A novel liquid-liquid extraction and stable isotope dilution NCI-GC-MS method for quantitation of agmatine in postmortem brain cortex

Journal of Mass Spectrometry

Volumn 45, Issue 5, 2010, Pages 560-565

  Chen, Gary Gang ^a   Turecki, Gustavo ^a   Mamer, Orval A ^b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Agmatine; Arginine; Depression; Gas chromatography; HFAA; Isopropanol; Negative ion chemical ionization mass spectrometry; Polyamines; Suicide

Indexed keywords

AGMATINE; BRAIN CORTEX; BRAIN TISSUE; DERIVATIZATION REAGENT; GC-MS ANALYSIS; INTERNAL STANDARDS; ISO-PROPANOLS; L-ARGININE; LIMIT OF DETECTION; LIQUID-LIQUID EXTRACTION; MENTAL DISORDERS; N-BUTANOL; NCI-GC-MS; NEGATIVE CHEMICAL IONIZATION; NEGATIVE ION CHEMICAL IONIZATION; POLYAMINES; POTASSIUM CARBONATES; QUANTITATION LIMITS; SALTING-OUT AGENTS; SELECTED ION MONITORING; SIMULTANEOUS MEASUREMENT; SPERMIDINE; STABLE ISOTOPE DILUTION; STABLE ISOTOPE DILUTION ASSAY; WET TISSUES;

AMINES; AMINO ACIDS; BRAIN; GAS CHROMATOGRAPHY; IONIZATION OF GASES; IONIZATION OF LIQUIDS; ISOTOPES; LIQUIDS; MASS SPECTROMETRY; NEGATIVE IONS; PARTICLE DETECTORS; SYNTHESIS (CHEMICAL);

SOLVENT EXTRACTION;

2 PROPANOL; ACETYLACETONE; AGMATINE; ARGININE; BUTANOL; HEXAFLUOROACETYLACETONE; ISOTOPE; POTASSIUM CARBONATE; STABLE ISOTOPE; UNCLASSIFIED DRUG;

ARTICLE; BRAIN CORTEX; BRAIN TISSUE; CONTROLLED STUDY; DERIVATIZATION; DILUTION; HUMAN; HUMAN TISSUE; ION MONITORING; ISOTOPE DILUTION ASSAY; LIQUID LIQUID EXTRACTION; MASS FRAGMENTOGRAPHY; PRIORITY JOURNAL; SYNTHESIS;

2-PROPANOL; AGMATINE; CALIBRATION; CEREBRAL CORTEX; CHEMICAL FRACTIONATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HYDROCARBONS, FLUORINATED; ISOTOPE LABELING; LINEAR MODELS; NITROGEN ISOTOPES; PENTANONES; SENSITIVITY AND SPECIFICITY;

EID: 77951748571     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1742     Document Type: Article

References (16)

1. L. M. Fiori,G. Turecki. Implication of the polyamine system inmental disorders. J. Psychiatry Neurosci. 2008, 33, 102.
2. M.Guipponi, S. Deutsch, K. Kohler, N. Perroud, F. Le Gal, M. Vessaz, T. Laforge, B. Petit, F. Jollant, S. Guillaume, P. Baud, P. Courtet, R. La Harpe, A. Malafosse. Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009, 150B, 799.
3. A. M. Karssen, S. Her, J. Z. Lici, P. D. Patel, F. Meng, W. E. Bunney Jr., E. G. Jones, S. J. Watson, H. Akil, R. M. Myers, A. F. Schatzberg, D. M. Lyons. Stress-induced changes in primate prefrontal profiles of gene expression. Mol. Psychiatry 2007, 12, 1089.
4. A. Sequeira,F. G.Gwadry, J.M. Ffrench-Mullen,L.Canetti, Y. Gingras, R. A. Casero Jr., G. Rouleau, C. Benkelfat, G. Turecki. Implication of SSAT by gene expression and genetic variation in suicide andmajor depression. Arch. Gen. Psychiatry 2006, 63, 35.
5. K. Kashiwagi,A. J. Pahk, T. Masuko, K. Igarashi, K. Williams. Block and modulation of N-methyl-D-aspartate receptors by polyamines and protons: role of amino acid residues in the transmembrane and pore-forming regions of NR1 and NR2 subunits. Mol. Pharmacol. 1997, 52, 701.
6. R. T. Layer, P. Popik, T.Olds, P. Skolnick. Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715). Pharmacol. Biochem. Behav. 1995, 52, 621.
7. A. D. Zomkowski, A. R. Santos, A. L. Rodrigues. Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 2006, 30, 1419.
8. L. P. Kozaeva, N. V. Korobov. Agmatine - an endogenous ligand of imidazoline receptors [in Russian]. Eksp. Klin. Farmakol. 2003, 66, 69.
9. D. J. Reis, S. Regunathan. Is agmatine a novel neurotransmitter in brain? Trends Pharmacol. Sci. 2000, 21, 187.
10. J. Satriano, C. J. Kelly, R. C. Blantz. An emerging role for agmatine. Kidney Int. 1999, 56, 1252.
11. G. G. Chen, G. Turecki, O. A. Mamer. A quantative GC-MS method for three major polyamines in post-mortem brain cortex. J Mass Spectrom. 2009, 44, 1203.
12. B. Dorhout, H. Ferwerda, A. W. Kingma, E. de Hoog, F. A. Muskiet. In vivo manipulation of L1210 cell cycle phase distribution with alpha- difluoromethylornithine, 4-amidinoindan-1-one 2′-amidinohydrazone and N1-acetylspermine. Acta Biochim. Biophys. 1998, 1381, 89.
13. F. A. Muskiet, B. Dorhout, G. A. van den Berg, J. Hessels. Investigation of polyamine metabolism by high-performance liquid chromatographic and gas chromatographic profiling methods. J. Chromatogr. B Biomed. Appl. 1995, 667, 189.
14. F. A. Muskiet, G. A. van den Berg, A. W. Kingma, D. C. Fremouw-Ottevangers, M. R. Halie. Total polyamines and their non-alpha-amino acid metabolites simultaneously determined in urine by capillary gas chromatography, with nitrogen-phosphorus detector; and some clinical applications. Clin. Chem. 1984, 30, 687.
15. O. Horyn, B. Luhovyy, A. Lazarow, Y. Daikhin, I. Nissim, M. Yudkoff, I. Nissim. Biosynthesis of agmatine in isolated mitochondria and perfused rat liver: studies with 15N-labelled arginine. Biochem. J. 2005, 388, 419.
16. D. Stickle, A. Bohrer, R. Berger, J. Morrissey, S. Klahr, J. Turk. Quantitation of the putative neurotransmitter agmatine as the hexafluoroacetylacetonate derivative by stable isotope dilution gas chromatography and negative-ion chemical ionization mass spectrometry. Anal. Biochem. 1996, 238, 129.