Anandamide induces cell death through lipid rafts in hepatic stellate cells

Journal of Gastroenterology and Hepatology (Australia)

Volumn 25, Issue 5, 2010, Pages 991-1001

  Yang, Qiao ^a   Liu, Hong Yan ^a   Zhang, Yao Wen ^a   Wu, Wen Jie ^a   Tang, Wang Xian ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Anandamide; Hepatic stellate cells; Lipid rafts

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 6; LIPOCORTIN 5; MESSENGER RNA; METHYL BETA CYCLODEXTRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; AMIDE; ARACHIDONIC ACID DERIVATIVE; AUTACOID; CHOLESTEROL; CNR2 PROTEIN, RAT; ENDOCANNABINOID;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL GROWTH; CELL NUCLEUS; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GROWTH INHIBITION; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; LIPID RAFT; LIVER CELL; MOLECULAR DYNAMICS; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; STELLATE CELL; WESTERN BLOTTING; FIBROGENESIS; LIVER FIBROSIS; ANIMAL; CELL LINE; CELL MEMBRANE; CELL PROLIFERATION; DEFICIENCY; DOSE RESPONSE; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; NECROSIS; NUCLEAR SHAPE; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ARACHIDONIC ACIDS; BLOTTING, WESTERN; CELL LINE; CELL NUCLEUS SHAPE; CELL PROLIFERATION; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCANNABINOIDS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HEPATIC STELLATE CELLS; INFLAMMATION MEDIATORS; INTERLEUKIN-2; INTERLEUKIN-6; MEMBRANE MICRODOMAINS; MICROSCOPY, CONFOCAL; NECROSIS; PHOSPHATIDYLINOSITOL 3-KINASES; POLYUNSATURATED ALKAMIDES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77951703628     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2009.06122.x     Document Type: Article

References (39)

1. Prosser CC, Yen RD, Wu J. Molecular therapy for hepatic injury and fibrosis: where are we? World. J. Gastroenterol. 2006 12 : 509 515. (Pubitemid 43380778)
2. Watson SJ, Benson JA Jr., Joy JE. Marijuana and medicine: assessing the science base: a summary of the 1999 Institute of Medicine report. Arch. Gen. Psychiatry 2000 57 : 547 552.
3. Singh J, Budhiraja S. Therapeutic potential of cannabinoid receptor ligands: current status. Methods Find. Exp. Clin. Pharmacol. 2006 28 : 177 183. (Pubitemid 43938541)
4. Walker JM, Hohmann AG, Martin WJ, Strangman NM, Huang SM, Tsou K. The neurobiology of cannabinoid analgesia. Life Sci. 1999 65 : 665 673. (Pubitemid 29362772)
5. Martínez-Rodríguez JE, Munteis E, Carreño M et al. Cannabis use in Spanish patients with multiple sclerosis: fulfilment of patients' expectations? J. Neurol. Sci. 2008 273 : 103 107.
6. Molina-Holgado F, Molina-Holgado E, Guaza C. The endogenous cannabinoid anandamide potentiates interleukin-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor-mediated pathway. FEBS Lett. 1998 433 : 139 142. (Pubitemid 28386745)
7. Pisanti S, Borselli C, Oliviero O, Laezza C, Gazzerro P, Bifulco M. Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor-suppressor efficacy. J. Cell. Physiol. 2007 211 : 495 503. (Pubitemid 46580103)
8. Domenicali M, Ros J, Fernández-Varo G et al. Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: role of cannabinoid and vanilloid receptors. Gut 2005 54 : 522 527. (Pubitemid 40395505)
9. Siegmund SV, Uchinami H, Osawa Y, Brenner DA, Schwabe RF. Anandamide induces necrosis in primary hepatic stellate cells. Hepatology 2005 41 : 1085 1095. (Pubitemid 40593916)
10. Guzmán M, Sánchez C, Galve-Roperh I. Cannabinoids and cell fate. Pharmacol. Ther. 2002 95 : 175 184. (Pubitemid 35232135)
11. Velasco L, Ruiz L, Sánchez MG, Díaz-Laviada I. delta(9)-Tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells. Involvement of CB1 cannabinoid receptor and Raf-1. Eur. J. Biochem. 2001 268 : 531 535. (Pubitemid 32862610)
12. Nakajima Y, Furuichi Y, Biswas KK et al. Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition. FEBS Lett. 2006 580 : 613 619. (Pubitemid 43089695)
13. Domenicali M, Ros J, Fernández-Varo G et al. Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: role of cannabinoid and vanilloid receptors. Gut 2005 54 : 522 527. (Pubitemid 40395505)
14. Sancho R, Calzado MA, Di Marzo V, Appendino G, Muñoz E. Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway. Mol. Pharmacol. 2003 63 : 429 438. (Pubitemid 36158379)
15. Ros J, Clària J, To-Figueras J et al. Endogenous cannabinoids: a new system involved in the homeostasis of arterial pressure in experimental cirrhosis in the rat. Gastroenterology 2002 122 : 85 93. (Pubitemid 34049198)
16. Elder DJ, Halton DE, Crew TE, Paraskeva C. Apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug NS-398. Int. J. Cancer 2000 86 : 553 560. (Pubitemid 30249738)
17. Jin S, Yi F, Li PL. Contribution of lysosomal vesicles to the formation of lipid raft redox signaling platforms in endothelial cells. Antioxid. Redox. Signal. 2007 9 : 1417 1426. (Pubitemid 47255022)
18. Gregory CD, Dive C, Henderson S et al. Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis. Nature 1991 349 (6310 612 614. (Pubitemid 21912115)
19. De Petrocellis L, Melck D, Palmisano A et al. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proc. Natl Acad. Sci. USA 1998 95 : 8375 8380. (Pubitemid 28326120)
20. Contassot E, Tenan M, Schnüriger V, Pelte MF, Dietrich PY. Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1. Gynecol. Oncol. 2004 93 : 182 188. (Pubitemid 38429568)
21. Pietrangelo A, Montosi G, Garuti C et al. Iron-induced oxidant stress in nonparenchymal liver cells: mitochondrial derangement and fibrosis in acutely iron-dosed gerbils and its prevention by silybin. J. Bioenerg. Biomembr. 2002 34 : 67 79. (Pubitemid 34157707)
22. Anan A, Baskin-Bey ES, Bronk SF, Werneburg NW, Shah VH, Gores GJ. Proteasome inhibition induces hepatic stellate cell apoptosis. Hepatology 2006 43 : 335 344. (Pubitemid 43304001)
23. Wright MC, Issa R, Smart DE et al. Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats. Gastroenterology 2001 121 : 685 698. (Pubitemid 32822584)
24. Derocq JM, Bouaboula M, Marchand J, Rinaldi-Carmona M, Ségui M, Casellas P. The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines. FEBS Lett. 1998 425 : 419 425. (Pubitemid 28178844)
25. Berdyshev EV, Schmid PC, Krebsbach RJ et al. Cannabinoid-receptor- independent cell signalling by N-acylethanolamines. Biochem. J. 2001 360 (Pt 1 67 75.
26. Sarker KP, Maruyama I. Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts. Cell. Mol. Life Sci. 2003 60 : 1200 1208. (Pubitemid 36791921)
27. Biswas KK, Sarker KP, Abeyama K et al. Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis. Hepatology 2003 38 : 1167 1177. (Pubitemid 37314825)
28. Simons K, Toomre D. Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 2000 1 : 31 9.
29. Movsesyan VA, Stoica BA, Yakovlev AG et al. Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways. Cell Death Differ. 2004 11 : 1121 1132.
30. Mimeault M, Pommery N, Wattez N, Bailly C, Hénichart JP. Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production. Prostate 2003 56 : 1 12. (Pubitemid 36613150)
31. Patsos HA, Hicks DJ, Dobson RR et al. The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2. Gut 2005 54 : 1741 1750.
32. Garcia-Echeverria C, Sellers WR. Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene 2008 27 : 5511 5526.
33. Ogasawara J, Watanabe-Fukunaga R, Adachi M et al. Lethal effect of the anti-Fas antibody in mice. Nature 1993 364 (6440 806 809. (Pubitemid 23261761)
34. Matsumura H, Shimizu Y, Ohsawa Y, Kawahara A, Uchiyama Y, Nagata S. Necrotic death pathway in Fas receptor signaling. J. Cell. Biol. 2000 151 : 1247 1256.
35. Baldwin GC, Tashkin DP, Buckley DM, Park AN, Dubinett SM, Roth MD. Marijuana and cocaine impair alveolar macrophage function and cytokine production. Am. J. Respir. Crit. Care Med. 1997 156 : 1606 1613.
36. Klein TW, Newton C, Widen R, Friedman H. Delta 9-tetrahydrocannabinol injection induces cytokine-mediated mortality of mice infected with Legionella pneumophila. J. Pharmacol. Exp. Ther. 1993 267 : 635 640. (Pubitemid 2017644)
37. Ban L, Zhang J, Wang L, Kuhtreiber W, Burger D, Faustman DL. Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism. Proc. Natl Acad. Sci. USA 2008 105 : 13644 13649.
38. Hara M, Nakanishi H, Tsujimura K et al. Interleukin-2 potentiation of cetuximab antitumor activity for epidermal growth factor receptor-overexpressing gastric cancer xenografts through antibody-dependent cellular cytotoxicity. Cancer Sci. 2008 99 : 1471 1478. (Pubitemid 351761740)
39. Jin X, Zhang Z, Beer-Stolz D, Zimmers TA, Koniaris LG. Interleukin-6 inhibits oxidative injury and necrosis after extreme liver resection. Hepatology 2007 46 : 802 812. (Pubitemid 47436127)