Parathyroid hormone-related peptide improves contractile function of stunned myocardium in rats and pigs

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 284, Issue 1 53-1, 2003, Pages

  Jansen, Johanna ^a   Gres, Petra ^a   Umschlag, Christian ^a   Heinzel, Frank R ^a   Degenhardt, Heike ^b   Schlüter, Klaus Dieter ^b   Heusch, Gerd ^a   Schulz, Rainer ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Coronary blood flow; Hormones; Inotropy; Ischemia; Reperfusion

Indexed keywords

PARATHYROID HORMONE RELATED PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY VASCULAR RESISTANCE; ENZYME ACTIVITY; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; ISOLATED HEART; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; STUNNED HEART MUSCLE; SWINE;

EID: 0037235167     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.01037.2001     Document Type: Article

References (28)

1. Bloch W, Mehlhorn U, Krahwinkel A, Reinert M, Dittrich M, Schmidt A, and Addicks K. Ischemia increases detectable endothelial nitric oxide synthase in rat and human myocardium. Nitric Oxide 5: 317-333, 2001.
2. 1 adenosine receptors prevents the ischaemia-induced sensitisation of adenylyl cyclase: Evidence for a protein kinase C-mediated pathway. Basic Res Cardiol 94: 472-480, 1999.
3. Burton DW, Brandt DW, and Deftos LJ. Parathyroid hormone-related protein in the cardiovascular system. Endocrinology 135: 253-261, 1994.
4. Caldarone CA, Krukenkamp IB, Burns PG, Misare BD, Gaudette GR, and Levitsky S. Ischemia-dependent efficacy of phosphodiesterase inhibition. Ann Thorac Surg 57: 540-545, 1994.
5. Degenhardt H, Jansen J, Schulz R, Sedding D, Braun-Dullaeus R, and Schlüter KD. Mechanosensitive release of parathyroid hormone-related peptide from coronary endothelial cells. Am J Physiol Heart Circ Physiol 283: H1489-H1496, 2002.
6. Goldman ME, McKee RL, Caulfield MP, Reagan JF, Levy JJ, Gay CT, De Haven PA, Rosenblatt M, and Chorev M. A new highly potent parathyroid hormone antagonist. Endocrinology 123: 2597-2599, 1988.
7. f, and the slope of the pacemaker potential. Circulation 96: 3704-3709, 1997.
8. Heusch G, Rose J, Skyschally A, Post H, and Schulz R. Calcium responsiveness in regional myocardial short-term hibernation and stunning in the in situ porcine heart-inotropic responses to postextrasystolic potentiation and intracoronary calcium. Circulation 93: 1556-1566, 1996.
9. Juppner H, Schipani E, Bringhurst FR, Mc Clure I, Keutmann HT, Potts JT Jr Kronenberg HM, Abou-Samra AB, Segre GV, and Gardella TJ. The extracellular amino-terminal region of the parathyroid hormone (PTII)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTII-(1-34). Endocrinology 134: 879-884, 1994.
10. 2a agonist CGS-21680 in infarcted and stunned porcine myocardium. Am J Physiol Heart Circ Physiol 280: H1660-H1666, 2001.
11. Laugwitz KL, Weig HJ, Moretti A, Hoffmann E, Ueblacker P, Pragst I, Rosport K, Schömig A, and Ungerer M. Gene transfer of heterologous G protein-coupled receptors to cardiomyocytes: Differential effects on contractility. Circ Res 88: 688-695, 2000.
12. Massfelder T, Stewart AF, Endlich K, Soifer N, Judes C, and Helwig JJ. Parathyroid hormone-related protein detection and interaction with NO and cyclic AMP in the renovascular system. Kidney Int 50: 1591-1603, 1996.
13. Nickols GA, Nana AD, Nickols MA, DiPette DJ, and Asimakis GK. Hypotension and cardiac stimulation due to the parathyroid hormone-related protein, humoral hypercalcemia of malignancy factor. Endocrinology 125: 834-841, 1989.
14. Ogino K, Burkhoff D, and Bilezikian JP. The hemodynamic basis for the cardiac effects of parathyroid hormone (PTH) and PTH-related protein. Endocrinology 136: 3024-3030, 1995.
15. Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Braodus AE, and Stewart AF. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiol Rev 76: 127-173, 1996.
16. Ping P, Takano H, Zhang J, Tang XL, Qiu Y, Li RCX, Banerjee S, Dawn B, Balafonova Z, and Bolli R. Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits. Circ Res 84: 587-604, 1999.
17. Ping P, Zhang Y, Tang XL, Manchikalapudi S, Cao X, and Bolli R. Ischemic preconditioning induces selective translocation of protein kinase C isoforms ε and n in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity. Circ Res 81: 404-414, 1997.
18. Roca-Cusachs A, DiPette DJ, and Nickols GA. Regional and systemic hemodynamic effects of parathyroid hormone-related protein: Preservation of cardiac function and coronary and renal flow with reduced blood pressure. J Pharmacol Exp Ther 256: 110-118, 1991.
19. Schlüter KD, Katzer C, Frischkopf K, Wenzel S, Taimor G, and Piper HM. Expression, release, and biological activity of parathyroid hormone-related peptide from coronary endothelial cells. Circ Res 86: 946-951, 2000.
20. Schlüter KD and Piper HM. Cardiovascular actions of parathyroid hormone and parathyroid hormone-related peptide. Cardiovasc Res 37: 34-41, 1998.
21. Schlüter KD, Weber M, and Piper HM. Effects of PTHrP(107-111) and PTH-rP(7-34) on adult cardiomyocytes. J Mol Cell Cardiol 29: 3057-3065, 1997.
22. Schulz R, Guth BD, and Heusch G. No effect of coronary perfusion on regional myocardial function within the autoregulatory range in pigs: Evidence against the Gregg phenomenon. Circulation 83: 1390-1403, 1991.
23. Schulz R, Janssen F, Guth BD, and Heusch G. Effect of coronary hyperperfusion on regional myocardial function and oxygen consumption of stunned myocardium in pigs. Basic Res Cardiol 86: 534-543, 1991.
24. Simeoni U, Massfelder T, Saussine C, Judes C, Geisert J, and Helwig JJ. Involvement of nitric oxide in the vasodilatory response to parathyroid hormone-related peptide in the isolated rabbit kidney. Clin Sci (Lond) 86: 245-249, 1994.
25. Skyschally A, Schulz R, and Heusch G. Cordat II: a new program for data acquisition and on-line calculation of hemodynamic and regional myocardial dimension parameters. Comput Biol Med 23: 359-367, 1993.
26. Stahl LD, Aversano TR, and Becker LC. Selective enhancement of function of stunned myocardium by increased flow. Circulation 74: 843-851, 1986.
27. Stankovicova T, Szilard M, De Scheerder I, and Sipido KR. M cells and transmural heterogeneity of action potential configuration in myocytes from the left ventricular wall of the pig heart. Cardiovasc Res 45: 952-960, 2000.
28. Strasser RH, Braun-Dullaeus R, Walendzik H, and Marquetant R. α1-receptor-independent activation of protein kinase C in acute myocardial ischemia. Mechanisms for sensitization of the adenylate cyclase system. Circ Res 70: 1304-1312, 1992.