Airway neutrophil inflammatory phenotype in older subjects with asthma

Journal of Allergy and Clinical Immunology

Volumn 125, Issue 5, 2010, Pages 1163-1165

  Nyenhuis, Sharmilee M ^a,c   Schwantes, Elizabeth A ^a   Evans, Michael D ^b   Mathur, Sameer K ^a  

^a Section of Allergy   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CORTICOSTEROID; GELATINASE B; IMMUNOGLOBULIN E; INTERLEUKIN 8; LEUKOCYTE ELASTASE; ORAL CONTRACEPTIVE AGENT;

ADULT; AGED; ASTHMA; BLOOD ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL COUNT; FORCED EXPIRATORY VOLUME; HUMAN; LETTER; LUNG VOLUME; NEUTROPHIL; NEUTROPHIL COUNT; PHENOTYPE; PRICK TEST; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SPUTUM ANALYSIS; TREATMENT OUTCOME; VITAL CAPACITY;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ASTHMA; HUMANS; INFLAMMATION; MIDDLE AGED; NEUTROPHILS; PHENOTYPE; RESPIRATORY SYSTEM; YOUNG ADULT;

EID: 77951878691     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.02.015     Document Type: Letter

References (9)

1. Enright P.L., McClelland R.L., Newman A.B., Gottlieb D.J., and Lebowitz M.D. Underdiagnosis and undertreatment of asthma in the elderly. Chest 116 (1999) 603-613
2. Moorman J.E., Rudd R.A., Johnson C.A., King M., Minor P., Bailey C., et al. National Surveillance for Asthma- United States, 1980-2004. MMWR Surveill Summ 56 (2007) 1-54
3. Jatakanon A., Uasuf C., Maziak W., Lim S., Chung K.F., and Barnes P.J. Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med 160 (1999) 1532-1539
4. Simpson J.L., Scott R.J., Boyle M.J., and Gibson P.G. Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma. Am J Respir Crit Care Med 172 (2005) 559-565
5. Cundall M., Sun Y.C., Miranda C., Trudeau J.B., Barnes S., and Wenzel S.E. Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocortcoids. J Allergy Clin Immunol 112 (2003) 1064-1071
6. Wenzel S.E. Asthma: defining of the persistent adult phenotypes. Lancet 368 (2006) 804-813
7. Meyer K.C., Rosenthal N.S., Soergel P., and Peterson K. Neutrophils and low-grade inflammation in the seemingly normal aging human lung. Mech Ageing Dev 104 (1998) 169-181
8. Mathur S.K., Schwantes E.A., Jarjour N.N., and Busse W.W. Age-related changes in eosinophil function in human subjects. Chest 133 (2008) 412-419
9. Banerji A., Clark S., Afilalo M., Blanda M.P., Cydulka R.K., and Camargo C.A. Prospective multicenter study of acute asthma in younger versus older adults presenting to the emergency department. J Am Geriatr Soc 54 (2006) 48-55