In vitro activity of tigecycline in Plasmodium falciparum culture-adapted strains and clinical isolates from Gabon

International Journal of Antimicrobial Agents

Volumn 35, Issue 6, 2010, Pages 587-589

  Held, Jana ^a   Zanger, Philipp ^a   Issifou, Saadou ^b   Kremsner, Peter G ^a,b   Mordmüller, Benjamin ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Hôpital Albert Schweitzer   (Gabon)

Author keywords

Glycylcyclines; Malaria; Plasmodium falciparum; Tetracyclines

Indexed keywords

CHLOROQUINE; CLINDAMYCIN; DOXYCYCLINE; MINOCYCLINE; TETRACYCLINE; TIGECYCLINE;

ADOLESCENT; ADULT; ANTIMALARIAL ACTIVITY; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; GABON; HUMAN; IC 50; IN VITRO STUDY; INFANT; MALARIA FALCIPARUM; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ADOLESCENT; ANIMALS; ANTIMALARIALS; CHILD; CHILD, PRESCHOOL; CLINDAMYCIN; GABON; HUMANS; INFANT; INHIBITORY CONCENTRATION 50; MALARIA, FALCIPARUM; MINOCYCLINE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; TETRACYCLINE; TIME FACTORS;

EID: 77951766720     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2010.02.003     Document Type: Article

References (15)

1. Mordmüller B., Kremsner P.G. Malarial parasites vs. antimalarials: never-ending rumble in the jungle. Curr Mol Med 2006, 6:247-251.
2. Rosenthal P.J. Antimalarial drug discovery: old and new approaches. J Exp Biol 2003, 206:3735-3744.
3. Lell B., Kremsner P.G. Clindamycin as an antimalarial drug: review of clinical trials. Antimicrob Agents Chemother 2002, 46:2315-2320.
4. Kremsner P.G., Radloff P., Metzger W., Wildling E., Mordmüller B., Philipps J., et al. Quinine plus clindamycin improves chemotherapy of severe malaria in children. Antimicrob Agents Chemother 1995, 39:1603-1605.
5. Goodman C.D., Su V., McFadden G.I. The effects of anti-bacterials on the malaria parasite Plasmodium falciparum. Mol Biochem Parasitol 2007, 152:181-191.
6. Dahl E.L., Rosenthal P.J. Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Antimicrob Agents Chemother 2007, 51:3485-3490.
7. Dahl E.L., Shock J.L., Shenai B.R., Gut J., DeRisi J.L., Rosenthal P.J. Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother 2006, 50:3124-3131.
8. Olson M.W., Ruzin A., Feyfant E., Rush T.S., O'Connell J., Bradford P.A. Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother 2006, 50:2156-2166.
9. 2+ cleavage of 16S rRNA. J Antimicrob Chemother 2004, 53:592-599.
10. Noedl H., Bronnert J., Yingyuen K., Attlmayr B., Kollaritsch H., Fukuda M. Simple histidine-rich protein 2 double-site sandwich enzyme-linked immunosorbent assay for use in malaria drug sensitivity testing. Antimicrob Agents Chemother 2005, 49:3575-3577.
11. Divo A.A., Geary T.G., Jensen J.B. Oxygen- and time-dependent effects of antibiotics and selected mitochondrial inhibitors on Plasmodium falciparum in culture. Antimicrob Agents Chemother 1985, 27:21-27.
12. Pradines B., Rogier C., Fusai T., Mosnier J., Daries W., Barret E., et al. In vitro activities of antibiotics against Plasmodium falciparum are inhibited by iron. Antimicrob Agents Chemother 2001, 45:1746-1750.
13. Pradines B., Spiegel A., Rogier C., Tall A., Mosnier J., Fusai T., et al. Antibiotics for prophylaxis of Plasmodium falciparum infections: in vitro activity of doxycycline against Senegalese isolates. Am J Trop Med Hyg 2000, 62:82-85.
14. Starzengruber P., Thriemer K., Haque R., Khan W.A., Fuehrer H.P., Siedl A., et al. Antimalarial activity of tigecycline, a novel glycylcycline antibiotic. Antimicrob Agents Chemother 2009, 53:4040-4042.
15. Agwuh K.N., MacGowan A. Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother 2006, 58:256-265.