The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with idiopathic ischemic stroke in the young mexican-mestizo population

Cerebrovascular Diseases

Volumn 29, Issue 5, 2010, Pages 454-459

  Isordia Salas, Irma ^b   Barinagarrementería Aldatz, Fernando ^a   Leaños Miranda, Alfredo ^c   Borrayo Sánchez, Gabriela ^d   Vela Ojeda, Jorge ^b   García Chávez, Jaime ^b   Ibarra González, Isabel ^e   Majluf Cruz, Abraham ^b  

^a HOSPITAL ÁNGELES DEL PEDREGAL   (Mexico)

^b INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^c Unidad de Investigación Médica en Medicina Reproductiva   (Mexico)

^d Unidad de Cuidados Intensivos Coronarios   (Mexico)

^e INSTITUTO NACIONAL DE PEDIATRÍA   (Mexico)

Author keywords

Genetics; Homocysteine; Idiopathic ischemic stroke; Methylenetetrahydrofolate reductase; Risk factors; Stroke; Young adults

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); GENOMIC DNA; HOMOCYSTEINE; METHIONINE;

ADULT; ALLELE; ARTERY THROMBOSIS; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DNA ISOLATION; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOSITY; HISPANIC; HOMOZYGOSITY; HUMAN; HYPERTENSION; IDIOPATHIC DISEASE; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SMOKING; THROMBOPHILIA;

ADULT; AGE FACTORS; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MEXICO; POLYMORPHISM, GENETIC; RETROSPECTIVE STUDIES; RISK FACTORS; STROKE;

EID: 77951831327     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000289349     Document Type: Article

References (21)

1. Instituto Nacional de Estadística, Geografía e Informática. Censo Nacional de Población y Vivienda 2006 (Mexico). http://www.inegi. org.mx.
2. Hassan A, Markus HS: Genetics and ischemic stroke. Brain 2000; 123: 1784-1812.
3. Xu X, Li J, Sheng W, Liu L: Meta-analysis of genetic studies from journals published in China of ischemic stroke in the Han Chinese population. Cerebrovasc Dis 2008; 26: 48-62. (Pubitemid 351931421)
4. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M: Vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nut Genet 1995; 10: 111-113.
5. Cronin S, Furie KL, Kelly PJ: Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis. Stroke 2005; 36: 1581-1587. (Pubitemid 40967536)
6. Alam MA, Husain SA, Narang R, Chauhan SS, Kabra M, Vasisht S: Association of polymorphism in the thermolabile 5,10-methylenetetrahydrofolate reductase gene and hyperhomocysteinemia with coronary artery disease. Mol Cell Biochem 2008; 310: 111-117.
7. Rallidis LS, Gialeraki A, Komporozos C, Vavoulis P, Pavlakis G, Travlou A, Lekakis I, Kremastinos DT: Role of methylenetetrahydrofolate reductase 677C-T polymorphism in the development of premature myocardial infarction. Atherosclerosis 2008; 200: 115-120.
8. Shi C, Kang X, Wang Y, Zhou Y: The coagulation factor V Leiden, MTHFRC677T variant and eNOS 4ab polymorphism in young Chinese population with ischemic stroke. Clin Chim Acta 2008; 396: 7-9.
9. Marie SK, Shinjo SK, Oba-Shinjo SM, da Silva R, Barbosa KC, Yamamoto F, Scaff M: Methyleneterahydrofolate reductase gene polymorphism is not related to the risk of ischemic cerebrovascular disease in the Brazilian population. Clinics 2007; 62: 295-300.
10. Carducci C, Birarelli M, Nola M, Antonozzi I: Automated high-performance liquid chromatographic method for the determination of homocysteine in plasma samples. J Chromatogr A 1999; 846: 93-100. (Pubitemid 29332628)
11. Madonna P, de Stefano V, Coppola A, Cirrillo F, Cerbone AM, Orefice G, Di Minno G: Hyperhomocysteinemia and other inherited prothrombotic conditions in young adults with a history of ischemic stroke. Stroke 2002; 33: 51-56. (Pubitemid 34052184)
12. Flossman E, Schulz UGR, Rothwell PM: Systematic review of methods and results of studies of the genetic epidemiology of ischemic stroke. Stroke 2004; 35: 212-227.
13. Isordia-Salas I, Leaños-Miranda A, Sainz IM, Reyes-Maldonado E, Borrayo-Sánchez G: Association of the plasminogen activator inhibitor-1 gene 4G/5G polymorphism with ST elevation acute myocardial infarction in young patients. Rev Esp Cardiol 2009; 62: 365-372.
14. De Jong SC, Stehouwer CDA, van den Berg M, Kostense PJ, Alders D, Jakobs C, Pals C, Rauwerda JA: Determinations of fasting and post-methionine homocysteine levels in families predisposed to hyperhomocysteinemia and premature vascular disease. Arterioscler Thromb Vasc Biol 1999; 1316-1324. (Pubitemid 29227653)
15. Alam MA, Husain SA, Narang R, Chauhan SS, Kabra M, Vasisht S: Mild hyperhomocysteinemia is associated with increased TAFI levels and reduced plasma fibrinolytic potential. J Thromb Haemost 2008; 6: 1571-1577.
16. Spence JD: Homocysteine-lowering therapy: a role in stroke prevention. Lancet Neurol 2007; 7: 830-838. (Pubitemid 47241275)
17. Putaala J, Metso AJ, Metso TM, Konkola N, Kraemer Y, Haapaniemi E, Kaste M, Tatlisumak T: Analysis of 1,008 consecutive patients aged from 15 to 49 with first event ischemic stroke: the Helsinki young stroke registry. Stroke 2009; 40: 1195-1203.
18. Casas JP, Hingorani AD, Bautista LE, Sharma P: Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 1,800 cases and 58,000 controls. Arch Neurol 2004; 61: 1652-1661. (Pubitemid 39463422)
19. Pezzini A, Grassi M, Del Zotto E, Archetti S, Spezi R, Vergani V, Assanelli D, Caimi L, Padovani A: Cumulative effect of predisposing genotypes and their interaction with modifiable factors on the risk of ischemic stroke in young adults. Stroke 2005; 36: 533-539. (Pubitemid 40344152)
20. Rook Jl, Nugent DJ, Young G: Pediatric stroke and methylenetetrahydrofolate reductase polymorphisms: an examination of C6777T and A1298C mutations. J Pediatr Hematol Oncol 2005; 27: 590-593. (Pubitemid 41697344)
21. Jerrard-Dunne P, Evans A, McGovern R, Hajat C, Karla L, Rudd AG, Wolfe CD, Markus HS: Ethnic differences in markers of thrombophilia: implications for the investigation of ischemic stroke in multiethnic populations: the South London Ethnicity and Stroke Study. Stroke 2003; 34: 1821-1826. (Pubitemid 36944760)