Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for prostate cancer genetics using novel sumLINK and sumLOD analyses

Prostate

Volumn 70, Issue 7, 2010, Pages 735-744

  Christensen, G Bryce ^a   Baffoe Bonnie, Agnes B ^b,c,d   George, Asha ^b,c   Powell, Isaac ^b,e   Bailey Wilson, Joan E ^b,d   Carpten, John D ^b,f   Giles, Graham G ^g,h   Hopper, John L ^g,i   Severi, Gianluca ^g,h   English, Dallas R ^g,i   Foulkes, William D ^g,j   Maehle, Lovise ^g,k   Moller, Pal ^g,k   Eeles, Ros ^g,l   Easton, Douglas ^g,m   Badzioch, Michael D ^g,n   Whittemore, Alice S ^o,p,q   Oakley Girvan, Ingrid ^o,q   Hsieh, Chih Lin ^o,r   Dimitrov, Latchezar ^s   Xu, Jianfeng ^s   Stanford, Janet L ^t   Johanneson, Bo ^t,u   Deutsch, Kerry ^t,v   McIntosh, Laura ^t   Ostrander, Elaine A ^t,u   Wiley, Kathleen E ^w   Isaacs, Sarah D ^w   Walsh, Patrick C ^w   Isaacs, William B ^w   Thibodeau, Stephen N ^x   McDonnell, Shannon K ^x   Hebbring, Scott ^x   Schaid, Daniel J ^x   Lange, Ethan M ^y,z   Cooney, Kathleen A ^y   Tammela, Teuvo L J ^aa   Schleutker, Johanna ^aa   Paiss, Thomas ^ab   Maier, Christiane ^ab   Grönberg, Henrik ^ac,ad   Wiklund, Fredrik ^ac,ad   Emanuelsson, Monica ^ac   Farnham, James M ^a   Cannon Albright, Lisa A ^a   Camp, Nicola J ^a   more..

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b African American Hereditary Prostate Cancer ICPCG Group   (United States)

^c FOX CHASE CANCER CENTER   (United States)

^d NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^e WAYNE STATE UNIVERSITY   (United States)

^f TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^g ACTANE Consortium ICPCG Group   (United States)

^h CANCER EPIDEMIOLOGY CENTRE   (Australia)

ⁱ UNIVERSITY OF MELBOURNE   (Australia)

^j MCGILL UNIVERSITY   (Canada)

^k OSLO UNIVERSITY HOSPITAL   (Norway)

^l INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^m IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

ⁿ UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^o BC/CA/HI ICPCG Group   (United States)

^p STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^q STANFORD CANCER INSTITUTE   (United States)

^r UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^s WAKE FOREST SCHOOL OF MEDICINE   (United States)

^t Fred Hutchinson Cancer Research Center   (United States)

^u NATIONAL INSTITUTES OF HEALTH   (United States)

^v INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^w DEPARTMENT OF PATHOLOGY   (United States)

^x MAYO CLINIC   (United States)

^y UNIVERSITY OF MICHIGAN   (United States)

^z UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^aa TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^ab UNIVERSITY OF ULM   (Germany)

^ac UMEÅ UNIVERSITY   (Sweden)

^ad KAROLINSKA INSTITUTE   (Sweden)

more..

Author keywords

Cancer; Genetic epidemiology; Meta analysis; Predisposition; Susceptibility

Indexed keywords

ARTICLE; CANCER GENETICS; CHROMOSOME 22Q; CONTROLLED STUDY; GENE LOCUS; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENOME ANALYSIS; LINKAGE ANALYSIS; PEDIGREE ANALYSIS; PRIORITY JOURNAL; PROSTATE CANCER;

CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 22; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; PEDIGREE; PROSTATIC NEOPLASMS;

EID: 77951839049     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.21106     Document Type: Article

References (27)

1. Schaid D. The complex genetic epidemiology of prostate cancer. Hum Mol Gen 2004;13(Suppl. 1):R103-R121. (Pubitemid 38443804)
2. Ostrander EA, Stanford JL. Genetics of prostate cancer: Too many loci, too few genes. Am J Hum Genet 2000;67(6):1367-1375.
3. Witte JS. Prostate cancer genomics: Towards a new understanding. Nat Rev 2009;10(2):77-82.
4. Ghoussaini M, Song H, Koessler T, Al Olama AA, Kote-Jarai Z, Driver KE, Pooley KA, Ramus SJ, Kjaer SK, Hogdall E, DiCioccio RA, Whittemore AS, Gayther SA, Giles GG, Guy M, Edwards SM, Morrison J, Donovan JL, Hamdy FC, Dearnaley DP, Ardern-Jones AT, Hall AL, O'Brien LT, Gehr-Swain BN, Wilkinson RA, Brown PM, Hopper JL, Neal DE, Pharoah PD, Ponder BA, Eeles RA, Easton DF, Dunning AM. Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst 2008;100(13):962-966. (Pubitemid 351957516)
5. Luo JH, Yu YP. Genetic factors underlying prostate cancer. Exp Rev Mol Med 2003;5(12):1-26.
6. Yoshimoto M, Joshua AM, Chilton-Macneill S, Bayani J, Selvarajah S, Evans AJ, Zielenska M, Squire JA. Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement. Neoplasia 2006;8(6):465-469. (Pubitemid 44035330)
7. Liu W, Chang B, Sauvageot J, Dimitrov L, Gielzak M, Li T, Yan G, Sun J, Sun J, Adams TS, Turner AR, Kim JW, Meyers DA, Zheng SL, Isaacs WB, Xu J. Comprehensive assessment of DNA copy number alterations in human prostate cancers using Affymetrix 100K SNP mapping array. Genes, Chromosomes Cancer 2006; 45(11):1018-1032. (Pubitemid 44435536)
8. Xu J, Dimitrov L, Chang BL, Adams TS, Turner AR, Meyers DA, Eeles RA, Easton DF, Foulkes WD, Simard J, Giles GG, Hopper JL, Mahle L, Moller P, Bishop T, Evans C, Edwards S, Meitz J, Bullock S, Hope Q, Hsieh CL, Halpern J, Balise RN, Oakley-Girvan I, Whittemore AS, Ewing CM, Gielzak M, Isaacs SD, Walsh PC, Wiley KE, Isaacs WB, Thibodeau SN, McDonnell SK, Cunningham JM, Zarfas KE, Hebbring S, Schaid DJ, Friedrichsen DM, Deutsch K, Kolb S, Badzioch M, Jarvik GP, Janer M, Hood L, Ostrander EA, Stanford JL, Lange EM, Beebe-Dimmer JL, Mohai CE, Cooney KA, Ikonen T, Baffoe-Bonnie A, Fredriksson H, Matikainen MP, Tammela T, Bailey-Wilson J, Schleutker J, Maier C, Herkommer K, Hoegel JJ, Vogel W, Paiss T, Wiklund F, Emanuelsson M, Stenman E, Jonsson BA, Gronberg H, Camp NJ, Farnham J, Cannon-Albright LA, Seminara D. A combined genomewide linkage scan of 1,233 families for prostate cancersusceptibility genes conducted by the International Consortium for Prostate Cancer Genetics. Am J Hum Genet 2005;77(2):219-229. (Pubitemid 41022705)
9. Camp NJ, Cannon-Albright LA, Farnham JM, Baffoe-Bonnie AB, George A, Powell I, Bailey-Wilson JE, Carpten JD, Giles GG, Hopper JL, Severi G, English DR, Foulkes WD,Maehle L, Moller P, Eeles R, Easton D, Badzioch MD, Whittemore AS, Oakley- Girvan I, Hsieh CL, Dimitrov L, Xu J, Stanford JL, Johanneson B, Deutsch K, McIntosh L, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Thibodeau SN, McDonnell SK, Hebbring S, Schaid DJ, Lange EM, Cooney KA, Tammela TL, Schleutker J, Paiss T, Maier C, Gronberg H, Wiklund F, Emanuelsson M, Isaacs WB. Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics. Hum Mol Genet 2007;16(11):1271-1278. (Pubitemid 47055123)
10. Schaid DJ, Chang BL. Description of the International Consortium for Prostate Cancer Genetics, and failure to replicate linkage of hereditary prostate cancer to 20q13. Prostate 2005;63(3):276-290. (Pubitemid 40571062)
11. Christensen GB, Knight S, Camp NJ. The sumLINK statistic for genetic linkage analysis in the presence of heterogeneity. Genet Epidemiol 2009;33(7):628-639.
12. Lander E, Kruglyak L. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 1995;11(3):241-247.
13. Chen L, Storey JD. Relaxed significance criteria for linkage analysis. Genetics 2006;173:2371-2381. (Pubitemid 44285709)
14. Camp NJ, Farnham JM, Cannon-Albright L. Localization of a prostate cancer predisposition gene to an 880-kb region of chromosome 22q12.3 in Utah high-risk pedigrees. Cancer Res 2006;66(20):10205-10212. (Pubitemid 44672076)
15. Schaid D, ICPCG. Pooled genome linkage scan of aggressive prostate cancer: Results from the International Consortium for Prostate Cancer Genetics. Hum Genet 2006;120(4):471-485.
16. Berry R, Schroeder JJ, French AJ, McDonnell SK, Peterson BJ, Cunningham JM, Thibodeau SN, Schaid DJ. Evidence for a prostate cancer-susceptibility locus on chromosome 20. Am J Hum Genet 2000;67(1):82-91. (Pubitemid 30481546)
17. Cunningham JM, McDonnell SK, Marks A, Hebbring S, Anderson SA, Peterson BJ, Slager S, French A, Blute ML, Schaid DJ, Thibodeau SN. Genome linkage screen for prostate cancer susceptibility loci: Results from the Mayo Clinic Familial Prostate Cancer Study. Prostate 2003;57(4):335-346. (Pubitemid 37487079)
18. Smith JR, Freije D, Carpten JD, Gronberg H, Xu J, Isaacs SD, Brownstein MJ, Bova GS, Guo H, Bujnovszky P, Nusskern DR, Damber JE, Bergh A, Emanuelsson M, Kallioniemi OP, Walker-Daniels J, Bailey-Wilson JE, Beaty TH, Meyers DA, Walsh PC, Collins FS, Trent JM, Isaacs WB. Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science 1996;274(5291):1371-1374. (Pubitemid 26391460)
19. Carpten J, Nupponen N, Isaacs S, Sood R, Robbins C, Xu J, Faruque M, Moses T, Ewing C, Gillanders E, HuP, Bujnovszky P, Makalowska I, Baffoe-Bonnie A, Faith D, Smith J, Stephan D, Wiley K, Brownstein M, Gildea D, Kelly B, Jenkins R, Hostetter G, Matikainen M, Schleutker J, Klinger K, Connors T, Xiang Y, Wang Z, De Marzo A, Papadopoulos N, Kallioniemi OP, Burk R, Meyers D, Gronberg H, Meltzer P, Silverman R, Bailey-Wilson J, Walsh P, Isaacs W, Trent J. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat Genet 2002;30(2):181-184.
20. Xu J, Zheng SL, Hawkins GA, Faith DA, Kelly B, Isaacs SD, Wiley KE, Chang B, Ewing CM, Bujnovszky P, Carpten JD, Bleecker ER, Walsh PC, Trent JM, Meyers DA, Isaacs WB. Linkage and association studies of prostate cancer susceptibility: Evidence for linkage at 8p.22-23. Am J Hum Genet 2001;69(2):341-350. (Pubitemid 32695206)
21. Chang BL, Liu W, Sun J, Dimitrov L, Li T, Turner AR, Zheng SL, Isaacs WB, Xu J. Integration of somatic deletion analysis of prostate cancers and germline linkage analysis of prostate cancer families reveals two small consensus regions for prostate cancer genes at 8p. Cancer Res 2007;67(9):4098-4103. (Pubitemid 46815054)
22. Neville PJ, Conti DV, Krumroy LM, Catalona WJ, Suarez BK, Witte JS, Casey G. Prostate cancer aggressiveness locus on chromosome segment 19q12-q13.1 identified by linkage and allelic imbalance studies. Genes, Chromosomes Cancer 2003; 36(4):332-339. (Pubitemid 36314516)
23. Slager SL, Schaid DJ, Cunningham JM, McDonnell SK, Marks AF, Peterson BJ, Hebbring SJ, Anderson S, French AJ, Thibodeau SN. Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q. Am J Hum Genet 2003;72(3):759-762. (Pubitemid 36255976)
24. Liu W, Sun J, Li G, Zhu Y, Zhang S, Kim ST, Sun J, Wiklund F, Wiley K, Isaacs SD, Stattin P, Xu J, Duggan D, Carpten JD, Isaacs WB, Gronberg H, Zheng SL, Chang BL. Association of a germline copy number variation at 2p24.3 and risk for aggressive prostate cancer. Cancer Res 2009;69(6):2176-2179.
25. Paris PL, Andaya A, Fridlyand J, Jain AN, Weinberg V, Kowbel D, Brebner JH, Simko J, Watson JE, Volik S, Albertson DG, Pinkel D, Alers JC, van der Kwast TH, Vissers KJ, Schroder FH, Wildhagen MF, Febbo PG, Chinnaiyan AM, Pienta KJ, Carroll PR, Rubin MA, Collins C, van Dekken H. Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors. Hum Mol Genet 2004;13(13): 1303-1313. (Pubitemid 38961638)
26. Pal P, Xi H, Sun G, Kaushal R, Meeks JJ, Thaxton CS, Guha S, Jin CH, Suarez BK, Catalona WJ, Deka R. Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin. Hum Genet 2007; 122(3-4):251-259. (Pubitemid 47616533)
27. Slager S, Zarfas KE, Brown WM, Lange E, McDonnell S, Wojno KJ, Cooney KA. Genome-wide linkage scan for prostate cancer aggressiveness loci using families from the University of Michigan Prostate Cancer Genetics Project. Prostate 2006;66(2): 173-179. (Pubitemid 43191238)