Inhibitory effect of ginkgo biloba extract on the tonus of the small intestine and the colon of rabbits

Molecules

Volumn 15, Issue 4, 2010, Pages 2079-2086

  Pilija, Vladimir ^a   Mirjana, Radenkovic ^b   Brenesel, Maja Djurendic ^a   Popovic, Mira ^c   Ivetic, Vesna ^d   Trivic, Svetlana ^c  

^a Institute of Forensic Medicine   (Serbia)

^b UNIVERSITY OF NI   (Serbia)

^c UNIVERSITY OF NOVI SAD   (Serbia)

^d UNIVERSITY OF NOVI SAD   (Serbia)

Author keywords

Acetylcholine; Ach; Colon; GBE; Ginkgo biloba; Ileum

Indexed keywords

ACETYLCHOLINE; GINGIUM; PLANT EXTRACT;

ANIMAL; ARTICLE; CHEMISTRY; COLON; DRUG EFFECT; FEMALE; GASTROINTESTINAL MOTILITY; GINKGO BILOBA; ILEUM; MALE; RABBIT; SMALL INTESTINE; SMOOTH MUSCLE;

ACETYLCHOLINE; ANIMALS; COLON; FEMALE; GASTROINTESTINAL MOTILITY; GINKGO BILOBA; ILEUM; INTESTINE, SMALL; MALE; MUSCLE, SMOOTH; PLANT EXTRACTS; RABBITS;

EID: 77951807700     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules15042079     Document Type: Article

References (18)

1. Hansel, R.; Keller, K.; Rimpler, H.; Schneider, G. Hagers Handbuch der Pharmazeutischen Praxis, Drogen E-O 5; Springer-Verlag: Berlin, Germany, 1993; pp. 268-292.
2. DeFeudis, F.V. Ginkgo Biloba Extract (EGb 761): Pharmacological Activities and Clinical Applications; Elsevier: Paris, France, 1991; pp. 1-8.
3. Jaracz, S.; Malik, S,; Nakanishi, K. Isolation of ginkgolides A,B,C,J and bilobalide from G. Biloba extracts. Phytochemistry 2004, 65, 2897-2902. (Pubitemid 40292122)
4. Sasaki, K.; Hatta, S.; Wada, K.; Itoh, M.; Yoshimura, T.; Haga, M. Effects of chronic administration of bilobalide on amino acid levels in mouse brain. Cell. Mol. Biol. 2002, 48, 681-684.
5. Shulz, V.; Hansel, R.; Tyler, V.E. Rational Phytotherapy; Springer-Verlag: Heidelberg-Berlin, Germany, 2001; pp. 42-54.
6. Radenković, M. Zna?aj podtipova muskarinskih receptora (M1, M2, M3) u regulaciji pendularnih pokreta duodenuma, ileuma i kolona. Doctoral dissertation. Univerzitet Niš: Niš, Serbia, 1995.
7. Costa, M.; Furness, J.B. Nervous control of intestinal motility. In Bertaccini G. Mediators and Drugs in Gastrointestinal Motility: Handbook of Experimental Pharmacology; Springer-Verlag: Berlin, Germany, 1982; pp. 279-382.
8. Beleslin, D.; Samardžić, R. The effect of muscarine on cholinoceptive neurones subserving the peristaltic reflex of guinea-pig isolated ileum. Neuropharmacology 1978, 17, 793-798. (Pubitemid 9100407)
9. Grider, J.R. Identification of neurotransmitters regulating intestinal peristaltic reflex in humans. Gastroenterology 1989, 97, 1414-1419.
10. Ruoff. J.; Fladung, B.; Demol, P.; Weihrauch, T.R. Gastrointestinal receptors and drugs in motility disorders. Digestion 1991, 48, 1-17.
11. Goyal, R.K. Muscarinic receptor subtypes. N. Eng. J. Med. 1989, 321, 1022-1029.
12. Kilbinger, H.; Halim, S.; Lambrecht, G.; Weiler, W.; Wessler, I. Comparison of affinities of muscarinic antagonists to pre- and postjunctional receptors in the guinea-pig ileum. Eur. J. Pharmacol. 1984, 103, 313-320. (Pubitemid 14028988)
13. Radenković, M.; Samardžić, R.; Veljković, S.; Beleslin, D. Excitatory muscarinic M1 receptors in the control of the pendular movements of the rabbit distal colon. Yugoslav. Physiol. Pharmacol. Acta 1998, 34, 569-576.
14. Sugiyama, T.; Kubota, Y.; Shinozuka, K.; Yamada, S.; Yamada, K.; Umegaki, K. Induction and recovery of hepatic drug metabolizing enzymes in rats treated with Ginkgo biloba extract. Food Chem. Toxicol. 2004, 42, 953-957. (Pubitemid 38515779)
15. Kubota, Y.; Tanaka, T.; Umegaki, K. Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level. Life Sci. 2001, 69, 2327-2336. (Pubitemid 32971963)
16. Foutillan, J.B.; Brisson, A.M.; Girault, J.; Ingrand, I.; Decourt, J.P.; Drieu, K. Phamacokinetic properties of bilobalide and ginkgolides A and B in healthy subjects after intravenous and oral administration of Ginkgo biloba extract (EGb 761). Therapie 1995, 50, 137-144.
17. Gertz, H.J.; Kiefer, M. Review about Ginkgo Biloba Special Extract Egb 761 (Ginkgo). Curr. Pharm. Des. 2004, 4, 261-264. (Pubitemid 38072762)
18. Nishida, S.; Satoh, H. Age-related changes in the vasodilating actions of Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta. Clin. Chim. Acta 2005, 354, 141-146. (Pubitemid 40320684)