DOG1 for the diagnosis of gastrointestinal stromal tumor (GIST): Comparison between 2 different antibodies

Applied Immunohistochemistry and Molecular Morphology

Volumn 18, Issue 4, 2010, Pages 333-337

  Lopes, Lisandro F ^a   West, Robert B ^b   Bacchi, Livia M ^c   Van De Rijn, Matt ^b   Bacchi, Carlos E ^a  

^a Consultoria em Patologia ^*  (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DOG1; gastrointestinal stromal tumor; GIST; immunohistochemistry; KIT

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY DOG1.1; MONOCLONAL ANTIBODY K9; PROTEIN DOG1; STEM CELL FACTOR RECEPTOR; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ADENOID CYSTIC CARCINOMA; ANGIOSARCOMA; ARTICLE; BREAST FIBROADENOMA; CONTROLLED STUDY; GASTROINTESTINAL STROMAL TUMOR; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEIOMYOSARCOMA; MAJOR CLINICAL STUDY; MYOEPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNOVIAL SARCOMA;

ANTIBODIES, MONOCLONAL; GASTROINTESTINAL STROMAL TUMORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MICROARRAY ANALYSIS; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS C-KIT; SARCOMA;

EID: 77951703661     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0b013e3181d27ec8     Document Type: Article

References (19)

1. Rubin BP. Gastrointestinal stromal tumours: an update. Histo-pathology. 2006;48:83-96.
2. Miettinen M, Lasota J. Gastrointestinal stromal tumours. Review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med. 2006;130:1466-1478.
3. Hornick JL, Fletcher CD. The role of KIT in the management of patients with gastrointestinal stromal tumors. Hum Pathol. 2007;38: 679-687.
4. Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998;279: 577-580. (Pubitemid 28067289)
5. Corless CL, McGreevey L, Haley A, et al. KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size. Am J Pathol. 2002;160:1567-1572.
6. Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science. 2003;299: 708-710.
7. Demetri GD, Von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002;347:472-480.
8. Demetri GD, Van Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomized controlled trial. Lancet. 2006;368:1329-1338.
9. Medeiros F, Corless CL, Duensing A, et al. KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications. Am J Surg Pathol. 2004;28:889-894.
10. Lopes LF, Ojopi EB, Bacchi CE. Gastrointestinal stromal tumor in Brazil: clinicopathology, immunohistochemistry, and molecular genetics of 513 cases. Pathol Int. 2008;58:344-352.
11. West RB, Corless CL, Chen X, et al. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol. 2004;165:107-113.
12. Espinosa I, Lee CH, Kim MK, et al. A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. Am J Surg Pathol. 2008;32:210-218.
13. Liegl B, Hornick JL, Corless CL, et al. Monoclonal antibody DOG1.1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes. Am J Surg Pathol. 2009;33:437-446.
14. Miettinen M, Wang ZF, Lasota J. DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. Am J Surg Pathol. 2009;33:1401-1408.
15. Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol. 2002;33: 459-465. (Pubitemid 34747864)
16. Blay JY. New paradigms in gastrointestinal stromal tumour management. Ann Oncol. 2009;20:i18-i24.
17. Katoh M, Katoh M. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. Int J Oncol. 2003;22:1375-1381.
18. Caputo A, Caci E, Ferrera L, et al. TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science. 2008;322:590-594.
19. Yang YD, Cho H, Koo JY, et al. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature. 2008; 455:1210-1215.