Serum antibodies in epilepsy and seizure-associated disorders

Neurology

Volumn 65, Issue 11, 2005, Pages 1730-1736

  McKnight, K ^a   Jiang, Y ^a   Hart, Y ^b   Cavey, A ^b   Wroe, S ^c   Blank, M ^d,e   Shoenfeld, Y ^d,e   Vincent, A ^a   Palace, J ^b   Lang, B ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b RADCLIFFE INFIRMARY   (United Kingdom)

^c NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^d SHEBA MEDICAL CENTER   (Israel)

^e TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; AUTOANTIBODY; BRAIN ANTIGEN; CARDIOLIPIN; CELL NUCLEUS ANTIGEN; CORTICOSTEROID; DNA; GANGLIOSIDE; GLUTAMATE DECARBOXYLASE; GLUTAMATE RECEPTOR 3; IMMUNOGLOBULIN; ION CHANNEL; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL; 4 AMINOBUTYRIC ACID; ANTIGEN; IMMUNOLOGIC FACTOR; NERVE PROTEIN;

ACUTE DISEASE; ADOLESCENT; ADULT; ANTIBODY BLOOD LEVEL; ANTIBODY TITER; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CONTROLLED STUDY; DISEASE DURATION; EPILEPSY; FEMALE; HUMAN; IMMUNE SYSTEM; IMMUNOMODULATION; IMMUNOTHERAPY; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PLASMAPHERESIS; PRIORITY JOURNAL; SEIZURE; TREATMENT RESPONSE; BIOSYNTHESIS; BLOOD; BRAIN; IMMUNOLOGY; NERVE CELL INHIBITION; PATHOPHYSIOLOGY; PREDICTION AND FORECASTING;

ADOLESCENT; ADULT; ANTIGENS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; BRAIN; EPILEPSY; FEMALE; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; HUMANS; IMMUNOLOGIC FACTORS; MALE; NERVE TISSUE PROTEINS; NEURAL INHIBITION; POTASSIUM CHANNELS, VOLTAGE-GATED; PREDICTIVE VALUE OF TESTS;

EID: 33645053556     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.wnl.0000187129.66353.13     Document Type: Article

References (31)

1. Meisler MH, Kearney J, Ottman R, Escayg A. Identification of epilepsy genes in human and mouse. Ann Rev Genet 2001;35:567-588.
2. Macdonald RL, Kelly KM. Mechanisms of action of currently prescribed and newly developed antiepileptic drugs. Epilepsia 1994;35:S41-S50.
3. Palace J, Lang B. Epilepsy: an autoimmune disease? J Neurol Neurosurg Psychiatry 2000;69:711-714.
4. Van Engelen BGM, Renier WO, Weemaes CMR, Gabreels FJM, Meinardi H. Immunoglobulin treatment in epilepsy: a review of the literature. Epilepsy Res 1994;19:181-190.
5. Bartolomei F, Boucraut J, Barrie M, et al. Cryptogenic partial epilepsies with anti-GM1 antibodies: a new form of immune-mediated epilepsy? Epilepsia 1996;37:922-926.
6. Rogers SW, Andrews PI, Gahring LC, et al. Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis. Science 1994;265:648-651.
7. Mantegazza R, Bernasconi P, Baggi F, et al. Antibodies against GluR3 peptides are not specific for Rasmussen's encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures. J Neuroimmunol 2002;131:179-185.
8. Dambinova SA, Izykenova GA, Burov SV, Grigorenko EV, Gromov SA. The presence of autoantibodies to N-terminus domain of GluR1 subunit of AMPA receptor in the blood serum of patients with epilepsy. J Neurol Sci 1997;152:93-97.
9. Peltola J, Kulmala P, Isojarvi J, et al. Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy. Neurol 2000;55:46-50.
10. Shoenfeld Y, Lev S, Blatt I, et al. Features associated with epilepsy in the antiphospholipid syndrome. J Rheumatol 2004;31:1344-1348.
11. Vincent A, Buckley C, Schott J, et al. Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain 2004;127:701-712.
12. + channels are implicated in neuromyotonia. Ann Neurol 1997;41:238-246.
13. Motomura M, Lang B, Johnston I, Palace J, Vincent A, Newsom-Davis J. Incidence of serum anti-P/Q-type and anti-N-type calcium channel autoantibodies in the Lambert-Eaton myasthenic syndrome. J Neurol Sci 1997;47:35-42.
14. Watson RJ, Jiang Y, Bermudez I, et al. Absence of antibodies to glutamate receptor type 3 (GluR3) in Rasmussen's encephalitis. Neurology 2004;63:43-50.
15. Shoenfeld Y, Rauch J, Massicotte H, et al. Polyspecificity of monoclonal lupus autoantibodies produced by human-human hybridomas. N Engl J Med 1983;308:414-420.
16. Blank M, Kraus I, Fridkin M, et al. Bacterial induction of autoantibodies to β2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome. J Clin Invest 2002;109:797-804.
17. Solimena M, Folli F, Denis-Domini S, et al. Autoantibodies to glutamic acid decarboxylase in a patient with stiff man syndrome, epilepsy and type I diabetes mellitus. N Engl J Med 1988;318:1012-1020.
18. Abele M, Weller M, Mescheriakov S, Burk K, Dichgans J, Klockgether T. Cerebellar ataxia with glutamic acid decarboxylase autoantibodies. Neurology 1999;2:857-859.
19. Bonifacio E, Genovese S, Braghi S, et al. Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity. Diabetologia 1995;38:816-822.
20. Seissler J, Amann J, Mauch L, et al. Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin dependent diabetes mellitus. J Clin Invest 1993;92:1394-1399.
21. Zuberi SM, Eunson LH, Spauschus A, et al. A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy. Brain 1999;22:817-825.
22. Buckley C, Oger J, Clover L, et al. Potassium channel antibodies in two patients with reversible limbic encephalitis. Ann Neurol 2001;50:73-78.
23. Thieben MJ, Lennon VA, Boeve BF, Aksamit AJ, Keegan M, Vernino S. Potentially reversible autoimmune limbic encephalitis with neuronal potassium channel antibody. Neurology 2004;62:1177-1182.
24. Chong JY, Rowland LP, Utiger RD. Hashimoto's encephalopathy: syndrome or myth? Arch Neurol 2003;60:164-171.
25. Kwan P, Sills GJ, Kelly K, Butler E, Brodie MJ. Glutamic acid decarboxylase autoantibodies in controlled and uncontrolled epilepsy: a pilot study. Epilepsy Res 2000;42:191-195.
26. Vianello M, Vitaliani R, Pezzani R, et al. The spectrum of antineuronal autoantibodies in a series of neurological patients. J Neurol Sci 2004;220:29-36.
27. Heckenlively JR, Fawzi AA, Oversier J, Jordan BL, Aptsiauri N. Autoimmune retinopathy: patients with antirecoverin immunoreactivity and panretinal degeneration. Arch Ophthalmol 2000;118:1525-1533.
28. Mitoma H, Song S-Y, Ishida K, Yamakuni T, Kobayashi T, Mizusawa H. Presynaptic impairment of cerebellar inhibitory synapses by an autoantibody to glutamate decarboxylase. J Neurol Sci 2000;175:40-44.
29. Peltola JT, Haapala A, Isojarvi JI, et al. Antiphospholipid and antinuclear antibodies in patients with epilepsy or new-onset seizure disorders. Am J Med 2000;109:712-717.
30. Ruffatti A, Calligaro A, DelRoss T, et al. Anti-double-stranded DNA antibodies in the healthy elderly: prevalence and characteristics. J Clin Immunol 1990;10:300-303.
31. Wiendl H, Bien CG, Bernasconi P, et al. GluR3 antibodies: prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis. Neurology 2001;57:1511-1514.