile are complementary in a murine model of post-ischemic heart failure

Brazilian Journal of Medical and Biological Research

Volumn 43, Issue 4, 2010, Pages 377-389

  Lachtermacher, S ^a   Esporcatte, B L B ^a   Montalvao F ^a   Costa, P C ^a   Rodrigues, D C ^a   Belem, L ^b   Rabischoffisky, A ^b   Faria Neto, H C C ^c   Vasconcellos, R ^d   Iacobas, S ^e   Iacobas, D A ^e   Dohmann, H F R ^b   Spray, D C ^e   Goldenberg, R C S ^a   Campos de Carvalho, A C ^a,e  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b HOSPITAL PRÓ CARDÍACO   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Anti heart antibodies; Cytokines; Experimental post ischemic heart failure; Immunoarray; RNAm Microarray

Indexed keywords

CHEMOKINE; CHEMOKINE KC; COMPLEMENT; CYTOKINE; GAMMA INTERFERON; HEART ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; HEART FAILURE; HEART MUSCLE ISCHEMIA; HYBRIDIZATION; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; RNA SEQUENCE; SEQUENCE ANALYSIS; UPREGULATION;

MURINAE; MUS;

EID: 77951883730     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2010007500014     Document Type: Article

References (34)

1. Volpe M, Tocci G. Integrated cardiovascular risk management for the future: lessons learned from the ASCOT trial. Aging Clin Exp Res 2005; 17: 46-53.
2. Anversa P, Li P, Zhang X, Olivetti G, Capasso JM. Ischaemic myocardial injury and ventricular remodelling. Cardiovasc Res 1993; 27: 145-157.
3. Sutton MG, Sharpe N. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 2000; 101: 2981-2988.
4. Entman ML, Smith CW. Postreperfusion inflammation: a model for reaction to injury in cardiovascular disease. Cardiovasc Res 1994; 28: 1301-1311.
5. Frangogiannis NG, Youker KA, Rossen RD, Gwechenberger M, Lindsey MH, Mendoza LH, et al. Cytokines and the microcirculation in ischemia and reperfusion. J Mol Cell Cardiol 1998; 30: 2567-2576.
6. Mehta JL, Li DY. Inflammation in ischemic heart disease: response to tissue injury or a pathogenetic villain? Cardiovasc Res 1999; 43: 291-299.
7. Williams JG, Jurkovich GJ, Maier RV. Interferon-gamma: a key immunoregulatory lymphokine. J Surg Res 1993; 54: 79-93.
8. Cheng X, Liao YH, Ge H, Li B, Zhang J, Yuan J, et al. TH1/ TH2 functional imbalance after acute myocardial infarction: coronary arterial inflammation or myocardial inflammation. J Clin Immunol 2005; 25: 246-253.
9. Byrne CE, Fitzgerald A, Cannon CP, Fitzgerald DJ, Shields DC. Elevated white cell count in acute coronary syndromes: relationship to variants in inflammatory and thrombotic genes. BMC Med Genet 2004; 5: 13.
10. Torre-Amione G, Kapadia S, Benedict C, Oral H, Young JB, Mann DL. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol 1996; 27: 1201-1206.
11. Frangogiannis NG, Entman ML. Chemokines in myocardial ischemia. Trends Cardiovasc Med 2005; 15: 163-169.
12. Frangogiannis NG, Smith CW, Entman ML. The inflammatory response in myocardial infarction. Cardiovasc Res 2002; 53: 31-47.
13. Mari D, Di Berardino F, Cugno M. Chronic heart failure and the immune system. Clin Rev Allergy Immunol 2002; 23: 325-340.
14. Jahns R, Boivin V, Krapf T, Wallukat G, Boege F, Lohse MJ. Modulation of beta1-adrenoceptor activity by domain-specific antibodies and heart failure-associated autoantibodies. J Am Coll Cardiol 2000; 36: 1280-1287.
15. Gould KE, Taffet GE, Michael LH, Christie RM, Konkol DL, Pocius JS, et al. Heart failure and greater infarct expansion in middle-aged mice: a relevant model for postinfarction failure. Am J Physiol Heart Circ Physiol 2002; 282: H615-H621.
16. Gao XM, Dart AM, Dewar E, Jennings G, Du XJ. Serial echocardiographic assessment of left ventricular dimensions and function after myocardial infarction in mice. Cardiovasc Res 2000; 45: 330-338.
17. Eriksson S, Halenius H, Pulkki K, Hellman J, Pettersson K. Negative interference in cardiac troponin I immunoassays by circulating troponin autoantibodies. Clin Chem 2005; 51: 839-847.
18. Nobrega A, Stransky B, Nicolas N, Coutinho A. Regeneration of natural antibody repertoire after massive ablation of lymphoid system: robust selection mechanisms preserve antigen binding specificities. J Immunol 2002; 169: 2971-2978.
19. Szodoray P, Alex P, Brun JG, Centola M, Jonsson R. Circulating cytokines in primary Sjogren's syndrome determined by a multiplex cytokine array system. Scand J Immunol 2004; 59: 592-599.
20. Iacobas DA, Iacobas S, Urban-Maldonado M, Spray DC. Sensitivity of the brain transcriptome to connexin ablation. Biochim Biophys Acta 2005; 1711: 183-196.
21. Iacobas DA, Iacobas S, Li WE, Zoidl G, Dermietzel R, Spray DC. Genes controlling multiple functional pathways are transcriptionally regulated in connexin43 null mouse heart. Physiol Genomics 2005; 20: 211-223.
22. Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR. GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat Genet 2002; 31: 19-20.
23. Doniger SW, Salomonis N, Dahlquist KD, Vranizan K, Lawlor SC, Conklin BR. MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data. Genome Biol 2003; 4: R7.
24. Lange LG, Schreiner GF. Immune mechanisms of cardiac disease. N Engl J Med 1994; 330: 1129-1135.
25. Smith SC, Allen PM. The role of T cells in myosin-induced autoimmune myocarditis. Clin Immunol Immunopathol 1993; 68: 100-106.
26. Varda-Bloom N, Leor J, Ohad DG, Hasin Y, Amar M, Fixler R, et al. Cytotoxic T lymphocytes are activated following myocardial infarction and can recognize and kill healthy myocytes in vitro. J Mol Cell Cardiol 2000; 32: 2141-2149.
27. Matache C, Stefanescu M, Ivanov D, Szegli G, Popescu P, Filip Z. Presence and significance of some antibodies/ autoantibodies in patients with acute myocardial infarction and idiopathic dilated cardiomyopathy. Roum Arch Microbiol Immunol 1992; 51: 197-203.
28. Melguizo C, Prados J, Velez C, Aranega AE, Marchal JA, Aranega A. Clinical significance of antiheart antibodies after myocardial infarction. Jpn Heart J 1997; 38: 779-786.
29. Hosenpud JD, Campbell SM, Mendelson DJ. Interleukin-1- induced myocardial depression in an isolated beating heart preparation. J Heart Transplant 1989; 8: 460-464.
30. Siwik DA, Chang DL, Colucci WS. Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro. Circ Res 2000; 86: 1259-1265.
31. Lyn D, Liu X, Bennett NA, Emmett NL. Gene expression profile in mouse myocardium after ischemia. Physiol Genomics 2000; 2: 93-100.
32. Nanni L, Romualdi C, Maseri A, Lanfranchi G. Differential gene expression profiling in genetic and multifactorial cardiovascular diseases. J Mol Cell Cardiol 2006; 41: 934-948.
33. Alvarez FL, Neu N, Rose NR, Craig SW, Beisel KW. Heart-specific autoantibodies induced by Coxsackievirus B3: identification of heart autoantigens. Clin Immunol Immunopathol 1987; 43: 129-139.
34. Matsui S, Fu ML, Katsuda S, Hayase M, Yamaguchi N, Teraoka K, et al. Peptides derived from cardiovascular G-protein-coupled receptors induce morphological cardiomyopathic changes in immunized rabbits. J Mol Cell Cardiol 1997; 29: 641-655.