Function of phenylalanine 259 and threonine 314 within the substrate binding pocket of the juvenile hormone esterase of manduca sexta

Biochemistry

Volumn 49, Issue 17, 2010, Pages 3733-3742

  Kamita, Shizuo G ^a   Wogulis, Mark D ^b   Law, Christopher S ^a   Morisseau, Christophe ^a   Tanaka, Hiromasa ^a   Huang, Huazhang ^a   Wilson, David K ^b   Hammock, Bruce D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID METABOLITES; AMINO ACID RESIDUES; APPROPRIATE DISTANCES; CATALYTIC CYCLES; CHEMICAL BOND STRENGTH; HIGH SPECIFICITY; JUVENILE HORMONE; KINETIC ANALYSIS; MANDUCA SEXTA; METHYL ESTERS; NANOMOLAR LEVELS; NON-CATALYTIC; NUCLEOPHILIC ATTACK; RATE DETERMINING STEP; SUBSTRATE BINDING; UNSATURATED ESTERS; WATER MOLECULE;

AMINO ACIDS; BIOCHEMISTRY; BOND STRENGTH (CHEMICAL); COST REDUCTION; CRYSTAL STRUCTURE; ESTERIFICATION; ESTERS; HORMONES; HYDROLYSIS; METABOLISM; ORGANIC ACIDS; PHOSPHATASES;

SUBSTRATES;

EPOXIDE; ESTERASE; JUVENILE HORMONE; JUVENILE HORMONE ESTERASE; NUCLEOPHILE; PHENYLALANINE; THREONINE; UNCLASSIFIED DRUG; WATER;

ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CATALYSIS; CHEMICAL BOND; CRYSTAL STRUCTURE; ENZYME ASSAY; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; MANDUCA SEXTA; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; TURNOVER TIME; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; CARBOXYLIC ESTER HYDROLASES; CHROMATOGRAPHY, THIN LAYER; HYDROLYSIS; KINETICS; LARVA; MANDUCA; MODELS, MOLECULAR; MUTATION; PHENYLALANINE; SESQUITERPENES; SUBSTRATE SPECIFICITY; THREONINE;

HEXAPODA; MANDUCA SEXTA;

EID: 77951694694     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi901641x     Document Type: Article

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