Biochemical and structural characterization of mycobacterium tuberculosis β-lactamase with the carbapenems ertapenem and doripenem

Biochemistry

Volumn 49, Issue 17, 2010, Pages 3766-3773

  Tremblay, Lee W ^a   Fan, Fan ^a   Blanchard, John S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL-ENZYME COMPLEX; ANTIBACTERIALS; CARBAPENEMS; CONCENTRATION OF; COVALENT COMPLEX; DIFFRACTION DATA; FT-ICR MASS SPECTROMETRY; IN-VITRO; INTRINSIC RESISTANCE; LACTAMASES; MYCOBACTERIUM TUBERCULOSIS; POTENT INHIBITOR; SLOW SUBSTRATE; STEADY-STATE KINETICS; STRUCTURAL CHARACTERIZATION; TIME PERIODS; WATER MOLECULE;

ALKALINITY; AMIDES; ELECTRON TRANSITIONS; HYDROGEN BONDS; HYDROLYSIS; ISOMERIZATION; ISOMERS; MASS SPECTROMETRY; TERBIUM ALLOYS;

ENZYMES;

BETA LACTAMASE; CARBAPENEM; DORIPENEM; ERTAPENEM; HYDROGEN;

ARTICLE; CATALYSIS; CRYSTALLIZATION; DEACYLATION; ENZYME STABILITY; HYDROGEN BOND; HYDROLYSIS; IN VITRO STUDY; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; ISOMERIZATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; X RAY CRYSTALLOGRAPHY;

BETA-LACTAMASES; BETA-LACTAMS; CARBAPENEMS; CEPHALOSPORINS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CYCLOTRONS; FOURIER ANALYSIS; HYDROGEN BONDING; INDICATORS AND REAGENTS; KINETICS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION;

MYCOBACTERIUM TUBERCULOSIS;

EID: 77951676093     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100232q     Document Type: Article

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