Comparison of parathyroid hormone and G-CSF treatment after myocardial infarction on perfusion and stem cell homing

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 298, Issue 5, 2010, Pages

  Huber, Bruno C ^a   Fischer, Rebekka ^a   Brunner, Stefan ^a   Groebner, Michael ^a   Rischpler, Christoph ^a   Segeth, Alexander ^a   Zaruba, Marc M ^a   Wollenweber, Tim ^a   Hacker, Marcus ^a   Franz, Wolfgang Michael ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Cytokines; Myocardial infarction; Parathyroid hormone; Regenerative medicine; Remodeling

Indexed keywords

ATAXIN 1; GRANULOCYTE COLONY STIMULATING FACTOR; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; PARATHYROID HORMONE; STEM CELL FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; BLOOD; C57BL 6 MOUSE; CELL CLONING; CELL COUNT; CELL HOMING; CELL MIGRATION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; FLUORESCENCE ACTIVATED CELL SORTING; HEART INFARCTION; HEART PERFUSION; HEMATOPOIETIC STEM CELL; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STEM CELL MOBILIZATION;

ANIMALS; BONE MARROW TRANSPLANTATION; CORONARY CIRCULATION; CYTOKINES; FLOW CYTOMETRY; GRANULOCYTE COLONY-STIMULATING FACTOR; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCARDIUM; PARATHYROID HORMONE; PERFUSION; RADIOPHARMACEUTICALS; TECHNETIUM TC 99M SESTAMIBI; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TREATMENT OUTCOME;

EID: 77951803729     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00033.2010     Document Type: Article

References (28)

1. Assmus B, Honold J, Schachinger V, Britten MB, Fischer-Rasokat U, Lehmann R, Teupe C, Pistorius K, Martin H, Abolmaali ND, Tonn T, Dimmeler S, Zeiher AM. Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 355: 1222-1232, 2006. (Pubitemid 44427446)
2. Ballen KK, Shpall EJ, Avigan D, Yeap BY, Fisher DC, McDermott K, Dey BR, Attar E, McAfee S, Konopleva M, Antin JH, Spitzer TR. Phase I trial of parathyroid hormone to facilitate stem cell mobilization. Biol Blood Marrow Transplant 13: 838-843, 2007. (Pubitemid 46902439)
3. Brunner S, Engelmann MG, Franz WM. Stem cell mobilisation for myocardial repair. Expert Opin Biol Ther 8: 1675-1690, 2008.
4. Brunner S, Huber BC, Fischer R, Groebner M, Hacker M, David R, Zaruba MM, Vallaster M, Rischpler C, Wilke A, Gerbitz A, Franz WM. G-CSF treatment after myocardial infarction: impact on bone marrow-derived vs cardiac progenitor cells. Exp Hematol 36: 695-702. Epub 2008 Mar 2017, 2008.
5. Brunner S, Theiss HD, Murr A, Negele T, Franz WM. Primary hyperparathyroidism is associated with increased circulating bone marrow-derived progenitor cells. AM J Physiol Endocrinol Metab 293: E1670-E1675, 2007. (Pubitemid 350255118)
6. Brunner S, Zaruba MM, Huber B, David R, Vallaster M, Assmann G, Mueller-Hoecker J, Franz WM. Parathyroid hormone effectively induces mobilization of progenitor cells without depletion of bone marrow. Exp Hematol 36: 1157-1166, 2008.
7. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, Martin RP, Schipani E, Divieti P, Bringhurst FR, Milner LA, Kronenberg LM, Scadden DT. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425: 841-846, 2003. (Pubitemid 37351468)
8. Deindl E, Zaruba MM, Brunner S, Huber B, Mehl U, Assmann G, Hoefer IE, Mueller-Hoecker J, Franz WM. G-CSF administration after myocardial infarction in mice attenuates late ischemic cardiomyopathy by enhanced arteriogenesis. Faseb J 20: 956-958, 2006.
9. Dimmeler S, Zeiher AM, Schneider MD. Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest 115: 572-583, 2005. (Pubitemid 40322227)
10. Engelmann MG, Franz WM. Stem cell therapy after myocardial infarction: ready for clinical application? Curr Opin Mol Ther 8: 396-414, 2006. (Pubitemid 44566781)
11. Engelmann MG, Theiss HD, Hennig-Theiss C, Huber A, Wintersperger BJ, Werle-Ruedinger AE, Schoenberg SO, Steinbeck G, Franz WM. Autologous bone marrow stem cell mobilization induced by granulocyte colony-stimulating factor after subacute ST-segment elevation myocardial infarction undergoing late revascularization: final results from the G-CSF-STEMI (Granulocyte Colony-Stimulating Factor ST-Segment Elevation Myocardial Infarction) trial. J Am Coll Cardiol 48: 1712-1721, 2006. (Pubitemid 44528196)
12. Feola M, Gonzales H, Canizaro PC. Vasoactive parathyroid hormone in the treatment of acute ischemic left ventricular failure and the prevention of cardiogenic shock. Circ Shock 17: 163-177, 1985. (Pubitemid 16221444)
13. Jansen J, Gres P, Umschlag C, Heinzel FR, Degenhardt H, Schlüter KD, Heusch G, Schulz R. Parathyroid hormone-related peptide improves contractile function of stunned myocardium in rats and pigs. Am J Physiol Heart Circ Physiol 284: H49-H55, 2003. (Pubitemid 36076269)
14. Napoli C, William-Ignarro S, Byrns R, Balestrieri ML, Crimi E, Farzati B, Mancini FP, de Nigris F, Matarazzo A, D'Amora M, Abbondanza C, Fiorito C, Giovane A, Florio A, Varricchio E, Palagiano A, Minucci PB, Tecce MF, Giordano A, Pavan A, Ignarro LJ. Therapeutic targeting of the stem cell niche in experimental hindlimb ischemia. Nat Clin Pract Cardiovasc Med 5: 571-579, 2008.
15. Nekolla SG, Miethaner C, Nguyen N, Ziegler SI, Schwaiger M. Reproducibility of polar map generation and assessment of defect severity and extent assessment in myocardial perfusion imaging using positron emission tomography. Eur J Nucl Med 25: 1313-1321, 1998. (Pubitemid 28446059)
16. Ohtsuka M, Takano H, Zou Y, Toko H, Akazawa H, Qin Y, Suzuki M, Hasegawa H, Nakaya H, Komuro I. Cytokine therapy prevents left ventricular remodeling and dysfunction after myocardial infarction through neovascularization. FASEB J 18: 851-853, 2004.
17. Orlic D, Hill JM, Arai AE. Stem cells for myocardial regeneration. Circ Res 91: 1092-1102, 2002.
18. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, Nadal-Ginard B, Bodine DM, Leri A, Anversa P. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci USA 98: 10344-10349, 2001. (Pubitemid 32803022)
19. Pitchford SC, Furze RC, Jones CP, Wengner AM, Rankin SM. Differential mobilization of subsets of progenitor cells from the bone marrow. Cell Stem Cell 4: 62-72, 2009.
20. Schluter KD, Piper HM. Cardiovascular actions of parathyroid hormone and parathyroid hormone-related peptide. Cardiovasc Res 37: 34-41, 1998. (Pubitemid 28122613)
21. Schluter KD, Schreckenberg R, Wenzel S. Stem cell mobilization versus stem cell homing: potential role for parathyroid hormone? Cardiovasc Res 77: 612-613, 2008. (Pubitemid 351301881)
22. Shimizu E, Selvamurugan N, Westendorf JJ, Partridge NC. Parathyroid hormone regulates histone deacetylases in osteoblasts. Ann NY Acad Sci 1116: 349-353, 2007. (Pubitemid 350274330)
23. Steinhauser ML, Lee RT. Cardiovascular regeneration: pushing and pulling on progenitors. Cell Stem Cell 4: 277-278, 2009.
24. Strauer BE, Brehm M, Zeus T, Kostering M, Hernandez A, Sorg RV, Kogler G, Wernet P. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 106: 1913-1918, 2002.
25. Wollenweber T, Zach C, Rischpler C, Fischer R, Nowak S, Nekolla SG, Grobner M, Ubleis C, Assmann G, La Fougere C, Boning G, Cumming P, Franz WM, Hacker M. Myocardial perfusion imaging is feasible for infarct size quantification in mice using a clinical single-photon emission computed tomography system equipped with pinhole collimators. Mol Imaging Biol In press.
26. Zaruba MM, Huber BC, Brunner S, Deindl E, David R, Fischer R, Assmann G, Herbach N, Grundmann S, Wanke R, Mueller-Hoecker J, Franz WM. Parathyroid hormone treatment after myocardial infarction promotes cardiac repair by enhanced neovascularization and cell survival. Cardiovasc Res 77: 722-731, 2008. (Pubitemid 351301860)
27. Zaruba MM, Theiss HD, Vallaster M, Mehl U, Brunner S, David R, Fischer R, Krieg L, Hirsch E, Huber B, Nathan P, Israel L, Imhof A, Herbach N, Assmann G, Wanke R, Mueller-Hoecker J, Steinbeck G, Franz WM. Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell 4: 313-323, 2009.
28. Zohlnhofer D, Ott I, Mehilli J, Schomig K, Michalk F, Ibrahim T, Meisetschlager G, von Wedel J, Bollwein H, Seyfarth M, Dirschinger J, Schmitt C, Schwaiger M, Kastrati A, Schomig A. Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial. J Am Med Assoc 295: 1003-1010, 2006. (Pubitemid 43313716)