Preliminary evidence of a high risk of bleeding on aspirin plus clopidogrel in aspirin-naïve patients in the acute phase after TIA or minor ischaemic stroke

Cerebrovascular Diseases

Volumn 29, Issue 5, 2010, Pages 460-467

  Geraghty, O C ^a   Kennedy, J ^a   Chandratheva, A ^a   Marquardt, L ^a   Buchan, A M ^a   Rothwell, P M ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Aspirin; Clopidogrel; Hemorrhage; Stroke

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; DIPYRIDAMOLE; WARFARIN;

AGED; ARTICLE; BLEEDING; BLOOD TRANSFUSION; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EXPOSURE; EVIDENCE BASED MEDICINE; FEMALE; FOLLOW UP; GASTROINTESTINAL HEMORRHAGE; HIGH RISK PATIENT; HUMAN; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PATIENT MONITORING; PRIORITY JOURNAL; RISK ASSESSMENT; TRANSIENT ISCHEMIC ATTACK;

AGED; ASPIRIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HEMORRHAGE; HUMANS; INCIDENCE; ISCHEMIC ATTACK, TRANSIENT; LONGITUDINAL STUDIES; MALE; PLATELET AGGREGATION INHIBITORS; RETROSPECTIVE STUDIES; RISK FACTORS; STROKE; TICLOPIDINE;

EID: 77951851824     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000297961     Document Type: Article

References (24)

1. Rothwell PM, Giles MF, Flossmann E, Lovelock CE, Redgrave JN, Warlow CP: A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. Lancet 2005; 366: 29-36. (Pubitemid 40956527)
2. Johnstone SC, Rothwell PM: Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet 2007; 369: 283-292. (Pubitemid 46136488)
3. Diener HC, Bogousslavsky J, Brass LM, Cimminiello C, Csiba L, Kaste M, Leys D, Matius- Guiu J, Rupprecht HJ: Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high risk patients (MATCH): randomised, double- blind, placebo- controlled trial. Lancet 2004; 364: 331-337. (Pubitemid 39458141)
4. Lovett JK, Coull AJ, Rothwell PM: Early risk of recurrence by subtype of ischaemic stroke in population-based incidence studies. Neurology 2004: 62: 569-573.
5. Markus HS, Droste DW, Kaps M, Larrue V, Lees K, Siebler M, Ringelstein EB: Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using Doppler embolic detection signal. (CARESS) trial. Circulation 2005; 111: 2233-2240.
6. Payne DA, Jones CL, Hayes PD, Thompson MM, London NJ, Bell PR, Alison H, Naylor AR: Beneficial effects of clopidogrel combined with aspirin in reducing cerebral emboli in patients undergoing carotid endarterectomy. Circulation 2004; 109: 1476-1481.
7. Kennedy J, Hill MD, Ryckborst KJ, Eliasziw M, Demchuk AM, Buchan AM: Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial. Lancet Neurol 2007; 6: 961-969. (Pubitemid 47562312)
8. Bhatt DL, Fox KA, Hacke W, Berger PB, Black HR, Boden WE: Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. New Engl J Med 2006; 354: 1706-1717.
9. Rothwell PM, Giles MF, Chandratheva A, Marquardt L, Geraghty O, Redgrave JN: Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet 2007; 370: 1432-1442. (Pubitemid 47576154)
10. Rothwell PM, Coull AJ, Silver LE, Fairhead JF, Giles MF, Lovelock CE: Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study). Lancet 2005; 366: 1773-1783.
11. Rothwell PM, Coull AJ, Giles MF, Howard SC, Silver LE, Bull LM: Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study). Lancet 2004; 363: 1925-1933.
12. Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK: Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001; 345: 494-502. (Pubitemid 32758501)
13. Van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJA, van Gijn J: Interoberserver agreement for the assessment of handicap in stroke patients. Stroke 1988; 19: 604-607.
14. Connolly S, Pogue J, Hart R, Pfeffer M, Hohnloser S, Chrolavicius S: Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial. Lancet 2006; 367: 1903-1912.
15. Bowry A, Brookhart A, Niteesh K, Choudhry N: Meta-analysis of the efficacy and safety of clopidogrel plus aspirin as compared to antiplatelet monotherapy for the prevention of vascular events. Am J Cardiol 2008; 101: 960-966.
16. Lai KC, Lam SK, Chu KM, Wong BC, Hui WM, Hu WH, et al: Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl J Med 2002; 346: 2033-2038. (Pubitemid 34680594)
17. Liberopoulos EN, Elisaf MS, Tselepis AD, Archimandritis A, Kiskinis D, Cokkinos D, et al: Upper gastrointestinal haemorrhage complicating antiplatelet treatment with aspirin and/or clopidogrel: where we are now? Platelets 2006; 17: 1-6. (Pubitemid 41759234)
18. Bhatt DL, Scheiman J, Abraham NS, Antman EM, Chan FK, Furberg CD, et al: ACCF/ ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation 2008; 118: 1894-1909.
19. Jones R, Lydeard S: Prevalence of symptoms of dyspepsia in the community. BMJ 1989; 298: 30-32. (Pubitemid 19022888)
20. Lai KC, Lam SK, Chu KM, Wong BC, Hui WM, Hu WH: Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl J Med 2002; 346: 2033-2038. (Pubitemid 34680594)
21. Sacco RL, Diener HC, Yusuf S, Cotton D, Ounpuu S, Lawton WA: Aspirin and extended- release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med 2008; 359: 1238-1251.
22. Sprigg N, Gray LJ, England T, Willmot MR, Zhao L, Sare GM: A randomised controlled trial of triple antiplatelet therapy (aspirin, clopidogrel and dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility. PLoS ONE 2008; 3:e2852.
23. Aubert RE, Epstein RS, Teagarden JR, Xia F, Yao J, Desta Z, Skaar T, Flockhart DA: Proton pump inhibitors effect on clopidogrel effectiveness: The Clopidogrel Medco Outcomes Study. Circulation 2008; 118:S815.
24. Gilard M, Arnaud B, Cornily JC, Le Gal G, Lacut K, Le Calvez G: Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. J Am Coll Cardiol 2008; 51: 256-260.